Case Western Reserve School of Medicine receives funding for healthy growth research

December 05, 2012

Case Western Reserve University School of Medicine announced that it will receive funding through the Achieving Healthy Growth program within the Grand Challenges in Global Health initiative. This initiative was launched by the Bill & Melinda Gates Foundation to overcome persistent bottlenecks preventing the creation of new and better health solutions for the developing world. Charles H. King, MD, professor of international health and epidemiology and biostatistics, will pursue a research project entitled, "Enhancing Infant Immunity: Effect of Early Maternal Treatment for Parasitic Infections."

"Children in developing countries do not always respond appropriately to life-saving vaccines," King said, "and although several factors may be responsible for this poor vaccination response, chronic parasitic infections appear to play a significant role. We aim to determine how the effects of maternal parasite infections are linked to reduced vaccine efficacy and whether prenatal anti-parasite treatment can reverse this effect."

The goal of the Healthy Growth grant program is to discover the causes of faltering growth during the first 1,000 days of life and to identify effective and affordable interventions to promote healthy growth.

King's project is one of seven grants.

"Safeguarding the health of young children is one of the world's most urgent priorities and a core focus of our work," said Chris Wilson, director of Discovery & Translational Sciences at the Bill & Melinda Gates Foundation. "We hope the suite of grants announced today will give us a deeper understanding of the reasons underlying stunted growth in children in the developing world and how this can be predicted to guide new approaches to improve the health and development of these children."

Parasitic infections are a group of debilitating chronic diseases affecting millions of people worldwide. They greatly impact early childhood development, lead to life-threatening disease and interfere with children's ability to respond to life-saving vaccines. Case Western Reserve's research program will determine how parasitic infections in pregnant mothers affect the developing fetal immune system, how this interference is mediated and whether earlier prenatal parasitic treatment can reverse the trend. These studies are crucial to facilitate current global vaccination programs, future vaccine trials and ongoing parasite treatment and control programs.

The program relies on the considerable resources and expertise at Case Western Reserve, Children's Hospital Oakland Research Institute, and the Division of Vector Borne and Neglected Diseases of the Kenyan Ministry of Public Health and Sanitation. The initiative is based on the group's more than 28 years of collaborative studies in the underserved coast of Kenya, where multiple parasitic infections are endemic.

King is an infectious disease specialist, epidemiologist and senior member of the Center for Global Health and Diseases at Case Western Reserve, and the Schistosomiasis Consortium for Operational Research and Evaluation at the University of Georgia. Since 1984, he has been active on parasite control and immunology research in Kenya, and has recently focused on modeling and implementation of advanced programs for schistosomiasis control and elimination. His current research focuses on identifying human and environmental ecological drivers of vector-borne parasite transmission, and the design of more effective, integrated programs for parasite control.
-end-
About the Grand Challenges

The Bill & Melinda Gates Foundation recognizes that solving our greatest global health and development issues is a long-term effort. Through Grand Challenges, the foundation along with other Grand Challenge partners such as USAID , Grand Challenges Canada, and Brazil's Ministry of Health, are committed to seeking out and rewarding not only established researchers in science and technology, but also young investigators, entrepreneurs and innovators to help expand the pipeline of ideas to fight diseases that claim millions of lives each year.

About Case Western Reserve University School of Medicine

Founded in 1843, Case Western Reserve University School of Medicine is the largest medical research institution in Ohio and is among the nation's top medical schools for research funding from the National Institutes of Health. The School of Medicine is recognized throughout the international medical community for outstanding achievements in teaching. The School's innovative and pioneering Western Reserve2 curriculum interweaves four themes--research and scholarship, clinical mastery, leadership, and civic professionalism--to prepare students for the practice of evidence-based medicine in the rapidly changing health care environment of the 21st century. Nine Nobel Laureates have been affiliated with the School of Medicine.

Annually, the School of Medicine trains more than 800 MD and MD/PhD students and ranks in the top 25 among U.S. research-oriented medical schools as designated by U.S. News & World Report's "Guide to Graduate Education."

The School of Medicine's primary affiliate is University Hospitals Case Medical Center and is additionally affiliated with MetroHealth Medical Center, the Louis Stokes Cleveland Department of Veterans Affairs Medical Center, and the Cleveland Clinic, with which it established the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University in 2002. http://casemed.case.edu

Case Western Reserve University

Related Public Health Articles from Brightsurf:

COVID-19 and the decolonization of Indigenous public health
Indigenous self-determination, leadership and knowledge have helped protect Indigenous communities in Canada during the coronavirus disease 2019 (COVID-19) pandemic, and these principles should be incorporated into public health in future, argue the authors of a commentary in CMAJ (Canadian Medical Association Journal) http://www.cmaj.ca/lookup/doi/10.1503/cmaj.200852.

Public health consequences of policing homelessness
In a new study examining homelessness, researchers find that policy such a lifestyle has massive public health implications, making sleeping on the street even MORE unhealthy.

Electronic health information exchange improves public health disease reporting
Disease tracking is an important area of focus for health departments in the midst of the COVID-19 pandemic.

Pandemic likely to cause long-term health problems, Yale School of Public Health finds
The coronavirus pandemic's life-altering effects are likely to result in lasting physical and mental health consequences for many people--particularly those from vulnerable populations--a new study led by the Yale School of Public Health finds.

The Lancet Public Health: US modelling study estimates impact of school closures for COVID-19 on US health-care workforce and associated mortality
US policymakers considering physical distancing measures to slow the spread of COVID-19 face a difficult trade-off between closing schools to reduce transmission and new cases, and potential health-care worker absenteeism due to additional childcare needs that could ultimately increase mortality from COVID-19, according to new modelling research published in The Lancet Public Health journal.

The Lancet Public Health: Access to identification documents reflecting gender identity may improve trans mental health
Results from a survey of over 20,000 American trans adults suggest that having access to identification documents which reflect their identified gender helps to improve their mental health and may reduce suicidal thoughts, according to a study published in The Lancet Public Health journal.

The Lancet Public Health: Study estimates mental health impact of welfare reform, Universal Credit, in Great Britain
The 2013 Universal Credit welfare reform appears to have led to an increase in the prevalence of psychological distress among unemployed recipients, according to a nationally representative study following more than 52,000 working-age individuals from England, Wales, and Scotland over nine years between 2009-2018, published as part of an issue of The Lancet Public Health journal on income and health.

BU researchers: Pornography is not a 'public health crisis'
Researchers from the Boston University School of Public Health (BUSPH) have written an editorial in the American Journal of Public Health special February issue arguing against the claim that pornography is a public health crisis, and explaining why such a claim actually endangers the health of the public.

The Lancet Public Health: Ageism linked to poorer health in older people in England
Ageism may be linked with poorer health in older people in England, according to an observational study of over 7,500 people aged over 50 published in The Lancet Public Health journal.

Study: Public transportation use linked to better public health
Promoting robust public transportation systems may come with a bonus for public health -- lower obesity rates.

Read More: Public Health News and Public Health Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.