Cedars-Sinai wins $7.3M grant to further study heart stem cell therapy safety, effectiveness

December 06, 2016

LOS ANGELES (Dec. 6, 2016) - Researchers from the Cedars-Sinai Heart Institute and the Cedars-Sinai Department of Medicine are expanding their ongoing evaluation of a novel cell-based therapeutic candidate into the area of pulmonary arterial hypertension (PAH). This work will be supported by a recently-awarded $7.3 million grant from the California Institute for Regenerative Medicine.

Pulmonary arterial hypertension is a chronic disease that is very different from, and much more dangerous than, regular hypertension. Caused by high blood pressure in the large arteries leading from the heart to the lungs, the condition affects 200,000 patients in the U.S. every year and can lead to heart failure and premature death. Symptoms include shortness of breath, dizziness and chest pain.

The new clinical study will test the safety and effectiveness of treating PAH with cells known as cardiosphere-derived cells (CDCs). CDCs consist of a single type of cardiac progenitor cell, and are currently being studied in clinical trials at Cedars-Sinai for other types of heart disease and for Duchenne muscular dystrophy. The CDCs to be used in the upcoming study are manufactured by Capricor Therapeutics, Inc. (NASDAQ: CAPR), which is developing this technology as its therapeutic product candidate CAP-1002.

"We have an exciting opportunity to try something new in these patients who currently have limited treatment options," said Eduardo Marbán, MD, PhD, director of the Cedars-Sinai Heart Institute and the researcher who invented and developed the CDC technology. "Our theory is that introducing these cells into the arteries leading to the lungs will reduce inflammation and, as a result, prevent permanent damage to the heart by decreasing pulmonary blood pressure."

The clinical study in PAH will be led by Michael I. Lewis, MD, director of Respiratory Therapy at Cedars-Sinai, and could begin enrolling patients as early as mid-2017.

In 2009, a team led by Marbán completed the world's first clinical trial of CDCs. The results, which were published in The Lancet in 2012, showed a medical first: evidence that healthy heart muscle could be therapeutically regenerated in a heart damaged by a heart attack. Since then, Marbán's research has led to several clinical trials in which heart disease patients undergo a catheter-based procedure during which they receive an infusion of millions of CDCs.

"The primary goal of our study in pulmonary arterial hypertension is to verify safety," Lewis said. "However, we did see significant improvement in laboratory animal tests that we hope will lead us to innovative and effective treatments for a group of patients who currently face an uphill battle."

"This award is a reflection of the continued excellence of our heart institute in leading the field and maintaining Cedars-Sinai as a pioneer in successfully and safely bringing cellular therapies to treat our patients with serious cardiovascular disorders," said Shlomo Melmed, MD, Cedars-Sinai executive vice president for Academic Affairs, dean of the medical faculty and the Helene A. and Philip E. Hixon Distinguished Chair in Investigative Medicine.

It is the second time in 2016 that Marbán's research resulted in a major grant to fund a clinical trial for patients with an incurable condition. Earlier this year, the Department of Defense awarded Cedars-Sinai a $10 million grant to fund a cell therapy trial for patients diagnosed with a common but difficult-to-treat form of heart failure called heart failure with preserved ejection fraction.

The process to grow CDCs was developed by Marbán when he was on the faculty of Johns Hopkins University and further developed at Cedars-Sinai. Capricor has licensed the process from Johns Hopkins and from Cedars-Sinai for clinical and commercial development. Capricor has licensed additional intellectual property from Cedars-Sinai and the University of Rome. Cedars-Sinai and Marbán have financial interests in Capricor.
-end-
About the Cedars-Sinai Heart Institute

The Cedars-Sinai Heart Institute is internationally recognized for outstanding heart care built on decades of innovation and leading edge research. From cardiac imaging and advanced diagnostics to surgical repair of complex heart problems to the training of the heart specialists of tomorrow and research that is deepening medical knowledge and practice, the Cedars-Sinai Heart Institute is known around the world for excellence and innovations.

Cedars-Sinai Medical Center

Related Heart Disease Articles from Brightsurf:

Cellular pathway of genetic heart disease similar to neurodegenerative disease
Research on a genetic heart disease has uncovered a new and unexpected mechanism for heart failure.

Mechanism linking gum disease to heart disease, other inflammatory conditions discovered
The link between periodontal (gum) disease and other inflammatory conditions such as heart disease and diabetes has long been established, but the mechanism behind that association has, until now, remained a mystery.

New 'atlas' of human heart cells first step toward precision treatments for heart disease
Scientists have for the first time documented all of the different cell types and genes expressed in the healthy human heart, in research published in the journal Nature.

With a heavy heart: How men and women develop heart disease differently
A new study by researchers from McGill University has uncovered that minerals causing aortic heart valve blockage in men and women are different, a discovery that could change how heart disease is diagnosed and treated.

Heart-healthy diets are naturally low in dietary cholesterol and can help to reduce the risk of heart disease and stroke
Eating a heart-healthy dietary pattern rich in vegetables, fruits, whole grains, low-fat dairy products, poultry, fish, legumes, vegetable oils and nuts, which is also limits salt, red and processed meats, refined-carbohydrates and added sugars, is relatively low in dietary cholesterol and supports healthy levels of artery-clogging LDL cholesterol.

Pacemakers can improve heart function in patients with chemotherapy-induced heart disease
Research has shown that treating chemotherapy-induced cardiomyopathy with commercially available cardiac resynchronization therapy (CRT) delivered through a surgically implanted defibrillator or pacemaker can significantly improve patient outcomes.

Arsenic in drinking water may change heart structure raising risk of heart disease
Drinking water that is contaminated with arsenic may lead to thickening of the heart's main pumping chamber in young adults, according to a new study by researchers at Columbia University Mailman School of Public Health.

New health calculator can help predict heart disease risk, estimate heart age
A new online health calculator can help people determine their risk of heart disease, as well as their heart age, accounting for sociodemographic factors such as ethnicity, sense of belonging and education, as well as health status and lifestyle behaviors.

Wide variation in rate of death between VA hospitals for patients with heart disease, heart failure
Death rates for veterans with ischemic heart disease and chronic heart failure varied widely across the Veterans Affairs (VA) health care system from 2010 to 2014, which could suggest differences in the quality of cardiovascular health care provided by VA medical centers.

Heart failure: The Alzheimer's disease of the heart?
Similar to how protein clumps build up in the brain in people with some neurodegenerative diseases such as Alzheimer's and Parkinson's diseases, protein clumps appear to accumulate in the diseased hearts of mice and people with heart failure, according to a team led by Johns Hopkins University researchers.

Read More: Heart Disease News and Heart Disease Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.