Moderate to severe sleep-disordered breathing can lead to stroke

December 01, 2005

Individuals who experience moderate to severe sleep-disordered breathing are four times more likely to have a stroke during the next four years than those who do not suffer from the problem.

These findings were reported in the first issue of the December 2005 American Journal of Respiratory and Critical Care Medicine, published by the American Thoracic Society.

T. Douglas Bradley, M.D., of the Toronto General Hospital/ University Health Network, Toronto, Canada, together with four associates, analyzed research results from 1,475 participants who were tested for sleep-disordered breathing at the University of Wisconsin General Clinical Research Center, Madison. Follow-up visits were conducted over the next 4, 8, and 12 years. Among the group, 21 individuals suffered a first-ever stroke at an average age of 53.

"Our longitudinal analysis provides the first prospective evidence that sleep-disordered breathing after adjustment for age and sex is related to significantly increased odds of suffering a stroke over the next 4 years," said Dr. Bradley. "Although our analysis cannot shed light on the pathway by which sleep-disordered breathing affects stroke risk, these novel findings add justification to considering the problem as a condition that either precedes or may contribute to the development of stroke."

Sleep-disordered breathing is one of a group of serious sleep disorders in which a sleeping person repeatedly stops breathing long enough to reduce the amount of oxygen in the blood and to increase the amount of carbon dioxide. Researchers categorize its severity by counting the "events" per hour that a person stops breathing for 10 seconds or more. Moderate to severe sleep disordered breathing is defined as 20 or more "events" per hour.

During the study and follow-up visits, participants underwent a laboratory sleep test (polysomnography), along with measurement of blood pressure and serum cholesterol levels, together with a check of other stroke risk factors such as body mass index.

Among the 1,475 participants, 76 percent (1,121) did not have sleep-disordered breathing (less than 5 "events" per hour), 17 percent (251) had a mild disorder (5 to 19 "events"), and 7 percent (103) had a moderate to severe problem.

Dr. Bradley noted that stroke is an important public health issue since it constitutes the commonest cause of long-term disability in the United States. It affects more than 1.1 million persons, with direct and indirect costs estimated at $56.8 billion for 2005.

In the future, Dr. Bradley believes that randomized clinical trials will be required to determine whether treatment for sleep-disordered breathing could either prevent stroke or improve its outcome.
-end-
Contact:
T. Douglas Bradley, M.D.
Senior Investigator at Toronto Rehab,
Director of Toronto General Hospital's Sleep Research Laboratory
EC 6-248
200 Elizabeth Street
Toronto, Ontario M5G 2C4, Canada
Phone: 416-340-4719
E-mail: douglas.bradley@utoronto.ca

American Thoracic Society

Related Stroke Articles from Brightsurf:

Stroke alarm clock may streamline and accelerate time-sensitive acute stroke care
An interactive, digital alarm clock may speed emergency stroke care, starting at hospital arrival and through each step of the time-sensitive treatment process.

Stroke patients with COVID-19 have increased inflammation, stroke severity and death
Stroke patients who also have COVID-19 showed increased systemic inflammation, a more serious stroke severity and a much higher rate of death, compared to stroke patients who did not have COVID-19, according a retrospective, observational, cross-sectional study of 60 ischemic stroke patients admitted to UAB Hospital between late March and early May 2020.

'Time is vision' after a stroke
University of Rochester researchers studied stroke patients who experienced vision loss and found that the patients retained some visual abilities immediately after the stroke but these abilities diminished gradually and eventually disappeared permanently after approximately six months.

More stroke awareness, better eating habits may help reduce stroke risk for young adult African-Americans
Young African-Americans are experiencing higher rates of stroke because of health conditions such as high blood pressure, diabetes and obesity, yet their perception of their stroke risk is low.

How to help patients recover after a stroke
The existing approach to brain stimulation for rehabilitation after a stroke does not take into account the diversity of lesions and the individual characteristics of patients' brains.

Kids with headache after stroke might be at risk for another stroke
A new study has found a high incidence of headaches in pediatric stroke survivors and identified a possible association between post-stroke headache and stroke recurrence.

High stroke impact in low- and middle-income countries examined at 11th World Stroke Congress
Less wealthy countries struggle to meet greater need with far fewer resources.

Marijuana use might lead to higher risk of stroke, World Stroke Congress to be told
A five-year study of hospital statistics from the United States shows that the incidence of stroke has risen steadily among marijuana users even though the overall rate of stroke remained constant over the same period.

We need to talk about sexuality after stroke
Stroke survivors and their partners are not adequately supported to deal with changes to their relationships, self-identity, gender roles and intimacy following stroke, according to new research from the University of Sydney.

Standardized stroke protocol can ensure ELVO stroke patients are treated within 60 minutes
A new study shows that developing a standardized stroke protocol of having neurointerventional teams meet suspected emergent large vessel occlusion (ELVO) stroke patients upon their arrival at the hospital achieves a median door-to-recanalization time of less than 60 minutes.

Read More: Stroke News and Stroke Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.