Columbia University licenses next-generation DNA sequencing technology

December 11, 2006

Columbia University announces today that it recently executed an exclusive license agreement for a next generation DNA sequencing technology to Intelligent Bio-Systems (IBS), Inc. This innovative DNA-sequencing technology was invented by Dr. Jingyue Ju, professor of Chemical Engineering and head of DNA Sequencing and Chemical Biology at the Judith P. Sulzberger, M.D. Columbia Genome Center at Columbia University. The fundamentals of this new technology are being published on-line today by in the Proceedings of the National Academy of Sciences (PNAS). This research paper describes the details of the Sequencing by Synthesis Chemistry and how the approach overcomes accuracy limitations of other next generation DNA sequencing systems.

It was also recently announced that Columbia University in collaboration with the Waltham, Mass. based Intelligent Bio-Systems, is one of only two recipients of the Near-Term Technology Development for Genome Sequencing grants from the National Human Genome Research Institute (NHGRI) of the National Institutes of Health (NIH) (www.genome.gov/19518500). This grant of $425,000 is for the development of a "High-Throughput DNA Sequencing by Synthesis Platform."

"The collaboration between Dr. Ju at Columbia and Intelligent Bio-Systems is an important development to bring this powerful technology to both researchers and clinicians in the near future," said Dr. Steven Gordon, Chief Executive Officer at IBS. "Completing the license was a key step in uniting Dr. Ju's seminal sequencing chemistry and IBS's molecular biology and engineering expertise. We are poised to offer a simple, cost effective platform that will enable many researchers and clinicians to use this next-generation DNA sequencing technology in their own laboratories."

Dr. Ju is a prolific inventor of new technologies for applications in genomics using chemistry and molecular engineering approaches. He is credited with being one of the primary inventors of the fluorescent energy transfer chemistry for 4-color Sanger sequencing being used by virtually all of the current generations of DNA sequencers that were used to complete the Human Genome Project.
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About Columbia Genome Center

From its conception in 1995, the Judith P. Sulzberger, M.D., Columbia Genome Center (CGC) has served as a bridge between the biomedical and science/engineering communities of the two Columbia University campuses, the main campus in Morningside Heights and the Medical Center campus in Washington Heights. The CGC was born as an interdisciplinary consortium of scientists and engineers dedicated to the generation of technology, information science, systems biology, and population genetic theory required to transform information from the genome to the study of biology and the practice of medicine. Today, more than 70 scientists collaborate on initiatives to further illuminate the genome.

About Columbia University

Founded in 1754 as King's College, Columbia University in the City of New York is the fifth oldest institution of higher learning in the United States and is one of the world's leading academic and research institutions, conducting pathbreaking research in medicine, science, engineering, the arts, and the humanities. For more information about Columbia University, visit www.columbia.edu.

About Intelligent Bio-Systems, Inc.

Intelligent Bio-Systems, Inc. is a privately held company located in Waltham, Mass. Since founding in 2005 it has focused on the development of next-generation DNA sequencing, gene expression and diagnostic systems based on proprietary instruments, chemistry, and consumables. The company has committed to deliver working instruments to the laboratories of a few early access collaborators during the coming year.

Columbia University Medical Center

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