Celecoxib shows surprising activity against estrogen receptors

December 10, 2004

Six months of treatment with celecoxib (Celebrex) in women at risk of developing breast cancer results in the reduction of estrogen receptor expression in breast cells, a research team at The University of Texas M. D. Anderson Cancer Center has found.

The surprising insight - that celecoxib may regulate a cell's use of estrogen - could help explain the drug's observed anticancer properties, says the study's lead author, Banu Arun, M.D., associate professor in the Department of Breast Medical Oncology.

"Since estrogen receptor expression is a marker of proliferation, this finding confirms celecoxib's antiproliferative properties," she says. "This is a preliminary, but exciting, finding that has not been reported in clinical chemoprevention studies before."

To date, the study has enrolled 40 women at high risk of developing breast cancer. Each woman agreed to undergo a fine needle aspiration and ductal lavage to remove breast epithelium cells both before and after six months of celecoxib treatment. These samples were available for analysis in 26 high-risk women. The researchers assessed the difference in estrogen receptor levels before and after treatment.

They found that the average pre- and post-treatment estrogen receptor expression was 30.8 percent and 21.8 percent, respectively, which is a statistically significant difference. Arun says they are continuing to examine the impact of celecoxib on other cancer risk markers in breast cells, such as EGFR, HER2, Ki-67 and Bcl-2.
-end-


University of Texas M. D. Anderson Cancer Center

Related Estrogen Articles from Brightsurf:

Removal of synthetic estrogen from water
Synthetic estrogens from pharmaceuticals contaminate rivers and threaten the health of humans and fish.

Does estrogen influence alcohol use disorder?
A new study from researchers at the University of Illinois at Chicago shows that high estrogen levels may make alcohol more rewarding to female mice.

Estrogen's role in the sex differences of alcohol abuse
Fluctuating estrogen levels may make alcohol more rewarding to female mice, according to new research in JNeurosci.

Estrogen's opposing effects on mammary tumors in dogs
Estrogen's role in canine mammary cancer is more complex than previously understood, according to new research led by the University of Pennsylvania School of Veterinary Medicine.

Placenta transit of an environmental estrogen
The human foetus is considered to be particularly sensitive to environmental contaminants.

Estrogen improves Parkinson's disease symptoms
Brain-selective estrogen treatment improves the symptoms of Parkinson's disease in male mice, according to new research published in JNeurosci.

The sneaky way estrogen drives brain metastasis in non-estrogen-dependent breast cancers
University of Colorado Cancer Center study shows that while estrogen doesn't directly affect triple-negative breast cancer cells, it can affect surrounding brain cells in ways that promote cancer cell migration and invasiveness

New study demonstrates effectiveness and safety of vaginal estrogen
Despite its proven effectiveness in treating the genital symptoms of menopause, low-dose vaginal estrogen therapy remains underused largely because of misperceptions regarding its safety.

Hidden estrogen receptors in the breast epithelium
EPFL scientists have uncovered that next to estrogen receptor positive and negative there are cells with very low amounts of the receptor protein.

Estrogen may protect against depression after heart attack
Estrogen may protect against heart failure-related depression by preventing the production of inflammation-causing chemicals in the brain.

Read More: Estrogen News and Estrogen Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.