Nav: Home

Jawbone loss predates rheumatoid arthritis

December 01, 2017

Jawbone loss caused by periodontitis predates the onset of rheumatoid arthritis. This according to research from Umeå University in Sweden presented in the journal Arthritis & Rheumatology. The research also shows a causal relationship between jawbone loss and elevated levels of the bone resorption inducing molecule RANKL in the blood.

Jawbone loss caused by inflammation is characteristic to both periodontitis - a disease leading to tooth loss - and rheumatoid arthritis. Despite differences in what causes the inflammation in periodontitis or rheumatoid arthritis, it has now been established that there is a correlation between the two.

"For example, it's known that individuals with rheumatoid arthritis to a great extent show symptoms of tooth loss than individuals with healthy joints. It's also been known that treatments aimed at periodontitis also ease symptoms from joints in individuals with rheumatoid arthritis. What's not been proven so far, however, is a causal relationship between the two," says Pernilla Lundberg, senior lecturer at the Department of Odontology at Umeå University, and one of the researchers behind the study.

In a collaboration, Pernilla Lundberg and Solbritt Rantapää-Dahlqvist, who is a researcher at the Department of Public Health and Clinical Medicine at Umeå University, have analysed the prevalence of jawbone loss in dental x-rays of individuals with rheumatoid arthritis. The X-rays were performed before arthritis symptoms had developed, and were compared with X-rays from matching controls. All participants in the study had on numerous occasions donated blood to the Medical Biobank Northern Sweden Health and Disease Study. Dental X-rays had been retrieved from the treating dentists.

The results, now presented in the journal Arthritis & Rheumatology, show for the first time that the individuals who later develop rheumatoid arthritis to a greater degree show signs of jawbone loss. Individuals with rheumatoid arthritis also to a greater extent develop jawbone loss over time. Among the individuals who later developed rheumatoid arthritis, the greatest degree of bone loss was detected in individuals who also showed elevated levels of the bone resorption inducing molecule RANKL in the blood.

"As far as we know, no one has previously been able to show that individuals who later develop rheumatoid arthritis have a higher degree of jawbone loss before showing any symptoms of arthritis," says Solbritt Rantapää-Dahlqvist.

"Our results indicate a causal relationship between periodontitis and rheumatoid arthritis. Nevertheless, further clinical studies and studies on basic mechanisms are needed in order to prove the existence of a causal relationship with certainty."
-end-
For more information, please contact:

Pernilla Lundberg
Department of Odontology
Umeå University
46-70-549-5356
pernilla.lundberg@umu.se

Solbritt Rantapää Dahlqvist
Department of Public Health and Clinical Medicine
Umeå University
46-90-785-17-29
solbritt.rantapaa.dahlqvist@umu.se

About the publication:

Arthritis & Rheumatology, article: Marginal jawbone loss is associated with onset of rheumatoid arthritis and is related to plasma level of receptor activator of nuclear factor kappa-B-ligand (RANKL). Authors: Kindstedt E, Johansson L, Palmqvist P, Koskinen-Holm C, Kokkonen H, Johansson I, Rantapää Dahlqvist S, and Lundberg P. DOI: 10.1002/art.40394.

Umea University

Related Rheumatoid Arthritis Articles:

Rheumatoid arthritis -- can its onset be delayed or prevented?
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disorder that leads to significant health issues as well as high treatment costs.
Disease burden in osteoarthritis is similar to rheumatoid arthritis
Osteoarthritis (OA) has traditionally been viewed as a highly prevalent but milder condition when compared with rheumatoid arthritis (RA), and some may believe that it is part of a normal aging process requiring acceptance, not treatment.
Prospect of a new treatment for rheumatoid arthritis
An international research group led by Charité -- Universitätsmedizin Berlin has completed testing a new drug to treat rheumatoid arthritis.
Can rare lymphocytes combat rheumatoid arthritis?
Immunologists at Friedrich-Alexander-Universität Erlangen-Nürnberg have demonstrated that ILC2, a group of rare lymphoid cells, play a key role in the development of inflammatory arthritis.
How environmental pollutants and genetics work together in rheumatoid arthritis
New research documents how chemicals and a certain gene activate an enzyme to increase the risk and severity of RA and bone destruction.
Rheumatoid arthritis meets precision medicine
Scientists are bringing precision medicine to rheumatoid arthritis for the first time by using genetic profiling of joint tissue to see which drugs will work for which patients, reports a new multi-site study.
Causes of death in rheumatoid arthritis patients
Mortality rates were increased for patients with rheumatoid arthritis relative to the general population across all causes of death in a recent Arthritis Care & Research analysis.
Menopause found to worsen symptoms of rheumatoid arthritis
A recent study published in Rheumatology suggests that women with rheumatoid arthritis suffer a greater decline in physical function following menopause.
Jawbone loss predates rheumatoid arthritis
Jawbone loss caused by periodontitis predates the onset of rheumatoid arthritis.
Gel to fight rheumatoid arthritis
IBS scientists developed a potentially therapeutic gel, which detects nitric oxide, absorbs excess fluids and delivers drugs.
More Rheumatoid Arthritis News and Rheumatoid Arthritis Current Events

Top Science Podcasts

We have hand picked the top science podcasts of 2019.
Now Playing: TED Radio Hour

Risk
Why do we revere risk-takers, even when their actions terrify us? Why are some better at taking risks than others? This hour, TED speakers explore the alluring, dangerous, and calculated sides of risk. Guests include professional rock climber Alex Honnold, economist Mariana Mazzucato, psychology researcher Kashfia Rahman, structural engineer and bridge designer Ian Firth, and risk intelligence expert Dylan Evans.
Now Playing: Science for the People

#541 Wayfinding
These days when we want to know where we are or how to get where we want to go, most of us will pull out a smart phone with a built-in GPS and map app. Some of us old timers might still use an old school paper map from time to time. But we didn't always used to lean so heavily on maps and technology, and in some remote places of the world some people still navigate and wayfind their way without the aid of these tools... and in some cases do better without them. This week, host Rachelle Saunders...
Now Playing: Radiolab

Dolly Parton's America: Neon Moss
Today on Radiolab, we're bringing you the fourth episode of Jad's special series, Dolly Parton's America. In this episode, Jad goes back up the mountain to visit Dolly's actual Tennessee mountain home, where she tells stories about her first trips out of the holler. Back on the mountaintop, standing under the rain by the Little Pigeon River, the trip triggers memories of Jad's first visit to his father's childhood home, and opens the gateway to dizzying stories of music and migration. Support Radiolab today at Radiolab.org/donate.