New book reviews mechanisms of T-cell and B-cell activation

November 23, 2010

COLD SPRING HARBOR, N.Y. (Nov. 23, 2010) -- Specialized white blood cells called T cells and B cells are critical for immunity--helping the body to identify and eliminate "non-self" substances such as viruses and bacteria. The activation of T cells and B cells occurs when immunoreceptors on the cell surface bind to specific regions on, or derived from, the invaders. This binding activates signaling pathways inside the T cells and B cells that control cell survival, proliferation, differentiation, and effector functions.

A new book, Immunoreceptor Signaling, reviews our current understanding of events that occur during the activation of T cells and B cells. "The chapters cover a wide range of topics and, in aggregate, our hope is that they provide a comprehensive sense of the current state of the field," write the editors, Lawrence Samelson and Andrey Shaw, in the Preface. "Perhaps this overview will aid in stimulating the next many years of fruitful research."

Immunoreceptor Signaling, just released by Cold Spring Harbor Laboratory Press, includes contributions covering the structures of the T-cell and B-cell immunoreceptors, the numerous kinases and adaptors that associate with their intracellular tails, and the downstream signaling pathways that lead to transcription of interleukins and other outputs. Other contributions examine the roles of other receptors, co-stimulatory signals, and innate immune responses in regulation of immunoreceptor signaling.

The spatial organization of the immunological synapses connecting lymphocytes and antigen-presenting cells is also discussed, along with the role of the cytoskeleton in immunoreceptor function. Computational models of the signaling processes complete the volume, making it essential reading for systems biologists as well as all immunologists and cell biologists interested in understanding how lymphocytes function.
About the book:Immunoreceptor Signaling was edited by Lawrence E. Samelson (National Institute of Health) and Andrey Shaw (Washington University School of Medicine). It is published by Cold Spring Harbor Laboratory Press (ISBN 978-0-879698-96-6; © 2011) and is available in hardcover (282 pp., 7" × 10"). For more information, see

About Cold Spring Harbor Laboratory Press: Cold Spring Harbor Laboratory Press is an internationally renowned publisher of books, journals, and electronic media, located on Long Island, New York. Since 1933, it has furthered the advance and spread of scientific knowledge in all areas of genetics and molecular biology, including cancer biology, plant science, bioinformatics, and neurobiology. It is a division of Cold Spring Harbor Laboratory, an innovator in life science research and the education of scientists, students, and the public. For more information, visit

Cold Spring Harbor Laboratory

Related Transcription Articles from Brightsurf:

Circular RNA regulates neuronal differentiation by scaffolding an inhibitory transcription complex
In a screening for a functional impact to the neuronal differentiation process, Danish researchers identified a specific circular RNA, circZNF827, which surprisingly 'taps the brake' on neurogenesis.

Transcription factors may inadvertently lock in DNA mistakes
A team of Duke researchers has found that transcription factors have a tendency to bind strongly to ''mismatched'' sections of DNA, i.e. sections of the genome that were not copied correctly.

New role assigned to a human protein in transcription and genome stability
DNA-RNA hybrids, or R loops, are structures that generate genomic instability, a common feature of tumor cells.

CeMM study reveals how a master regulator of gene transcription operates
Using TPD technology, CeMM researchers set out to understand set out to understand the primary role of a key regulator of transcription, the human Mediator complex.

Researchers find new role for dopamine in gene transcription and cell proliferation
A joint group of researchers at the George Washington University and the University of Pittsburgh have found that dopamine and the dopamine D2 receptor modulate expression via the Wnt/β-catenin signaling pathway.

SMAD2 and SMAD3, two almost identical transcription factors but with distinct roles
Both transcription factors regulate the expression of genes involved in embryo development, among other functions, although they exert very different roles.

Study explores role of mediator protein complex in transcription and gene expression
A new study led by Ryerson University called 'The Med31 Conserved Component of the Divergent Mediator Complex in Tetrahymena thermophila Participates in Developmental Regulation' advances existing knowledge about transcription and gene expression.

New members found in a transcription factor complex that maintains beta cells
A protein complex in the nucleus of beta cells contains different proteins that work together to regulate genes important for the development and maintenance of functional beta cells.

Testifying while black: A linguistic analysis of disparities in court transcription
A new study has found that court reporters transcribe speakers of African American English significantly below their required level of accuracy.

HKUST scientists discover how RNA PoII maintains accurate transcription with super computer
Scientists from the Hong Kong University of Science and Technology have recently uncovered the mechanisms of how RNA polymerase II performs intrinsic cleavage reaction to proofread RNA transcriptions, shedding light on how misregulation of accurate transcription can lead to diseases including cancer and Alzheimer's disease.

Read More: Transcription News and Transcription Current Events is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to