Nav: Home

Paternal aging and its possible link to neurodevelopmental disorders

December 08, 2016

Neurodevelopmental disorders such as autism spectrum disorder (ASD) and attention deficit and hyperactivity disorder (ADHD) are on the rise but its underlying mechanisms are poorly understood.

Noriko Osumi, Kaichi Yoshizaki and colleagues at Tohoku University's Graduate School of Medicine collaborated with Shigeru Wakana and Tamio Furuse at RIKEN Bio-Resource Center, and Tucci Valter at Istituto Italiano di Tecnologia, to conduct comprehensive behavioral analyses on how paternal aging influences the behavior of offspring that inherit a genetic risk (a mutation in Pax6 gene*).

In the experiments, in order to minimize the physical influence of the father, the male mouse was isolated and in vitro fertilization was used to impregnate the female. The researchers found that the offspring of young fathers exhibited impaired vocal communication, while the offspring of older fathers exhibited hyperlocomotion.

The results are significant for both animal researchers and the public. For researchers working on animal models, it shows that the age of male mice can influence the behavior of the offspring, so this should be a consideration when they are used to mate.

For the public, the research shows that paternal aging may exacerbate genetic risks - this could explain why there is a rapid rise in the ratio of children with ASD or ADHD, due to men having children later in life.
-end-
This paper was published online in PLoS ONE on November 17. The research was supported in part by KAKENHI (25640002 to K.Y. and 16H06530 to N.O.) from the Ministry of Education, Culture, Sports, Science and Technology of Japan.

*Pax6 gene encodes a transcription factor that regulates expression of many downstream genes and is known to be related to ASD.

Tohoku University

Related Adhd Articles:

ADHD medication: How much is too much for a hyperactive child?
When children with ADHD don't respond well to Methylphenidate (MPH, also known as Ritalin) doctors often increase the dose.
Antipsychotic use in youths with ADHD is low, but still cause for concern
A new study eased fears about the proportion of youths with ADHD taking antipsychotic drugs, but still found that many prescriptions may be inappropriate.
How stimulant treatment prevents serious outcomes of ADHD
Analysis quantifies the extent which stimulant treatment reduces serious outcomes in children and young adults with ADHD.
Did Leonardo da Vinci have ADHD?
Leonardo da Vinci produced some of the world's most iconic art, but historical accounts show that he struggled to complete his works.
More sleep may help teens with ADHD focus and organize
Teenagers with attention deficit hyperactivity disorder (ADHD) may benefit from more sleep to help them focus, plan and control their emotions.
More Adhd News and Adhd Current Events

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Erasing The Stigma
Many of us either cope with mental illness or know someone who does. But we still have a hard time talking about it. This hour, TED speakers explore ways to push past — and even erase — the stigma. Guests include musician and comedian Jordan Raskopoulos, neuroscientist and psychiatrist Thomas Insel, psychiatrist Dixon Chibanda, anxiety and depression researcher Olivia Remes, and entrepreneur Sangu Delle.
Now Playing: Science for the People

#537 Science Journalism, Hold the Hype
Everyone's seen a piece of science getting over-exaggerated in the media. Most people would be quick to blame journalists and big media for getting in wrong. In many cases, you'd be right. But there's other sources of hype in science journalism. and one of them can be found in the humble, and little-known press release. We're talking with Chris Chambers about doing science about science journalism, and where the hype creeps in. Related links: The association between exaggeration in health related science news and academic press releases: retrospective observational study Claims of causality in health news: a randomised trial This...