Estimates of ASD, ADHD risk in siblings born after older children with those disorders

December 10, 2018

Bottom Line: Siblings born in a family after other children with autism spectrum disorder (ASD) or attention-deficit/hyperactivity disorder (ADHD) were more likely to be diagnosed with the same disorder or the other disorder.

Why The Research Is Interesting: ADHD and ASD are common neurodevelopmental disorders that likely share some genetic factors and biological influences. Estimating recurrence risk in families is a way to measure shared genetic factors. Such risk estimates are often based on the total number of siblings in a family rather than being limited to later-born siblings (those born after children with ASD or ADHD) so that risk can be underestimated if families decide to stop having children after a child develops ASD or ADHD. This study focused on risk for later-born siblings.

Who and What: A total of 15,175 later-born siblings classified by familial risk based on an older child's diagnosis: ADHD risk (730), ASD risk (158) and no known risk (14,287); data were extracted from two large health care system in the United States.

How (Study Design): This was a population-based study.

Authors: Meghan Miller, Ph.D., of the University of California Davis Health System, Sacramento, California, and coauthors

Study Limitations: These include a selective sample, lack of information on half- or full-sibling status, and data drawn from general medical records.

Related Material: The editorial, "Later Sibling Recurrence of Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder: Clinical and Mechanistic Insights," by Tony Charman, Ph.D., of King's College London, and Emily J.H. Jones, Ph.D., of the University of London, both in the United Kingdom, also is available on the For The Media website.

To Learn More: The full study is available on the For The Media website.


Editor's Note: The article contains funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.
Want to embed a link to this study in your story? Link will be live at the embargo time

JAMA Network

Related ADHD Articles from Brightsurf:

Autism and ADHD share genes
Researchers from the national psychiatric project iPSYCH have found that autism and ADHD share changes in the same genes.

ADHD across racial/ethnic groups
This study of patients from diverse racial/ethnic backgrounds who received care at the Kaiser Permanente Northern California health system looked at how common attention-deficit/hyperactivity disorder (ADHD) diagnoses were over a 10-year period across seven racial/ethnic groups.

Cycles of reward: New insight into ADHD treatment
Researchers at the Okinawa Institute of Science and Technology Graduate University (OIST) in collaboration with scientists at the University of Otago and the University of Auckland in New Zealand, investigated the actions of the drug in rats.

Young mums more likely to have kids with ADHD
Young mothers have a greater chance of having a child with attention deficit hyperactivity disorder (ADHD) according to new research from the University of South Australia.

ADHD medication: How much is too much for a hyperactive child?
When children with ADHD don't respond well to Methylphenidate (MPH, also known as Ritalin) doctors often increase the dose.

Antipsychotic use in youths with ADHD is low, but still cause for concern
A new study eased fears about the proportion of youths with ADHD taking antipsychotic drugs, but still found that many prescriptions may be inappropriate.

How stimulant treatment prevents serious outcomes of ADHD
Analysis quantifies the extent which stimulant treatment reduces serious outcomes in children and young adults with ADHD.

Did Leonardo da Vinci have ADHD?
Leonardo da Vinci produced some of the world's most iconic art, but historical accounts show that he struggled to complete his works.

More sleep may help teens with ADHD focus and organize
Teenagers with attention deficit hyperactivity disorder (ADHD) may benefit from more sleep to help them focus, plan and control their emotions.

Researchers have found the first risk genes for ADHD
A major international collaboration headed by researchers from the Danish iPSYCH project, the Broad Institute of Harvard and MIT, Massachusetts General Hospital, SUNY Upstate Medical University, and the Psychiatric Genomics Consortium has for the first time identified genetic variants which increase the risk of ADHD.

Read More: ADHD News and ADHD Current Events is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to