Protein Data Bank goes global

November 21, 2003

NEW BRUNSWICK/PISCATAWAY, N.J. -- The Protein Data Bank (PDB), an international resource for biomedical research with facilities at Rutgers, The State University of New Jersey, became the focus of an international collaborative agreement today. The agreement establishes the Worldwide Protein Data Bank (wwPDB) and, in doing so, ensures a single, uniform and enduring archive of 3-dimensional models of biological structures, proteins specifically. An announcement of the agreement appears in the December issue of Nature Structural Biology.

"The PDB is an important tool for biomedical and pharmaceutical researchers and a critical asset to 21st century genomic research and drug design," said Rutgers Board of Governors Professor of Chemistry and Chemical Biology Helen M. Berman, director of the Protein Data Bank. "The agreement ensures and simplifies access to this important source of information for researchers worldwide."

The archived structures represent an increasingly large fraction of all the molecules of life - ones that will interact with new drugs being designed. These large molecular structures are determined by the most modern experimental methods, including X-ray crystallography, NMR spectroscopy and cryoelectron microscopy.

The Research Collaboratory for Structural Bioinformatics (RCSB), of which Rutgers is a member; the Macromolecular Structure Database at the European Bioinformatics Institute (MSD-EBI); and the Protein Data Bank Japan (PDBj) are signatories to the new agreement. They will be equal partners in managing the data bank, and each will maintain sites through which new protein data may be deposited and processed. The processed data will be forwarded to the RCSB and entered into a data bank archive by the RCSB - the "archive keeper" with sole direct access to the database and control over its directory structure and contents.

Prior to the agreement, RCSB members - Rutgers, the San Diego Supercomputer Center at the University of California, San Diego and the Center for Advanced Research in Biotechnology of the National Institute of Standards and Technology - managed the PDB. The data bank contains more than 23,000 structures, a number that has been growing exponentially. The PDB is supported by funds from the National Science Foundation, the Department of Energy and the National Institutes of Health.
-end-


Rutgers University

Related Biomedical Research Articles from Brightsurf:

General data protection regulation hinders global biomedical research
The European Union (EU) General Data Protection Regulation (GDPR) was designed to give EU citizens greater protection and control of their personal data, particularly when transferred to entities outside the EU.

Novel educational program puts a human face on biomedical research
The goal of translational research is to speed research breakthroughs into clinical practice.

Biomedical research may miss key information by ignoring genetic ancestry
A new study of Black residents of four distinct US cities reveals variations in genetic ancestry and social status that underscore the inadequacy of using skin color as a proxy for race in research.

Advances in cryo-EM materials may aid cancer and biomedical research
Cryogenic-Electron Microscopy (cryo-EM) has been a game changer in the field of medical research, but the substrate, used to freeze and view samples under a microscope, has not advanced much in decades.

World-first program uncovers errors in biomedical research results
Just like the wrong ingredients can spoil a cake, so too can the wrong ingredients spoil the results in biomedical research.

Scientists poised to study reproducibility of Brazilian biomedical research
A project to assess the reproducibility of biomedical research in Brazil has been described today in the open-access journal eLife.

Transparency and reproducibility of biomedical research is improving
New research publishing Nov. 20 in the open-access journal PLOS Biology from Joshua Wallach, Kevin Boyack, and John Ioannidis suggests that progress has been made in key areas of research transparency and reproducibility.

As private funding of biomedical research soars, new risks arise
Academic medical centers (AMCs) in the US are navigating an increasing shift in research funding from historic public funding (e.g., NIH) to private sources such as pharma and biotech companies, foundations, and charities, raising a host of new issues related to collaborative research models, intellectual property rights, and scientific and ethical oversight.

BGRF scientists co-publish research paper on blockchain & AI for biomedical applications
Biogerontology Research Foundation Chief Science Officer (CSO) co-authored the landmark paper in the journal Oncotarget on the convergence of blockchain and AI to decentralize and galvanize healthcare and biomedical research.

Promising new drug for Hep B tested at Texas Biomedical Research Institute
Research at the Southwest National Primate Research Center (SNPRC) on the campus of Texas Biomedical Research Institute helped advance a new treatment now in human trials for chronic hepatitis B virus (HBV) infection.

Read More: Biomedical Research News and Biomedical Research Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.