Medical College of Wisconsin researchers

December 09, 2005

Researchers at the Medical College of Wisconsin in Milwaukee in collaboration with a national team have developed a biodefense cocktail which activates the immune system against a broad range of viruses and bacteria. The new treatment boosts the body's response against common characteristics of germs. It is expected to be deployed to our troops within the next five years. Using a nasal spray, the cocktail of drugs will trigger immune activation in the respiratory and gastrointestinal tracts, the most likely routes of attack.

The study is published in the current issue of Journal of Allergy & Clinical Immunology (Volume 116, Issue 6, Pgs. 1334-1342-December 2005). Catherine Amlie-Lefond, M.D, assistant professor of neurology, is the first author, and Harry T. Whelan, M.D., professor of neurology, is the senior author.

According to Dr. Whelan, "This will revolutionize our defense against germ warfare, as well as the treatment of infectious diseases in our population, as a whole. It is possible to include agents which inhibit molecular events leading to septic shock, as well. This new technology confers broad spectrum, short term, immunity against unknown biothreat agents for war fighters sent into harm's way."
-end-
Dr Whelan who is a captain in the Navy is Research Advisor, Future Plans & Strategy, to Deputy Chief, Bureau of Medicine and Surgery, REDCOM MW Medical Staff Diving Medical Officer, and holds the Bleser Endowed Professorship through the Children's Hospital of Wisconsin Foundation.

Medical College of Wisconsin

Related Immune System Articles from Brightsurf:

How the immune system remembers viruses
For a person to acquire immunity to a disease, T cells must develop into memory cells after contact with the pathogen.

How does the immune system develop in the first days of life?
Researchers highlight the anti-inflammatory response taking place after birth and designed to shield the newborn from infection.

Memory training for the immune system
The immune system will memorize the pathogen after an infection and can therefore react promptly after reinfection with the same pathogen.

Immune system may have another job -- combatting depression
An inflammatory autoimmune response within the central nervous system similar to one linked to neurodegenerative diseases such as multiple sclerosis (MS) has also been found in the spinal fluid of healthy people, according to a new Yale-led study comparing immune system cells in the spinal fluid of MS patients and healthy subjects.

COVID-19: Immune system derails
Contrary to what has been generally assumed so far, a severe course of COVID-19 does not solely result in a strong immune reaction - rather, the immune response is caught in a continuous loop of activation and inhibition.

Immune cell steroids help tumours suppress the immune system, offering new drug targets
Tumours found to evade the immune system by telling immune cells to produce immunosuppressive steroids.

Immune system -- Knocked off balance
Instead of protecting us, the immune system can sometimes go awry, as in the case of autoimmune diseases and allergies.

Too much salt weakens the immune system
A high-salt diet is not only bad for one's blood pressure, but also for the immune system.

Parkinson's and the immune system
Mutations in the Parkin gene are a common cause of hereditary forms of Parkinson's disease.

How an immune system regulator shifts the balance of immune cells
Researchers have provided new insight on the role of cyclic AMP (cAMP) in regulating the immune response.

Read More: Immune System News and Immune System Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.