World first trial to test human implant of HeartPOD™

November 30, 2005

Researchers at The Alfred and Monash University are leading a world first trial to investigate whether the implantation of a specially designed HeartPODTM monitoring system in heart failure patients can keep them out of hospital and lead to a better quality of life.

The study, known as the HOMEOSTASIS study, aims to evaluate the safety and performance of the HeartPODTM system, which is designed to monitor and detect worsening congestive heart failure before the onset of symptoms and provide early preventative treatment, thus avoiding emergency hospitalisation.

For the first time ever, the system enables heart failure patients to personally monitor their condition and adjust their medication themselves without having to visit a doctor each time.

It is comprised of a permanently implanted sensor system that is designed to measure the pressure in the left atrium, the core body temperature and the electrical conduction of the heart. It is implanted in the patients' left atrial chamber by a cardiac catheterization procedure.

The sensor system sends information about the way the heart is working by wireless transmission to a handheld computer, which then analyses the signals and tells the patient what medications to take and when to take them.

This is a world first study of the HeartPODTM device being implanted into people, with 16 implants including four at The Alfred already completed. The trial will involve a minimum of 20 patients from four investigation sites across Australia and New Zealand.

Principal researcher and Head of Clinical Pharmacology at The Alfred and Monash University, Professor Henry Krum, said that the current treatment for congestive heart failure patients involved having to wait until the patient presented with symptoms that their condition was deteriorating and by that stage, the patient had usually been admitted to hospital.

"Unfortunately, we currently need to wait until the patient has respiratory distress or breathlessness, reduced exercise capacity, swelling of the ankles, fatigue or weakness before we can adjust their medications," said Professor Krum.

"Often by the time symptoms occur it is too late and the patient is in a situation where they require emergency hospitalisation to control their condition."

Co-principal investigator Dr Tony Walton, who performs the implants, said direct measurements from the heart by the HeartPODTM system may provide an accurate, reliable and medically acceptable way of telling the patient that the congestive heart failure is worsening, often hours to days before the symptoms would develop.

"This will then enable the patients to take preventative measures and avoid hospitalisation," he said.

People involved in the study have congested heart failure - a condition in which the heart's ability to pump properly is reduced. Congestive heart failure is usually a chronic disease, which means that it's a long-term condition that tends to become gradually worse.
-end-
Patients with congestive heart failure who have advanced disease and have been hospitalized for it in the last year who are interested in taking part in the trial should contact Jane Brack on 61-39-207-1931.

HeartPOD TM, developed and manufactured by Savacor, is a precision scientific instrument designed to withstand the rigors of up to decades of operation from within the human heart. It is not based on the consumer electronics product iPOD.

Interview opportunities:For more information phone The Alfred Public Affairs on 61-39-276-2266 or Monash University on 61-39-905-9315

Research Australia

Related Congestive Heart Failure Articles from Brightsurf:

Top Science Tip Sheet on heart failure, heart muscle cells, heart attack and atrial fibrillation results
Newly discovered pathway may have potential for treating heart failure - New research model helps predict heart muscle cells' impact on heart function after injury - New mass spectrometry approach generates libraries of glycans in human heart tissue - Understanding heart damage after heart attack and treatment may provide clues for prevention - Understanding atrial fibrillation's effects on heart cells may help find treatments - New research may lead to therapy for heart failure caused by ICI cancer medication

Machining the heart: New predictor for helping to beat chronic heart failure
Researchers from Kanazawa University have used machine learning to predict which classes of chronic heart failure patients are most likely to experience heart failure death, and which are most likely to develop an arrhythmic death or sudden cardiac death.

Heart attacks, heart failure, stroke: COVID-19's dangerous cardiovascular complications
A new guide from emergency medicine doctors details the potentially deadly cardiovascular complications COVID-19 can cause.

Autoimmunity-associated heart dilation tied to heart-failure risk in type 1 diabetes
In people with type 1 diabetes without known cardiovascular disease, the presence of autoantibodies against heart muscle proteins was associated with cardiac magnetic resonance (CMR) imaging evidence of increased volume of the left ventricle (the heart's main pumping chamber), increased muscle mass, and reduced pumping function (ejection fraction), features that are associated with higher risk of failure in the general population

Beta blocker use identified as hospitalization risk factor in 'stiff heart' heart failure
A new study links the use of beta-blockers to heart failure hospitalizations among those with the common 'stiff heart' heart failure subtype.

Toilet seat that detects congestive heart failure getting ready to begin commercialization
A toilet-seat based cardiovascular monitoring system created by a team of Rochester Institute of Technology researchers aims to lower the hospital readmission rates of patients with congestive heart failure.

Novel heart pump shows superior outcomes in advanced heart failure
Severely ill patients with advanced heart failure who received a novel heart pump -- the HeartMate 3 left ventricular assist device (LVAD) -- suffered significantly fewer strokes, pump-related blood clots and bleeding episodes after two years, compared with similar patients who received an older, more established pump, according to research presented at the American College of Cardiology's 68th Annual Scientific Session.

NSAID impairs immune response in heart failure, worsens heart and kidney damage
Non-steroidal anti-inflammatory drugs, or NSAIDs, are widely known as pain-killers and can relieve pain and inflammation.

Oxygen therapy for patients suffering from a heart attack does not prevent heart failure
Oxygen therapy does not prevent the development of heart failure.

Epigenetic reprogramming of human hearts found in congestive heart failure
Congestive heart failure is a terminal disease that affects nearly 6 million Americans.

Read More: Congestive Heart Failure News and Congestive Heart Failure Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.