New dynamic PET technique offers greater comfort for cancer patients

December 09, 2003

Reston, VA - In addition to giving the best possible physical care, medical professionals are concerned about fostering the emotional well being of individuals undergoing diagnosis or treatment for cancer. Combining these goals is a challenge German researchers undertook when they conducted a study to determine if dynamic PET provides useful data when taken over a shorter period than the traditional one-hour scan. The study revealed the shorter scan can provide an accurate diagnosis, not only decreasing false positive results (when tumors in cancer-free patients are misdiagnosed as cancerous) and predicting patient response to chemotherapy, but also providing for a more comfortable diagnostic experience.

In many PET diagnoses, nuclear medicine professionals use a simple visual evaluation to detect tumors. While this method is generally quite accurate, PET scans can have the tendency to result in false positives when tissue that is merely infected appears visually similar to a malignant tumor. Static PET scans allow doctors to assess standardized uptake value (SUV), which does provide some quantifiable data to differentiate between benign and malignant growths, but a dynamic PET scan can provide additional data about the rate of uptake and the movement of 18F-FDG through the body and tumor(s). This data, when analyzed mathematically, provides a more complete diagnosis.

Results of the German study, which was published in the December 2003 issue of The Journal of Nuclear Medicine, revealed that a 10-minute dynamic scan immediately after tracer injection coupled with a static scan 56-60 minutes after injection provided statistically accurate information about 18F-FDG influx, VB (vascular fraction), k1 and SUV. A comprehensive analysis of 151 data sets from patients with a variety of cancers allowed researchers to make this conclusion.

"Our goal was to delineate a procedure that provides more information than a static scan while also employing wise use of resources," the researchers stated. "Less time spent in the PET scanner is more comfortable for patients, and, from the perspective of the nuclear medicine practitioner, this procedure could also save both time and money."
"Shortened PET Data Acquisition Protocol for the Quantification of 18F-FDG Kinetics" was written by Ludwig G. Strauss, MD, Antonia Dimitrakopoulou-Strauss, MD and Uwe Haberkorn, MD from Medical PET Group, Biological Imaging, Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center in Heidelberg, Germany.

Copies of the article and images related to the study are available to media upon request to Kimberly A. Bennett. Print copies can be obtained at $15 per copy by contacting the SNM Service Center, Society of Nuclear Medicine, 1850 Samuel Morse Drive, Reston, VA 20190-5315; phone: 703-326-1186; fax: 703-708-9015; email: A yearly subscription to the journal is $210 for individuals and $318 for institutions. A subscription is a Society of Nuclear Medicine member benefit.

The Society of Nuclear Medicine is an international scientific and professional organization of more than 14,000 members dedicated to promoting the science, technology, and practical applications of nuclear medicine. The SNM is based in Reston, VA.

Society of Nuclear Medicine

Related Cancer Articles from Brightsurf:

New blood cancer treatment works by selectively interfering with cancer cell signalling
University of Alberta scientists have identified the mechanism of action behind a new type of precision cancer drug for blood cancers that is set for human trials, according to research published in Nature Communications.

UCI researchers uncover cancer cell vulnerabilities; may lead to better cancer therapies
A new University of California, Irvine-led study reveals a protein responsible for genetic changes resulting in a variety of cancers, may also be the key to more effective, targeted cancer therapy.

Breast cancer treatment costs highest among young women with metastic cancer
In a fight for their lives, young women, age 18-44, spend double the amount of older women to survive metastatic breast cancer, according to a large statewide study by the University of North Carolina at Chapel Hill.

Cancer mortality continues steady decline, driven by progress against lung cancer
The cancer death rate declined by 29% from 1991 to 2017, including a 2.2% drop from 2016 to 2017, the largest single-year drop in cancer mortality ever reported.

Stress in cervical cancer patients associated with higher risk of cancer-specific mortality
Psychological stress was associated with a higher risk of cancer-specific mortality in women diagnosed with cervical cancer.

Cancer-sniffing dogs 97% accurate in identifying lung cancer, according to study in JAOA
The next step will be to further fractionate the samples based on chemical and physical properties, presenting them back to the dogs until the specific biomarkers for each cancer are identified.

Moffitt Cancer Center researchers identify one way T cell function may fail in cancer
Moffitt Cancer Center researchers have discovered a mechanism by which one type of immune cell, CD8+ T cells, can become dysfunctional, impeding its ability to seek and kill cancer cells.

More cancer survivors, fewer cancer specialists point to challenge in meeting care needs
An aging population, a growing number of cancer survivors, and a projected shortage of cancer care providers will result in a challenge in delivering the care for cancer survivors in the United States if systemic changes are not made.

New cancer vaccine platform a potential tool for efficacious targeted cancer therapy
Researchers at the University of Helsinki have discovered a solution in the form of a cancer vaccine platform for improving the efficacy of oncolytic viruses used in cancer treatment.

American Cancer Society outlines blueprint for cancer control in the 21st century
The American Cancer Society is outlining its vision for cancer control in the decades ahead in a series of articles that forms the basis of a national cancer control plan.

Read More: Cancer News and Cancer Current Events is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to