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Researchers identify cause for lower-extremity overgrowths in obese patients

November 30, 2016

CHICAGO (November 30, 2016): Morbidly obese individuals--those whose weight is more than double normal weight--are prone to overgrowths in their lower extremities that can lead to infections and other health-threatening complications. Little was previously known about the underlying causes of this condition, and conventional treatment has involved surgical removal of these overgrowths. However, a new study published online as an "article in press" ahead of print in the Journal of the American College of Surgeons has identified the underlying cause for these overgrowths, and the researchers recommend that weight loss, not a surgical procedure, be the preferred initial treatment for these patients.

The researcher team, led by Arin K. Greene, MD, MMSc, FACS, a plastic surgeon at Boston Children's Hospital, Harvard Medical School, developed a probability scale that can help physicians identify patients at greatest risk of this condition, known as massive localized lymphedema (MLL). This study is the first to identify the cause of MLL as obesity-induced lymphedema (OIL), and it builds upon previous work Dr. Greene and colleagues have published in which they identified OIL as a disease resulting from obesity.*

"The major clinical takeaway for physicians is that if they have a patient with massive localized lymphedema, the individual has an underlying disease called obesity-induced lymphedema and the initial treatment should be weight loss," Dr. Greene said. "Surgeons should consider removing one of these massive growths only after the patient has lost significant weight, because the risk of recurrence is lower and the operation is much safer."

Body-mass index (BMI) is a measure that determines an individual's weight status. It is the ratio of one's weight in kilograms to the square of height in meters (kg/m2). BMI of 25 kg/m2 is considered normal, between 25.1 and 29.9 kg/m2 overweight, and 30 kg/m2 or greater obese. Once an individual's BMI exceeds 50 kg/m2, the lymphatic system in the legs becomes damaged and patients develop lower extremity swelling, known as obesity-induced lymphedema. Over time, massive overgrowths can occur in these patients; the higher the BMI, the greater the risk.

The Boston Children's-Harvard study involved 82 obese patients who underwent lymphoscintigraphy, a nuclear medicine test for evaluating lymph drainage, to evaluate lower extremity lymphatic function between 2009 and 2016. Seventeen were diagnosed with MLL, and all of them had underlying OIL. Their median BMI was 66 kg/m2, ranging from 62 to 78 kg/m2, with a median age of 61 years (median age of controls who did not have MLL was 55 years). Patients with a BMI greater than 56 kg/m2 had a 213 greater odds of developing MLL than patients with lower BMI. Dr. Greene pointed out that lymphoscintigraphy "is very accurate in determining if the lymphatic vessels in the lower extremities are functioning properly."

"An important finding of the study is that we can now counsel patients with OIL who have not yet developed MLL about the likelihood that they will develop MLL if they do not lose weight," Dr. Greene said. The study researchers developed a probability scale that identifies a patient's risk for developing MLL: a 4 percent chance at 40 kg/m2; 15 percent at 50 kg/m2; 40 percent at 60 kg/m2; 75 percent at 70 kg/m2; and 92 percent at 80 kg/m2.

The key is that morbidly obese patients with significant MLL overgrowths should undergo counseling for weight loss--non-surgical at first, then bariatric surgery if that fails--before undergoing an operation to remove the MLL overgrowths. "In our center, individuals with obesity-induced lymphedema, with or without MLL, are referred to a bariatric surgical center to treat the underlying cause of their lymphatic function, which is their weight," Dr. Greene said. "Not only will weight reduction prevent the occurrence of MLL, but it will significantly shrink the area of overgrowth and facilitate its resection."
Study coauthors are Reid Maclellan, MD, MMSC, of the Department of Plastic and Oral Surgery; David Zurakowski, PhD, of the Department of Anesthesia; and Frederick D. Grant, MD, of the Department of Radiology, Division of Nuclear Medicine, all at Boston Children's Hospital, Harvard Medical School.

Note: "FACS" designates that a surgeon is a Fellow of the American College of Surgeons.

Citation: Massive Localized Lymphedema: A Case-Control Study. Journal of the American College of Surgeons.

* Greene AK, Grant FD, Slavin SA. Lower-Extremity Lymphedema and Elevated Body-Mass Index. N Engl J Med. 2012; 366:2136-2137.

About the American College of Surgeons

The American College of Surgeons is a scientific and educational organization of surgeons that was founded in 1913 to raise the standards of surgical practice and improve the quality of care for surgical patients. The College is dedicated to the ethical and competent practice of surgery. Its achievements have significantly influenced the course of scientific surgery in America and have established it as an important advocate for all surgical patients. The College has more than 80,000 members and is the largest organization of surgeons in the world. For more information, visit

American College of Surgeons

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