Congenital heart defects affects long-term developmental outcome

December 02, 2013

Approximately one percent of all newborns in Switzerland are diagnosed with a congenital heart defect, roughly half of them require open heart surgery. Most children, including those with the most severe heart defects, survive because of the significant advancements in surgical techniques. Therefore, the current research focuses less on survival than on long-term consequences and quality of life of these children.

Aside from cardiac complications, developmental problems may emerge after a complex cardiac surgical procedure. Children may suffer from motor, language or learning difficulties. The etiology of these problems is multifactorial and the association with the surgical procedure, which affects systemic circulation and can impair cerebral blood flow, is not clear. For the first time, researchers from the Children's Hospital Zurich demonstrate that morphological changes of the brain can be detected many years after open-heart surgery and can have a long-term impact on brain development. However, the researchers also discovered that brain changes may already exist before the cardiac surgery. This indicates that the neurological risks associated with the cardiac surgery itself are smaller than previously believed.

Smaller brain volume with severe heart defects

Under the supervision of the pediatrician Bea Latal, the postdoctoral student Michael von Rhein studied a group of 39 14-year-old congenital heart patients who had undergone open-heart surgery during early childhood in the late 1990s. The adolescents underwent extensive testing of cognitive and motor skills and the brain volume as well as specific brain regions, were measured using cerebral magnetic resonance imaging. "It became evident that these former cardiac patients had around 10 percent less brain volume than healthy young people," explains von Rhein. Patients with severe congenital heart defects were most affected by this volume loss.

The researchers were also able to demonstrate that adolescents with congenital heart defects were more likely to exhibit learning and motor difficulties than healthy control people.

These difficulties were more pronounced in those with smaller brain volumes. Despite these difficulties, however, most of adolescent patients were able to attend regular school and their quality of life was not impaired.

In another, recently published study, the developmental pediatrician Bea Latal and pediatric cardiologist Walter Knirsch from the Children's Hospital Zurich revealed that the development of children with a congenital heart defect can be delayed prior to surgery and that mild cerebral changes can occur- long before the life-saving heart surgery is performed. "Evidently, the changes in the brain that are detectable at such an early time persist and may influence further development into adolescence," concludes Latal from the results of the study.

M. von Rhein, A. Buchmann, R. Huber, P. Klaver, C. Hagmann, W. Knirsch, B. Latal. Smaller brain volume correlates with neurodevelopmental function in adolescents after bypass repair for congenital heart disease. Brain, November 25th 2013, doi:10.1093/brain/awt322

S. Bertholdt, B. Latal, R. Liamlahia, I. Scheer, R. Prêtre, R. Goetti, H. Dave, V. Bernet, A. Schmitz, M. von Rhein, W. Knirsch, and the Research Group Heart and Brain. Cerebral lesions on MRI correlate with preoperative neurological status in neonates undergoing cardiopulmonary bypass surgery. European Journal of Cardio-Thoracic Surgery, 2013, doi:10.1093/ejcts/ezt422

C. Schaefer, M. von Rhein, W. Knirsch, R. Huber, G. Natalucci, J. Caflisch, M. Landolt, B. Latal B. Neurodevelopmental outcome, behavior and quality of life in adolescents with congenital heart disease. Dev Med Child Neuro. 2013, doi: 10.1111/dmcn.12242


The currently published studies are part of the interdisciplinary research group "Heart and Brain" at the University Children's Hospital Zurich. In this group, clinical and basic scientists combine their efforts to better understand the causes, course and treatment of developmental disorders in children with congenital heart disease. The aim is to optimize care for these children and their families, identify potential risk factors and provide early therapeutic interventions. In combination with the very good surgical and perioperative care, these findings will hopefully allow children with congenital heart defects to lead a normal life.


PD Dr. med. Beatrice Latal
Child Development Center
Children's Hospital Zurich
Tel. +41 44 266 77 51

University of Zurich

Related Brain Articles from Brightsurf:

Glioblastoma nanomedicine crosses into brain in mice, eradicates recurring brain cancer
A new synthetic protein nanoparticle capable of slipping past the nearly impermeable blood-brain barrier in mice could deliver cancer-killing drugs directly to malignant brain tumors, new research from the University of Michigan shows.

Children with asymptomatic brain bleeds as newborns show normal brain development at age 2
A study by UNC researchers finds that neurodevelopmental scores and gray matter volumes at age two years did not differ between children who had MRI-confirmed asymptomatic subdural hemorrhages when they were neonates, compared to children with no history of subdural hemorrhage.

New model of human brain 'conversations' could inform research on brain disease, cognition
A team of Indiana University neuroscientists has built a new model of human brain networks that sheds light on how the brain functions.

Human brain size gene triggers bigger brain in monkeys
Dresden and Japanese researchers show that a human-specific gene causes a larger neocortex in the common marmoset, a non-human primate.

Unique insight into development of the human brain: Model of the early embryonic brain
Stem cell researchers from the University of Copenhagen have designed a model of an early embryonic brain.

An optical brain-to-brain interface supports information exchange for locomotion control
Chinese researchers established an optical BtBI that supports rapid information transmission for precise locomotion control, thus providing a proof-of-principle demonstration of fast BtBI for real-time behavioral control.

Transplanting human nerve cells into a mouse brain reveals how they wire into brain circuits
A team of researchers led by Pierre Vanderhaeghen and Vincent Bonin (VIB-KU Leuven, Université libre de Bruxelles and NERF) showed how human nerve cells can develop at their own pace, and form highly precise connections with the surrounding mouse brain cells.

Brain scans reveal how the human brain compensates when one hemisphere is removed
Researchers studying six adults who had one of their brain hemispheres removed during childhood to reduce epileptic seizures found that the remaining half of the brain formed unusually strong connections between different functional brain networks, which potentially help the body to function as if the brain were intact.

Alcohol byproduct contributes to brain chemistry changes in specific brain regions
Study of mouse models provides clear implications for new targets to treat alcohol use disorder and fetal alcohol syndrome.

Scientists predict the areas of the brain to stimulate transitions between different brain states
Using a computer model of the brain, Gustavo Deco, director of the Center for Brain and Cognition, and Josephine Cruzat, a member of his team, together with a group of international collaborators, have developed an innovative method published in Proceedings of the National Academy of Sciences on Sept.

Read More: Brain News and Brain Current Events is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to