Breast milk sugar promotes colitis in offspring

November 22, 2010

A sugar found in mouse breast milk promotes the generation of colitis in offspring, according to a study published online on November 22 in the Journal of Experimental Medicine (www.jem.org).

Sugars in breast milk are essential for the development of the newborn immune system and the growth of beneficial commensal bacteria in the gut. But certain milk sugars in certain contexts could be bad news. A group led by Thierry Hennet at the University of Zurich found that newborn mice fostered by mothers lacking one particular milk sugar--sialyl(alpha2,3)lactose--were less susceptible to inflammation-induced colitis later in life. The resistance to colitis was attributed to differences in the commensal bacteria.

Determining whether this milk sugar has some redeeming qualities--for example in facilitating defense against dangerous intestinal pathogens--will require further studies.
-end-
About The Journal of Experimental Medicine

The Journal of Experimental Medicine (JEM) is published by The Rockefeller University Press. All editorial decisions on manuscripts submitted are made by active scientists in conjunction with our in-house scientific editors. JEM content is posted to PubMed Central, where it is available to the public for free six months after publication. Authors retain copyright of their published works and third parties may reuse the content for non-commercial purposes under a creative commons license. For more information, please visit www.jem.org.

Fuhrer, A., et al. 2010. J. Exp. Med. doi:10.1084/jem.20101098.

Rockefeller University Press

Related Breast Milk Articles from Brightsurf:

The "gold" in breast milk
Breast milk strengthens a child's immune system, supporting the intestinal flora.

Is COVID-19 transmitted through breast milk? Study suggests not likely
A recent study by researchers at University of California San Diego School of Medicine suggests transmission of COVID-19 through breast milk is not likely.

Mom and baby share 'good bacteria' through breast milk
A new study by researchers at the University of British Columbia and the University of Manitoba has found that bacteria are shared and possibly transferred from a mother's milk to her infant's gut, and that breastfeeding directly at the breast best supports this process.

Pasteurizing breast milk inactivates SARS-CoV-2
Pasteurizing breast milk using a common technique inactivates severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) making it safe for use, according to new research in CMAJ (Canadian Medical Association Journal). ttps://www.cmaj.ca/content/cmaj/early/2020/07/09/cmaj.201309.full.pdf

Breast milk may help prevent sepsis in preemies
Researchers at Washington University School of Medicine in St. Louis and Mayo Clinic in Rochester, Minn., have found -- in newborn mice -- that a component of breast milk may help protect premature babies from developing life-threatening sepsis.

New study associates intake of dairy milk with greater risk of breast cancer
Intake of dairy milk is associated with a greater risk of breast cancer in women -- up to 80% depending on the amount consumed -- according to a new study conducted by researchers at Loma Linda University Health.

Study: Difference in breast milk concentrations impacts growth up to age 5
In a new study, researchers at University of California San Diego School of Medicine confirmed the findings of previous pilot studies that found an association between human milk concentrations and infant weight and body composition.

Component of human breast milk enhances cognitive development in babies
CHLA investigators show that early exposure to a carbohydrate found in breast milk, called 2'FL, positively influences neurodevelopment.

Photoinitiators detected in human breast milk
Photoinitators (PIs) are compounds used in the ink of many types of food packaging.

Informal sharing of breast milk gains popularity among women, despite safety risks
Women who are unable to produce enough breast milk for their children are increasingly turning to 'mother-to-mother' informal milk-sharing, a potentially unsafe practice that is discouraged by the pediatric medical community, according to new research being presented at the American Academy of Pediatrics (AAP) 2019 National Conference & Exhibition.

Read More: Breast Milk News and Breast Milk Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.