New drug may help cancer patients in need of stem cell transplants, Jefferson trial shows

December 07, 2003

A new drug may help patients restore their blood-forming system after high-dose chemotherapy, according to results from a clinical trial at the Kimmel Cancer Center at Thomas Jefferson University Hospital in Philadelphia.

In the phase II trial, which is being conducted at several centers in the United States, researchers are attempting to determine if patients with multiple myeloma or non-Hodgkin's lymphoma who receive the drug AMD-3100 along with the standard drug G-CSF have more stem cells available for transplantation as compared to those who receive only G-CSF.

AMD-3100 blocks a specific cellular receptor, triggering the movement of stem cells out of the bone marrow and into the circulating blood, boosting the supply of stem cells from the bone marrow to be used in transplantation. Stem cell transplantation entails collecting certain types of cells known as hematopoietic stem cells from patients who receive treatment with high-dose radiation and/or chemotherapy for cancers such as leukemias, lymphomas and multiple myeloma, all of which involve the blood and immune system. The cells, once returned to the body, help restore the blood-forming system within the bone marrow - and the body's immune system, which is severely damaged if not destroyed by high-dose chemotherapy and/or radiation.

To date, every one of 19 patients given the drug combination were able to mobilize stem cells from the marrow to the bloodstream better than those who had G-CSF alone, says Neal Flomenberg, M.D., professor of medicine and director of medical oncology at Jefferson Medical College of Thomas Jefferson University, who oversees the trial at Jefferson. Dr. Flomenberg presents the trial's interim results December 7 at the American Society of Hematology's 45th Annual Meeting and Exposition in San Diego.

As a result, he says, there were fewer stem cell collections necessary and more stem cells retrieved. "This is the first time the drug combination has been tested in patients who have undergone chemotherapy, whose marrows have already been somewhat beaten up from prior treatment," Dr. Flomenberg says. "This is the acid test. These are the first patients whose cell products are being used for transplants."

Most patients undergo standard chemotherapy for four to eight months before they have a stem cell transplant, he explains. Some patients won't have a transplant until their disease relapses and treatment once again puts them back in remission. These treatments sometimes make subsequent stem cell collection difficult.

According to Dr. Flomenberg, stem cell transplantation is "front line therapy for multiple myeloma, or cancer of the bone marrow, and for high-risk lymphoma patients."

Approximately 25 percent to 35 percent of transplant patients have trouble moving stem cells from their bone marrow into the bloodstream using the standard drug, G-CSF. "Some patients with the standard approach don't mobilize well, meaning more collections and often a poor or unusable cell product," he says.

Dr. Flomenberg explains that based on results to date, the drug holds promise to cut down the number of stem cell collections patients need. The drug combination may both increase the number and improve the quality of cells collected. The greater the number of available stem cells, the more likely transplantation will be successful. In some cases, this can mean the difference between a patient being able to receive a transplant or not. The drug has little toxicity.

"I have a lot of hope that this drug will become a standard," he says.

The trial will enroll up to 24 cancer patients with either multiple myeloma or non-Hodgkin's lymphoma.

Other trial sites include Washington University in St. Louis, the University of Rochester, Virginia Commonwealth University in Richmond, Hackensack University Medical Center in Hackensack, N.J., and the Medical College of Wisconsin in Milwaukee.
The study is sponsored by AnorMED, Inc., a Vancouver, British Columbia-based drug development company. AnorMED's efforts are aimed at the discovery and development of small molecule therapeutics to treat diseases including HIV, rheumatoid arthritis, asthma and cancer.

For more information about the trial, please call 1-800-JEFF-NOW.

Steve Benowitz or Phyllis Fisher
After Hours: 215-955-6060

Thomas Jefferson University

Related Stem Cells Articles from Brightsurf:

SUTD researchers create heart cells from stem cells using 3D printing
SUTD researchers 3D printed a micro-scaled physical device to demonstrate a new level of control in the directed differentiation of stem cells, enhancing the production of cardiomyocytes.

More selective elimination of leukemia stem cells and blood stem cells
Hematopoietic stem cells from a healthy donor can help patients suffering from acute leukemia.

Computer simulations visualize how DNA is recognized to convert cells into stem cells
Researchers of the Hubrecht Institute (KNAW - The Netherlands) and the Max Planck Institute in Münster (Germany) have revealed how an essential protein helps to activate genomic DNA during the conversion of regular adult human cells into stem cells.

First events in stem cells becoming specialized cells needed for organ development
Cell biologists at the University of Toronto shed light on the very first step stem cells go through to turn into the specialized cells that make up organs.

Surprising research result: All immature cells can develop into stem cells
New sensational study conducted at the University of Copenhagen disproves traditional knowledge of stem cell development.

The development of brain stem cells into new nerve cells and why this can lead to cancer
Stem cells are true Jacks-of-all-trades of our bodies, as they can turn into the many different cell types of all organs.

Healthy blood stem cells have as many DNA mutations as leukemic cells
Researchers from the Princess Máxima Center for Pediatric Oncology have shown that the number of mutations in healthy and leukemic blood stem cells does not differ.

New method grows brain cells from stem cells quickly and efficiently
Researchers at Lund University in Sweden have developed a faster method to generate functional brain cells, called astrocytes, from embryonic stem cells.

NUS researchers confine mature cells to turn them into stem cells
Recent research led by Professor G.V. Shivashankar of the Mechanobiology Institute at the National University of Singapore and the FIRC Institute of Molecular Oncology in Italy, has revealed that mature cells can be reprogrammed into re-deployable stem cells without direct genetic modification -- by confining them to a defined geometric space for an extended period of time.

Researchers develop a new method for turning skin cells into pluripotent stem cells
Researchers at the University of Helsinki, Finland, and Karolinska Institutet, Sweden, have for the first time succeeded in converting human skin cells into pluripotent stem cells by activating the cell's own genes.

Read More: Stem Cells News and Stem Cells Current Events is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to