Netupitant/palonosetron for prevention of nausea and vomiting: Added benefit not proven

November 23, 2015

The German Institute for Quality and Efficiency in Health Care (IQWiG) examined in a dossier assessment whether the drug combination netupitant/palonosetron (trade name: Akynzeo) offers an added benefit over the appropriate comparator therapy (ACT). The drug combination has been approved since May 2015 for the prevention of acute and delayed nausea and vomiting in adult patients receiving moderately or highly emetogenic (vomit-inducing) cancer chemotherapy. According to the findings, such an added benefit is not proven in moderately emetogenic or in highly emetogenic chemotherapeutic regimens.

Appropriate comparator therapy depends on type of chemotherapy

The Federal Joint Committee (G-BA) distinguished between two treatment situations in its commission: In moderately emetogenic chemotherapy, the added benefit of the new drug combination was to be examined in comparison with a dual combination of a serotonin antagonist and dexamethasone as ACT. In cisplatin-based chemotherapy, which is highly emetogenic, the specified ACT consisted of a triple combination, namely a serotonin antagonist, a neurokinin-1 receptor antagonist and, again, dexamethasone.

No evaluable data on moderately emetogenic chemotherapy

For the first research question (moderately emetogenic chemotherapy), the drug manufacturer presented data in its dossier from a study of direct comparison and from an indirect comparison, in which palonosetron had been used as serotonin antagonist. Both comparisons are unsuitable for the derivation of the added benefit because the study of direct comparison, which was also used for the indirect comparison, included patients receiving a combination chemotherapy classified as highly emetogenic in current guidelines.

In highly emetogenic chemotherapy, certain advantages only in side effects

For the second research question (highly emetogenic cisplatin-based chemotherapy), the manufacturer chose the triple combination palonosetron, aprepitant and dexamethasone from the allowed ACTs. In one relevant study (NETU-10-29), this drug combination had been compared with netupitant/palonosetron and dexamethasone in patients receiving moderately emetogenic chemotherapy and in patients receiving highly emetogenic chemotherapy. The analyses submitted in the dossier were conducted on the basis of the second subpopulation, which was relevant for the research question. The assessment was conducted based on the results during the entire study duration, i.e. across several cycles of chemotherapy.

There was no statistically significant difference and therefore no hint of an added benefit of netupitant/palonosetron versus the comparator therapy for the outcomes "all-cause mortality", "serious adverse events" and "treatment discontinuation due to adverse events". Health-related quality of life was not investigated, and there were no evaluable data for the outcome "nausea". Hence an added benefit is not proven for these 2 outcomes either.

For the outcome "vomiting", the manufacturer only presented results for the first chemotherapy cycle. These were inadequate for the derivation of an added benefit, particularly because mainly anti-emetogenic effects that last for several chemotherapy cycles are relevant for patients.

There was a statistically significant difference in favour of netupitant/palonosetron for the harm outcome "diarrhoea", and hence a hint of considerably lesser harm in comparison with the triple combination.

On its own, this positive effect regarding side effects cannot be interpreted in a meaningful way, however: Proof of equivalence in other outcome categories would be additionally required for the derivation of an added benefit. No data or no evaluable data or no sufficient data were available for this, however. Hence an added benefit of netupitant/palonosetron in comparison with the ACT is not proven for adult patients receiving highly emetogenic chemotherapy in the prevention and treatment of nausea and vomiting.
G-BA decides on the extent of added benefit

This dossier assessment is part of the early benefit assessment according to the Act on the Reform of the Market for Medicinal Products (AMNOG) supervised by the G-BA. After publication of the dossier assessment, the G-BA conducts a commenting procedure and makes a final decision on the extent of the added benefit.

An overview of the results of IQWiG's benefit assessment is given by a German-language executive summary. In addition, the website, published by IQWiG, provides easily understandable German-language information.

More English-language information will be available soon (Sections 2.1 to 2.5 of the dossier assessment as well as subsequently published health information on If you would like to be informed when these documents are available, please send an e-mail to

Institute for Quality and Efficiency in Health Care

Related Chemotherapy Articles from Brightsurf:

Chemotherapy is used to treat less than 25% of people with localized sarcoma
UCLA researchers have found that chemotherapy is not commonly used when treating adults with localized sarcoma, a rare type of cancer of the soft tissues or bone.

Starved cancer cells became more sensitive to chemotherapy
By preventing sugar uptake, researchers succeeded in increasing the cancer cells' sensitivity to chemotherapeutic treatment.

Vitamin D could help mitigate chemotherapy side effects
New findings by University of South Australia researchers reveal that Vitamin D could potentially mitigate chemotherapy-induced gastrointestinal mucositis and provide relief to cancer patients.

Less chemotherapy may have more benefit in rectal cancer
GI Cancers Symposium: Colorado study of 48 patients with locally advanced rectal cancer receiving neoadjuvant chemotherapy, found that patients receiving lower-than-recommended doses in fact saw their tumors shrink more than patients receiving the full dose.

Male fertility after chemotherapy: New questions raised
Professor Delb├Ęs, who specializes in reproductive toxicology, conducted a pilot study in collaboration with oncologists and fertility specialists from the McGill University Health Centre (MUHC) on a cohort of 13 patients, all survivors of pediatric leukemia and lymphoma.

'Combo' nanoplatforms for chemotherapy
In a paper to be published in the forthcoming issue in NANO, researchers from Harbin Institute of Technology, China have systematically discussed the recent progresses, current challenges and future perspectives of smart graphene-based nanoplatforms for synergistic tumor therapy and bio-imaging.

Nanotechnology improves chemotherapy delivery
Michigan State University scientists have invented a new way to monitor chemotherapy concentrations, which is more effective in keeping patients' treatments within the crucial therapeutic window.

Novel anti-cancer nanomedicine for efficient chemotherapy
Researchers have developed a new anti-cancer nanomedicine for targeted cancer chemotherapy.

Ending needless chemotherapy for breast cancer
A diagnostic test developed at The University of Queensland might soon determine if a breast cancer patient requires chemotherapy or would receive no benefit from this gruelling treatment.

A homing beacon for chemotherapy drugs
Killing tumor cells while sparing their normal counterparts is a central challenge of cancer chemotherapy.

Read More: Chemotherapy News and Chemotherapy Current Events is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to