Toward a fast, accurate urine test for pneumonia

December 09, 2009

Scientists are reporting a discovery of the potential basis for a urine test to diagnose community-acquired pneumonia (CAP), a difficult-to-diagnose disease that is the sixth leading cause of death in the United States. The test could save lives by allowing doctors to begin the right treatment earlier than often occurs at present. The study appears online in ACS' Journal of Proteome Research.

In the new study, Carolyn Slupsky points out that a variety of bacteria, viruses, and other microbes can cause pneumonia. Streptococcus pneumoniae (S. pneumoniae) is among the germs that cause CAP. These microbes can be difficult to detect using conventional blood tests, resulting in too-often delaying the start of the right antibiotic to best treat the disease.

The scientists measured metabolites in the urine of patients with pneumonia caused by S. pneumoniae and compared these metabolite profiles to those of urine samples from patients with other types of lung diseases, as well as pneumonia caused by a variety of other microbes. They found that infection with S. pneumoniae produces a distinct pattern of metabolites in much the same way that that the distinct whorls and curves in fingerprints can identify individuals. Identification of this pattern paves the way for more rapid diagnosis so that patients can start treatment sooner with the right medication, they say.
"Pneumococcal Pneumonia: Potential for Diagnosis through a Urinary Metabolic Profile"


Carolyn Slupsky, Ph.D.
Departments of Nutrition and Food Science & Technology
University of California-Davis
Davis, Calif. 95616
Phone: 530-719-5757
Fax: 530-752-8966

American Chemical Society

Related Pneumonia Articles from Brightsurf:

Vaccine proves effective against the most severe type of pneumonia
A pneumococcal vaccine was effective at protecting children in Laos against the most severe type of pneumonia, a new study has found.

Osteoporosis treatment may also protect against pneumonia
A recent study published in the Journal of Bone and Mineral Research found that nitrogen-containing bisphosphonates (N-BPs) such as alendronate, which are widely used to treat postmenopausal osteoporosis, are linked with lower risks of pneumonia and of dying from pneumonia.

Elderly patients with pneumonia twice as likely to die as those with broken hips, yet underestimate the danger of pneumonia
Elderly patients who are hospitalised with pneumonia are twice as likely to die as those hospitalised with hip fractures -- yet many elderly people fail to accurately assess their risk of pneumonia, concludes research due to be presented at the European Congress of Clinical Microbiology and Infectious Diseases (ECCMID).

Pneumonia recovery reprograms immune cells of the lung
Researchers have determined that after lungs recover from infection, alveolar macrophages (immune cells that live in the lungs and help protect the lungs against infection) are different in multiple ways and those differences persist indefinitely.

Skin and mucous membrane lesions as complication of pneumonia
Painful inflammatory lesions of the skin and mucous membranes may occur in children who develop bacterial pneumonia.

Vaccine reduces likelihood of severe pneumonia
A new study has found severe pneumonia decreases by 35 per cent in children who receive a vaccine against a pneumonia-causing bacteria.

Bacteria in pneumonia attack using bleaching agent
Research shows that bacteria use hydrogen peroxide to weaken the immune system and cause pneumonia.

Many kids with pneumonia get unnecessary antibiotics, chest X-rays
Preschool children with community-acquired pneumonia often receive unnecessary tests and treatment at outpatient clinics and emergency departments, according to a nationally representative study led by Todd Florin, M.D., MSCE, from Ann & Robert H.

Certain psychiatric drugs linked with elevated pneumonia risk
A review of published studies indicates that use of benzodiazepines and benzodiazepine related drugs (BZRDs), which are prescribed to treat various psychiatric diseases, may increase the risk of pneumonia.

Bacterial pneumonia far more dangerous to the heart than viral pneumonia, study finds
Heart complications in patients diagnosed with bacterial pneumonia are more serious than in patients diagnosed with viral pneumonia, according to new research.

Read More: Pneumonia News and Pneumonia Current Events is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to