Risk of childhood obesity can be predicted at birth

November 28, 2012

A simple formula can predict at birth a baby's likelihood of becoming obese in childhood, according to a study published today in the open access journal PLOS ONE.

The formula, which is available as an online calculator, estimates the child's obesity risk based on its birth weight, the body mass index of the parents, the number of people in the household, the mother's professional status and whether she smoked during pregnancy.

The researchers behind the study hope their prediction method will be used to identify infants at high risk and help families take steps to prevent their children from putting on too much weight.

Childhood obesity is a leading cause of early type 2 diabetes and heart and circulatory disease, and is becoming more common in developed countries. According to NHS figures, 17 per cent of boys and 15 per cent of girls aged two to 15 in England are classified as obese.

The researchers developed the formula using data from a study set up in 1986 following 4000 children born in Finland. They initially investigated whether obesity risk could be assessed using genetic profiles, but the test they developed based on common genetic variations failed to make accurate predictions. Instead, they discovered that non-genetic information readily available at the time of birth was enough to predict which children would become obese. The formula proved accurate not just in the Finnish cohort, but in further tests using data from studies in Italy and the US.

"This test takes very little time, it doesn't require any lab tests and it doesn't cost anything," said Professor Philippe Froguel, from the School of Public Health at Imperial College London, who led the study.

"All the data we use are well-known risk factors for childhood obesity, but this is the first time they have been used together to predict from the time of birth the likelihood of a child becoming obese."

The 20 per cent of children predicted to have the highest risk at birth make up 80 per cent of obese children. The researchers suggest that services such as dieticians and psychologists could be offered to families with high-risk infants to help them prevent excessive weight gain.

"Once a young child becomes obese, it's difficult for them to lose weight, so prevention is the best strategy, and it has to begin as early as possible," said Professor Froguel. "Unfortunately, public prevention campaigns have been rather ineffective at preventing obesity in school-age children. Teaching parents about the dangers of over-feeding and bad nutritional habits at a young age would be much more effective."

Although common genetic variants did not prove to be helpful for predicting childhood obesity, the researchers say about one in 10 cases of obesity are caused by rare mutations that seriously affect appetite regulation. Tests for these mutations could become available to doctors in the next few years as the cost of DNA sequencing technology falls.
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The Imperial researchers conducted the study in collaboration with colleagues at the University of Oulu, Finland; Harvard University in the US and the University of Verona, Italy. The work was funded by the Medical Research Council, Imperial College London, the University of Oulu and Centre National de la Recherche Scientifique.

The obesity risk calculator is available online at http://files-good.ibl.fr/childhood-obesity/

For further information please contact: Sam Wong

Out of hours duty press officer: 44-7803-886-248

Notes to editors

1. Reference: A Morandi et al. 'Estimation of newborn risk for child or adolescent obesity: lessons from longitudinal birth cohorts' PLOS ONE 28 November 2012.
After embargo link: http://dx.plos.org/10.1371/journal.pone.0049919

2. About Imperial College London

Consistently rated amongst the world's best universities, Imperial College London is a science-based institution with a reputation for excellence in teaching and research that attracts 14,000 students and 6,000 staff of the highest international quality. Innovative research at the College explores the interface between science, medicine, engineering and business, delivering practical solutions that improve quality of life and the environment - underpinned by a dynamic enterprise culture.

Since its foundation in 1907, Imperial's contributions to society have included the discovery of penicillin, the development of holography and the foundations of fibre optics. This commitment to the application of research for the benefit of all continues today, with current focuses including interdisciplinary collaborations to improve global health, tackle climate change, develop sustainable sources of energy and address security challenges.

In 2007, Imperial College London and Imperial College Healthcare NHS Trust formed the UK's first Academic Health Science Centre. This unique partnership aims to improve the quality of life of patients and populations by taking new discoveries and translating them into new therapies as quickly as possible.

Website: www.imperial.ac.uk

3. For almost 100 years the Medical Research Council has improved the health of people in the UK and around the world by supporting the highest quality science. The MRC invests in world-class scientists. It has produced 29 Nobel Prize winners and sustains a flourishing environment for internationally recognised research. The MRC focuses on making an impact and provides the financial muscle and scientific expertise behind medical breakthroughs, including one of the first antibiotics penicillin, the structure of DNA and the lethal link between smoking and cancer. Today MRC funded scientists tackle research into the major health challenges of the 21st century. www.mrc.ac.uk

Imperial College London

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