News tips from the Journal of Neuroscience

December 07, 2004

1. Wake-Sleep Cycling in the Rat

Damien Gervasoni, Shih-Chieh Lin, Sidarta Ribeiro, Ernesto S. Soares, Janaina Pantoja, and Miguel A. L. Nicolelis

Just as behavior differs greatly between waking and sleep states, so too does electrical brain activity, from the fast oscillating pattern of wakefulness to the slower waves of sleep states and then back to the fast activity associated with rapid eye movement (REM) sleep. This week, Gervasoni et al. examine the dynamics of the wake-sleep cycle.

2. Insulin, IDE, and Beta-Amyloid

Lixia Zhao, Bruce Teter, Takashi Morihara, Giselle P. Lim, Surendra S. Ambegaokar, Oliver J. Ubeda, Sally A. Frautschy, and Greg M. Cole

Insulin-degrading enzyme (IDE), despite its name, can also degrade Beta-amyloid (Aβ) peptide that accumulates in Alzheimer's disease (AD). There are some tantalizing clues linking IDE and AD. This week Zhao et al. examine several aspects of this idea.

Society for Neuroscience

Related Insulin Articles from Brightsurf:

US Insulin prices 8 times higher than in other nations
Insulin list prices in the United States have increased dramatically over the past decade, with per person insulin spending doubling between 2012 and 2016.

A gatekeeper against insulin resistance in the brain
The brain plays a major role in controlling our blood glucose levels.

Sorting and secreting insulin by expiration date
Visualizing the age of insulin secreting granules in cells allowed researchers to investigate how cells' preference for secreting newer granules is disrupted in diabetes.

Researchers develop a new ultrafast insulin
Stanford researchers tested a new insulin drug in diabetic pigs and found that it was twice as fast-acting as traditional insulin.

Insulin signaling suppressed by decoys
The discovery of an insulin 'decoy' molecule from the lab of Matthew Gill, PhD, in Florida shakes up understanding of insulin signaling, with implications for diabetes, longevity and aging research.

New mechanism for dysfunctional insulin release identified
In a new study, researchers at Uppsala University have identified a previously unknown mechanism that regulates release of insulin, a hormone that lowers blood glucose levels, from the β-cells (beta cells) of the pancreas.

Type 2 diabetes is not just about insulin
Obesity, by promoting the resistance to the action of insulin, is a major risk factor of diabetes.

The insulin under the influence of light
By understanding how the brain links the effects of insulin to light, researchers (UNIGE) are deciphering how insulin sensitivity fluctuates according to circadian cycles.

Does insulin resistance cause fibromyalgia?
Researchers led by a team from The University of Texas Medical Branch at Galveston were able to dramatically reduce the pain of fibromyalgia patients with medication that targeted insulin resistance.

Insulin insights
Insulin triggers genome-wide changes in gene expression via an unexpected mechanism.

Read More: Insulin News and Insulin Current Events is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to