Young people with autism show cognitive gains from childhood to early adult life

December 09, 2020

Washington, DC, December 9, 2020 - Individuals diagnosed with autism spectrum disorder (ASD) face a lifelong challenge characterized by qualitative impairments in both communication and social interaction. However a new study appearing in the Journal of the American Academy of Child and Adolescent Psychiatry (JAACAP), published by Elsevier, reports that in a cohort of 126 individuals with ASD, IQ increased on average 7.48 points from ages 12 to 23 years old. The study showed that IQ increases were greatest among those participants who had experienced early regression in language skills and had greater communication problems at age 12. Individuals with ASD with a history of regression had an IQ increase of 15.4 points compared to 6.6 points in those not reporting early regression.

In contrast to the IQ improvement, parent-reported overall trajectories of autistic traits, while variable, did not change over the same time period on average. Attending mainstream education, as compared to a specialist placement, was linked to relative improvement in autistic symptoms -- a finding that remained after accounting for possible confounders.

"We followed up this unique population-based cohort of autistic children to better understand their outcomes in early adulthood," said lead investigator Emily Simonoff, Professor of Child and Adolescent Psychiatry, King's College London. "So much of our current understanding of how autistic children fare in adult life is based on clinical cohorts that often includes the most severe end of the spectrum."

Based on the UK Special Needs and Autism Project (SNAP) cohort, a population-based cohort first studied in the year 2000 to estimate autism prevalence, the sample was originally drawn from a population of over 56,000 children aged 9-10 years of age living in South-east England. The sample also included those with special educational needs for any reason or having received a clinical diagnosis of autism. A total of 158 children seen at age 12 years received an autism research diagnosis and have been followed up at ages 16 and 23 years respectively. IQ and autistic traits are amongst the most important predictors of independent functioning in adult life for autistic people.

A strength of the study is the use of the same measures at each timepoint, making comparisons easier to interpret. The statistical approach (latent growth curve modelling) identifies factors that influence overall level of IQ/autistic traits, as well as the factors that predict change compared to the rest of the cohort. The cohort includes participants from the full IQ range seen in autistic people, from severely intellectually disabled (IQ < 20) to the superior range (> 120). Because IQ is standardized for every age, it is not expected to change over time. The mean increase of 7.48 is a substantial increase and would be noticeable by parents and teachers.

"While we can't exclude the improvement is partly due to increased motivation or ability to access IQ tests, rather than an intrinsic improvement in learning ability, these alternatives are also important aspects of real-life functioning that may open new educational and employment opportunities for autistic people," Dr. Simonoff added. Lower level of language and greater severity of autism at 12 years predicted the overall level of IQ (but not relative change).

This is the first study to show that early language regression affects IQ trajectory. An earlier report from this cohort showed that those with regression had more advanced early cognitive development than the rest of the cohort; one possible explanation to be pursued is the idea that regression is an observable marker of a perturbation in developmental course and this subgroup continue to revert to their underlying cognitive trajectory.

Autistic symptoms from earlier childhood and mental health problems predict the overall level of autistic traits from late childhood to adulthood. The present finding that more mainstream education as compared to specialist provision for autism and/or intellectual disability predicts fewer autistic symptoms has potentially important policy implications.

"Our statistical approach attempts to account for possible confounders, children were not randomly assigned to school type and we can't fully exclude that unmeasured characteristics are driving this result. Nevertheless, it suggests social benefits of inclusive education for autistic pupils," concluded Dr. Simonoff.

As not all pupils can access mainstream education, identifying the most important active ingredients to dd to specialist educational provision could improve autistic outcomes more widely.
-end-
Notes for editors

The article is "Trajectories in Symptoms of Autism and Cognitive Ability in Autism From Childhood to Adult Life: Findings From a Longitudinal Epidemiological Cohort," by Emily Simonoff, MD, Rachel Kent, PhD, Dominic Stringer, MSc, Catherine Lord, PhD, Jackie Briskman, BSc, Steve Lukito, PhD, Andrew Pickles, PhD, Tony Charman, PhD, Gillian Baird, FRCPCH (https://doi.org/10.1016/j.jaac.2019.11.020). It appears in the Journal of the American Academy of Child and Adolescent Psychiatry, volume 59, issue 12 (December 2020), published by Elsevier.

Copies of this paper are available to credentialed journalists upon request; please contact the JAACAP Editorial Office at support@jaacap.org">support@jaacap.org or +1 202 587 9674.

Dr. Simonoff is Professor of Child and Adolescent Psychiatry, Head of Department at King's College London, Institute of Psychiatry, Psychology and Neuroscience, and Academic Lead for the Child and Adolescent Mental Health Services Clinical Academic Group at the South London and Maudsley Foundation Trust. Her clinical and research work focusses on children with autism and related neurodevelopmental conditions and leads the UK autism cohorts SNAP and QIEST. Dr. Simonoff is a UK National Institute of Health Research Senior Investigator and Senior Clinical Advisor to the National Institute of Health and Clinical Excellence (NICE). She is also Chair of the European ADHD Guidelines Group.

About JAACAP

Journal of the American Academy of Child and Adolescent Psychiatry (JAACAP) is the official publication of the American Academy of Child and Adolescent Psychiatry. JAACAP is the leading journal focusing exclusively on today's psychiatric research and treatment of the child and adolescent. Published twelve times per year, each issue is committed to its mission of advancing the science of pediatric mental health and promoting the care of youth and their families.

The Journal's purpose is to advance research, clinical practice, and theory in child and adolescent psychiatry. It is interested in manuscripts from diverse viewpoints, including genetic, epidemiological, neurobiological, cognitive, behavioral, psychodynamic, social, cultural, and economic. Studies of diagnostic reliability and validity, psychotherapeutic and psychopharmacological treatment efficacy, and mental health services effectiveness are encouraged. The Journal also seeks to promote the well-being of children and families by publishing scholarly papers on such subjects as health policy, legislation, advocacy, culture and society, and service provision as they pertain to the mental health of children and families. http://www.jaacap.org

About Elsevier

As a global leader in information and analytics, Elsevier helps researchers and healthcare professionals advance science and improve health outcomes for the benefit of society. We do this by facilitating insights and critical decision-making for customers across the global research and health ecosystems.

In everything we publish, we uphold the highest standards of quality and integrity. We bring that same rigor to our information analytics solutions for researchers, health professionals, institutions and funders.

Elsevier employs 8,100 people worldwide. We have supported the work of our research and health partners for more than 140 years. Growing from our roots in publishing, we offer knowledge and valuable analytics that help our users make breakthroughs and drive societal progress. Digital solutions such as ScienceDirect, Scopus, SciVal, ClinicalKey and Sherpath support strategic research management, R&D performance, clinical decision support, and health education. Researchers and healthcare professionals rely on our 2,500+ digitized journals, including The Lancet and Cell, our 40,000 e-book titles; and our iconic reference works, such as Gray's Anatomy. With the Elsevier Foundation and our external Inclusion & Diversity Advisory Board, we work in partnership with diverse stakeholders to advance inclusion and diversity in science, research and healthcare in developing countries and around the world.

Elsevier is part of RELX, a global provider of information-based analytics and decision tools for professional and business customers. http://www.elsevier.com

Media contact

JAACAP Editorial Office
+1 202 587 9674
support@jaacap.org

Elsevier

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