Heating techniques could improve treatment of macular degeneration

November 23, 2019

SEATTLE, November 23, 2019 - Age-related macular degeneration is the primary cause of central vision loss and results in the center of the visual field being blurred or fully blacked out. Though treatable, some methods can be ineffective or cause unwanted side effects.

Jinglin Huang, a graduate student in medical engineering at Caltech, suggests inefficient fluid mixing of the injected medicine and the gel within the eye may be to blame. Huang will be discussing the effects of a thermally induced fluid mixing approach for AMD therapy during a session at the American Physical Society's Division of Fluid Dynamics 72nd Annual Meeting, which will take place on Nov. 23-26, 2019, at the Washington State Convention Center in Seattle.

The talk, "Thermal Effects on Fluid Mixing in the Eye," will be presented at 4:40 p.m. Pacific (U.S.) on Saturday, Nov. 23 in Room 612 as part of the session on biological fluid dynamics: microfluidics.

AMD usually starts as "dry" AMD, a disorder in which the macula -- the central part of the retina, responsible for sending information about focused light to the brain to create a detailed picture -- thins with age. Dry AMD is very common and is not treatable but may eventually evolve into "wet" AMD, which is more likely to result in vision loss. In wet AMD, abnormal blood vessels grow on the retina, leaking fluids under the macula. In the case of wet AMD, injections of medications called anti-vascular endothelial growth factor agents into the eye can help manage the disorder.

Huang said because the medication does not mix with the gel-like fluid in the eye -- the vitreous -- efficiently. Applying heat to the mixture can solve this problem.

"Because thermally induced mixing in the vitreous chamber can promote the formation of a circulation flow structure, this can potentially serve the drug delivery process," Huang said. "Since the half life of the drug is limited, this thermally induced mixing approach ensures that more drug of high potency can reach the target tissue."

To apply the thermally induced mixing technique, no changes in the injection procedure are needed. An additional heating step after the injection is all that is required.

"It can potentially reduce the amount of drug injected into the vitreous," said Huang. "It is definitely easy to be implemented."

Huang and her colleagues hope this work will inspire eye doctors to develop better treatment techniques and improve patient experiences.
-end-
MORE MEETING INFORMATION

USEFUL LINKS

Main meeting website: https://www.apsdfd2019.org/

Meeting technical program: http://meetings.aps.org/Meeting/DFD19/Content/3770

Invited talks: http://meetings.aps.org/Meeting/DFD19/APS_Invited

Hotel information: https://www.apsdfd2019.org/hotels

GALLERY OF FLUID DYNAMICS

At the Annual Meeting, The Gallery of Fluid Motion will consist of posters and videos submitted by attendees illustrating the science and beauty of fluid motion. More information can be found here: https://www.apsdfd2019.org/gallery-of-fluid-motion

PRESS REGISTRATION

We will grant free registration to credentialed journalists and professional freelance journalists. If you are a reporter and would like to attend, contact media@aps.org. We can also help with setting up interviews and obtaining images, sound clips or background information.

LIVE MEDIA WEBCAST

A press briefing featuring a selection of newsworthy research will be webcast live from the conference on Monday, Nov. 25. Times and topics to be announced. Members of the media should register in advance at https://webcast.apswebcasting.com/go/aps-nov25-19.

ABOUT DFD

The Division of Fluid Dynamics of the American Physical Society, established in 1947, exists for the advancement and diffusion of knowledge of the physics of fluids with special emphasis on the dynamical theories of the liquid, plastic and gaseous states of matter under all conditions of temperature and pressure. For more information about DFD, visit https://www.aps.org/units/dfd/.

ABOUT APS

The American Physical Society (APS) is a nonprofit membership organization working to advance and diffuse the knowledge of physics through its outstanding research journals, scientific meetings, and education, outreach, advocacy, and international activities. APS represents over 55,000 members, including physicists in academia, national laboratories, and industry in the United States and throughout the world. For more information about APS, visit https://www.aps.org/.

American Physical Society

Related Vision Loss Articles from Brightsurf:

Discovery holds potential for reversing vision loss
Scientists at the Oklahoma Medical Research Foundation have identified a compound that could reverse the vision loss that occurs when blood vessels in the eyes of premature infants and adults grow out of control.

Researchers develop cell injection technique that could help reverse vision loss
University of Toronto Engineering researchers have developed a new method of injecting healthy cells into damaged eyes.

Exercise can slow or prevent vision loss, study finds
Exercise can slow or prevent the development of macular degeneration and may benefit other common causes of vision loss, such as glaucoma and diabetic retinopathy, new research suggests.

Vision loss influences perception of sound
People with severe vision loss can less accurately judge the distance of nearby sounds, potentially putting them more at risk of injury.

Estimating adults at high risk for vision loss, evaluating care use
The estimated number of US adults at high risk for vision loss increased from 2002 to 2017 in this observational study based on national survey data.

For aging patients, one missed doctor's visit can lead to vision loss
Visit adherence plays an important role in outcomes for patients with age-related macular degeneration, a Penn Medicine study found.

Concordian examines the link between cognition and hearing or vision loss
Concordia researcher Natalie Phillips and her colleagues found that poor hearing especially was linked to declines in memory and executive function in otherwise relatively healthy, autonomous, community-dwelling older adults.

Artificial intelligence predicts treatment outcome for diabetes-related vision loss
A new approach that uses artificial intelligence to analyze retinal images could one day help doctors select the best treatment for patients with vision loss from diabetic macular edema.

Disruption of glucose transport to rods and cones shown to cause vision loss in RP
Ophthalmology researchers at the University of Louisville have discovered the loss of vision in RP is the result of a disruption in the flow of nourishing glucose to the rods and cones.

Experimental drug delivers one-two punch to vision loss
In studies with lab-grown human cells and in mice, Johns Hopkins Medicine researchers have found that an experimental drug may be twice as good at fighting vision loss as previously thought.

Read More: Vision Loss News and Vision Loss Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.