Discovery of "KiSS" Gene May Help Stop Spread Of Melanoma

December 04, 1996

HERSHEY, PA -- Researchers at Penn State's College of Medicine in Hershey have discovered a new gene that suppresses the metastasis--or spread--of melanoma, the often fatal skin cancer.

According to a report in the December 4 Journal of the National Cancer Institute, the gene reduces the spread of melanoma in laboratory mice and may help in determining whether human melanomas are prone to metastasis. The gene, called KiSS-1, was isolated from the cells of malignant melanomas by Jeong-Hyung Lee, Ph.D., a postdoctoral pathology fellow from Korea, and Dan R. Welch, Ph.D., assistant professor of pathology, at the College of Medicine's Jake Gittlen Cancer Institute.

Though the KiSS-1 gene does not completely prevent metastasis,"it does keep it from spreading at least 50 percent of the time," says Welch. "KiSS-1 may be the most potent gene to block or suppress metastasis in human cancer." The KiSS-1 gene is located on chromosome 1.

The gene mapping was done by Bernard E. Weissman of the Department of Pathology, Lineberger Cancer Center, University of North Carolina at Chapel Hill, and Jeffrey M. Trent of the Division of Intramural Research, National Center for Human Genome Research, Bethesda, Md.

Melanoma is the fastest growing skin cancer, says Welch. "The rate of increase has more than doubled with each decade since 1950."

The name of the KiSS-1 gene, incidentally, was inspired by the Hershey candy of the same name. The "SS" in KiSS-1 stands for "suppresser sequences," according to Welch, and the rest "simply makes it easily identifiable with Hershey."

*KiSS *


Penn State

Related Melanoma Articles from Brightsurf:

Boosting treatments for metastatic melanoma
University of Cincinnati clinician-scientist Soma Sengupta, MD, PhD, says that new findings from her and Daniel Pomeranz Krummel's, PhD, team might have identified a treatment-boosting drug to enhance effectiveness of therapies for metastatic cancer and make them less toxic, giving patients a fighting chance at survival and improved quality of life.

A promising new tool in the fight against melanoma
An Edith Cowan University (ECU) study has revealed that a key blood marker of cancer could be used to select the most effective treatment for melanoma.

New targets for melanoma treatment
A collaborative study led by Monash University's Biomedicine Discovery Institute and the Olivia Newton-John Cancer Research Institute (ONJCRI) has uncovered new markers (HLA-associated peptides) that are uniquely present on melanoma tumours and could pave the way for therapeutic vaccines to be developed in the fight against melanoma.

Innovative smartphone-camera adaptation images melanoma and non-melanoma
An article published in the Journal of Biomedical Optics (JBO), ''Point-of-care, multispectral, smartphone-based dermascopes for dermal lesion screening and erythema monitoring,'' shows that standard smartphone technology can be adapted to image skin lesions, providing a low-cost, accessible medical diagnostic tool for skin cancer.

Antihistamines may help patients with malignant melanoma
Can a very common allergy medicine improve survival among patients suffering from the serious skin cancer, malignant melanoma?

Blood test for deadly eye melanoma
A simple blood test could soon become the latest monitoring tool for the early detection of melanoma in the eye.

Analysis of melanoma in US by age groups
This study used registry data to determine annual rates of melanoma in pediatric, adolescent, young adult and adult age groups, and the findings suggest an apparent decrease among adolescent and young adults between 2006 and 2015 but increases in older adults.

Vitamin D dials down the aggression in melanoma cells
Vitamin D influences the behaviour of melanoma cells in the lab by making them less aggressive, Cancer Research UK scientists have found.

B cells linked to immunotherapy for melanoma
Immunotherapy uses our body's own immune system to fight cancer.

Five things to know about melanoma
'Five things to know about ... melanoma' in CMAJ (Canadian Medical Association Journal) provides a brief overview of this malignant skin cancer for physicians and patients.

Read More: Melanoma News and Melanoma Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.