Nav: Home

Patients with cancer are more at risk of complications following heart procedure

November 30, 2018

Research led by Keele University suggests that patients with cancer who undergo a common heart procedure have worse short-term clinical outcomes compared to non-cancer patients, in the largest study undertaken to date.

The study, published today in the European Heart Journal, looked at 6.6 million hospital admissions in the USA over an 11-year period, in which the admitted patient underwent a percutaneous coronary intervention (PCI) procedure.

PCI is the most common interventional treatment undertaken in patients with coronary heart disease, and is a procedure in which a stent is used to open up narrowed or blocked blood vessels in the heart, both as a planned procedure or in the emergency heart attack setting.

Approximately 10% of the patients who underwent a PCI procedure during the 11-year period analysed had either a current or historical cancer diagnosis.

The study specifically looked at the impact on patients with a diagnosis of prostate, breast, colon or lung cancer, as these were the most prevalent in the dataset.

The study found that patients with a current diagnosis of lung cancer were three times more likely to die in hospital following a PCI procedure, compared to patients with no cancer. Colon cancer had the greatest association with major bleeding complications post-PCI, with a threefold increase compared to patients with no cancer. Patients with metastatic cancer, irrespective of cancer type, were found to have poorer outcomes following a PCI, and were at increased risk of dying in hospital, and suffering PCI complications, including major bleeding events.

Professor Mamas Mamas, Professor of Cardiology at Keele University who led the study commented:

"Our research found that a concurrent cancer diagnosis during these procedures is not uncommon, and it has an important impact on the clinical outcomes of these procedures, depending on the type of cancer, presence of metastases, and whether the diagnosis is historical or current.

"This research is important because there is limited data regarding outcomes of patients undergoing PCI with a current or historical diagnosis of cancer. Such patients are often excluded from randomised controlled trials, and cancer history is not captured in national PCI registries. Clinicians are often unsure what the risks of these procedures are in these patients, and how best the procedures should be undertaken."

Dr Jessica Potts, Research Associate at Keele University and co-author of the study, commented:

"Our recommendation is that treatment of patients with a cancer diagnosis should be individualised, recognising that cancer is associated with a higher risk of complications, and should involve a close collaboration between cardiologists and oncologists."
-end-


Keele University

Related Lung Cancer Articles:

AI helps to fight against lung cancer
Lung cancer has been the leading cause of cancer-related deaths in 2015 in United States.
Free lung-cancer screening in the Augusta area finds more than double the cancer rate of previous screenings
The first year of free lung cancer screening in the Augusta, Ga., area found more than double the rate seen in a previous large, national study as well as a Massachusetts-based screening for this No.
Antioxidants and lung cancer risk
An epidemiological study published in Frontiers in Oncology suggests that a diet high in carotenoids and vitamin C may protect against lung cancer.
Lung cancer may go undetected in kidney cancer patients
Could lung cancer be hiding in kidney cancer patients? Researchers with the Harold C.
Hitgen and Cancer Research UK's Manchester Institute enter license agreement in lung cancer
Cancer Research UK, Cancer Research Technology (CRT), the charity's commercial arm, and HitGen Ltd, a privately held biotech company focused on early drug discovery, announced today that they have entered into a licence agreement to develop a novel class of drugs against lung cancer.
Radiotherapy for invasive breast cancer increases the risk of second primary lung cancer
East Asian female breast cancer patients receiving radiotherapy have a higher risk of developing second primary lung cancer.
Huntsman Cancer Institute research holds promise for personalized lung cancer treatments
New research from scientists at Huntsman Cancer Institute (HCI) at the University of Utah uncovered distinct types of tumors within small cell lung cancer that look and act differently from one another.
High levels of estrogen in lung tissue related to lung cancer in postmenopausal women
Researchers from Kumamoto University, Japan have found that postmenopausal women with multicentric adenocarcinoma of the lung have a higher concentration of estrogen in non-cancerous areas of the peripheral lung than similar women diagnosed with single tumor lung cancer.
Radiotherapy for lung cancer patients is linked to increased risk of non-cancer deaths
Researchers have found that treating patients who have early stage non-small cell lung cancer with a type of radiotherapy called stereotactic body radiation therapy is associated with a small but increased risk of death from causes other than cancer.
Pericardial window operation less efficient in cases of lung cancer than any other cancer
Pericardial window operation, a procedure, where abnormal quantity of malignant fluid, surrounding the heart, is drained into the neighbouring chest cavity, is commonly applied to patients diagnosed with cancer.

Related Lung Cancer Reading:

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Bias And Perception
How does bias distort our thinking, our listening, our beliefs... and even our search results? How can we fight it? This hour, TED speakers explore ideas about the unconscious biases that shape us. Guests include writer and broadcaster Yassmin Abdel-Magied, climatologist J. Marshall Shepherd, journalist Andreas Ekström, and experimental psychologist Tony Salvador.
Now Playing: Science for the People

#513 Dinosaur Tails
This week: dinosaurs! We're discussing dinosaur tails, bipedalism, paleontology public outreach, dinosaur MOOCs, and other neat dinosaur related things with Dr. Scott Persons from the University of Alberta, who is also the author of the book "Dinosaurs of the Alberta Badlands".