The 'Signal Cell' relaying microbiota signals discovered

November 25, 2019

Microorganisms are considered as dirty organism that threaten our health, decay food and cause inconvenience in our daily life. However, they are playing a critical role in making nutrients by metabolizing food, allowing all living creatures to live on. Especially, there are 2,000 kinds of microorganisms and several hundred trillions in figures living in our body. Most of these microorganisms live in digestive tracts but their effect is shown in our entire body. Recently, the research team of POSTECH (Pohang University of Science and Technology, President Moohwan Kim) discovered how microbiota transmit signals to entire body and control hematopoiesis in the bone marrow.

Professor Seung-Woo Lee, Research Professor Yunji Park, Master/PhD integrated program students, Seungwon Lee and Hyekang Kim of Division of Integrative Biosciences and Biotechnology from POSTECH described the mechanism how microbiota signals are sent to different organs. Also, they utilized imaging research to prove that CX3CR+ mononuclear cells contact hematopoietic progenitors for the first time in history. Their research is introduced as a featured content in the journal of the American Society of Hematology, Blood.

Recent researches on microorganism concluded that microbiota control biological phenomenon not only in digestive tracts but also in lung, liver, brain, bone marrow and other organs. But, none of them were able to define a mechanism for relaying microbiota signals to entire body or for producing immune cells by receiving microbiota signals.

Professor Lee and his research team focused on the fact that the microbiota regulate the immune system of our body by controlling hematopoiesis in the bone marrow to produce white blood cells. In this process, the team discovered that the microbiota signal including bacterial DNA is transferred to the bone marrow through bloodstream and CX3CR1+ mononuclear cells in the bone marrow recognize this signal.

They explained that when CX3CR1+ mononuclear cells recognize microbiota signals, they release signal substances called cytokines which control and stimulate body's defense system through the signal transduction. They also explained that cytokines control the number of hematopoietic progenitors or stimulate differentiation into myeloid lineages to make blood cells.

Furthermore, they verified that CX3CR1+ mononuclear cells contact hematopoietic progenitors at the perivascular region and they play as a signal receiving microbiota signals.

They discovered the hematopoiesis control mechanism which is controlled by cytokines produced when CX3CR1+ mononuclear cells recognize microbiota signals transferred to the bone marrow.

Professor Seung-Woo Lee commented, "For the first time, our research describes the mechanism that had not been explained how microbiota regulate not only digestive tracts but also entire body response. It might be possible to apply this study to control immune response in other parts of a body or to treat cancer and inflammatory disease via microbiota signal pathway.

This study was financially supported by National Research Foundation of Korea, Regional Leading Research Center, and Korea Ministry of Science and ICT under BK21 Plus project.
-end-


Pohang University of Science & Technology (POSTECH)

Related Bone Marrow Articles from Brightsurf:

Researchers identify the mechanism behind bone marrow failure in Fanconi anaemia
Researchers at the University of Helsinki and the Dana-Farber Cancer Institute have identified the mechanism behind bone marrow failure developing in children that suffer from Fanconi anaemia.

Nanoparticles can turn off genes in bone marrow cells
Using specialized nanoparticles, MIT engineers have developed a way to turn off specific genes in cells of the bone marrow, which play an important role in producing blood cells.

How stress affects bone marrow
Researchers from Tokyo Medical and Dental University (TMDU) identified the protein CD86 as a novel marker of infection- and inflammation-induced hematopoietic responses.

3D atlas of the bone marrow -- in single cell resolution
Stem cells located in the bone marrow generate and control the production of blood and immune cells.

Dangerous bone marrow, organ transplant complication explained
Scientists have discovered the molecular mechanism behind how the common cytomegalovirus can wreak havoc on bone marrow and organ transplant patients, according to a paper published in the journal Cell & Host Microbe.

Viagra shows promise for use in bone marrow transplants
Researchers at UC Santa Cruz have demonstrated a new, rapid method to obtain donor stem cells for bone marrow transplants using a combination of Viagra and a second drug called Plerixafor.

Bone marrow may be the missing piece of the fertility puzzle
A woman's bone marrow may determine her ability to start and sustain a pregnancy, report Yale researchers in PLOS Biology.

Cells that make bone marrow also travel to the womb to help pregnancy
Bone marrow-derived cells play a role in changes to the mouse uterus before and during pregnancy, enabling implantation of the embryo and reducing pregnancy loss, according to research published Sept.

Uncovering secrets of bone marrow cells and how they differentiate
Researchers mapped distinct bone marrow niche populations and their differentiation paths for the bone marrow factory that starts from mesenchymal stromal cells and ends with three types of cells -- fat cells, bone-making cells and cartilage-making cells.

Zebrafish help researchers explore alternatives to bone marrow donation
UC San Diego researchers discover new role for epidermal growth factor receptor in blood stem cell development, a crucial key to being able to generate them in the laboratory, and circumvent the need for bone marrow donation.

Read More: Bone Marrow News and Bone Marrow Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.