How bacteria get from catheter to patient

December 06, 2010

Patients in hospitals and healthcare facilities can develop infections as a result of contamination of indwelling medical devices such as catheters with bacteria that are normal inhabitants of the skin of the patient or health care personnel. The bacterium Staphylococcus epidermidis is a major cause of such infections. This is in part because of its ability to form biofilms -- surface-attached agglomerations of microorganisms that are extremely difficult to eradicate -- on indwelling devices. Michael Otto and colleagues, at the National Institutes of Health, Bethesda, have now identified the bacterial products that enable Staphylococcus epidermidis biofilms to detach from the surface to which they are adhered and cause infection in a mouse model of catheterization. Importantly, molecules known as antibodies that target these bacterial products inhibited bacterial spread in the mouse model, leading the authors to suggest that interfering with biofilm detachment mechanisms might provide a new approach to preventing biofilm-associated infections.
-end-
TITLE: Staphylococcus epidermidis surfactant peptides promote biofilm maturation and dissemination of biofilm-associated infection in mice

AUTHOR CONTACT:
Michael Otto
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Phone: 301.443.5209; Fax: 301.480.3633; E-mail: motto@niaid.nih.gov.

View this article at: http://www.jci.org/articles/view/42520?key=109e2fdc23f5ff35648c

JCI Journals

Related Bacteria Articles from Brightsurf:

Siblings can also differ from one another in bacteria
A research team from the University of Tübingen and the German Center for Infection Research (DZIF) is investigating how pathogens influence the immune response of their host with genetic variation.

How bacteria fertilize soya
Soya and clover have their very own fertiliser factories in their roots, where bacteria manufacture ammonium, which is crucial for plant growth.

Bacteria might help other bacteria to tolerate antibiotics better
A new paper by the Dynamical Systems Biology lab at UPF shows that the response by bacteria to antibiotics may depend on other species of bacteria they live with, in such a way that some bacteria may make others more tolerant to antibiotics.

Two-faced bacteria
The gut microbiome, which is a collection of numerous beneficial bacteria species, is key to our overall well-being and good health.

Microcensus in bacteria
Bacillus subtilis can determine proportions of different groups within a mixed population.

Right beneath the skin we all have the same bacteria
In the dermis skin layer, the same bacteria are found across age and gender.

Bacteria must be 'stressed out' to divide
Bacterial cell division is controlled by both enzymatic activity and mechanical forces, which work together to control its timing and location, a new study from EPFL finds.

How bees live with bacteria
More than 90 percent of all bee species are not organized in colonies, but fight their way through life alone.

The bacteria building your baby
Australian researchers have laid to rest a longstanding controversy: is the womb sterile?

Hopping bacteria
Scientists have long known that key models of bacterial movement in real-world conditions are flawed.

Read More: Bacteria News and Bacteria Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.