Unexpectedly, data show that anaesthetists and intensive care doctors are at lower risk of SARS-CoV-2 infection compared with other medical staff

December 11, 2020

Following the first recorded death of an anaesthetist from COVID-19 in the UK in November 2020, a review of available data published in Anaesthesia (a journal of the Association of Anaesthetists) shows that unexpectedly, despite their perceived increased exposure to COVID-19 patients and high-risk procedures, anaesthetists and intensive care doctors appear to be at lower risk of being infected with SARS-CoV-2 and developing COVID-19.

The analysis was carried out by Professor Tim Cook, Consultant in Anaesthesia and Intensive Care Medicine, Royal United Hospitals Bath NHS Foundation Trust, Bath, UK, and School of Medicine, University of Bristol, UK, and Dr Simon Lenanne, General Practitioner, Ross-on-Wye, Herefordshire, UK. The authors undertook the review following the death on November 12, 2020, of anaesthetist Dr Krishnan Subramanian, who was aged 46 years and worked at the Royal Derby Hospital, UK.

"This very sad event is a moment for pause and reflection. Every death is a tragedy, and our first thoughts should be with Dr Subramanian's family, friends and colleagues," say the authors.

Reviewing numerous studies, the authors say that overall, healthcare workers in patient-facing roles are at two- to four-fold increased risk of infection and harm from COVID-19. Household members of healthcare staff are also at increased risk. However, it remains uncertain whether working in a patient-facing healthcare role significantly increases the risk of death from COVID-19.

"Three separate studies from Oxford, Leicester and Birmingham and including more than 20,000 healthcare staff indicate that those working in anaesthesia and intensive care had less than half the risk of infection than physicians dealing with COVID-19 patients on the wards. These studies also found significantly higher rates of infection in both front-line nurses and housekeeping staff compared to anaesthetists and intensivists," say the authors. "And in a study of Scottish of hospital admission of healthcare workers, working in ICU was again associated with approximately half the risk of working in 'front door' roles. Even household contacts of 'front door' healthcare workers had a higher risk of hospital admission than those working in ICU."

The authors also conducted an analysis to explore whether deaths of anaesthetists were lower than expected amongst the general population and amongst healthcare workers. Using data from The Royal College of Anaesthetists census, NHS Digital, the Office of National Statistics, and their own database of healthcare worker deaths the authors compared the expected and observed number of deaths amongst UK anaesthetists/ intensivists with various comparator groups.

Overall deaths amongst anaesthetists and intensivists were disproportionately low - ranging between less than a half to a quarter of expected deaths based on the numbers working in this speciality. The number of deaths expected among anaesthetists, based on representation of anaesthetists among doctors, and COVID-19 related deaths among the general population would be several times higher than the single death recorded so far (3 or 4 in total).

The authors explain: "This analysis indicates that, irrespective of the comparator group used, deaths among anaesthetists and intensivists are notably lower than expected and certainly not high, as some would have predicted."

The authors offer several possible explanations for the lower risk observed. These include better personal protective equipment or better use of it, working in well-ventilated environments and the possibilities that both the patients who are admitted to ICU are less infectious than those on the wards, and that the high risk procedures such as establishing a patient on a ventilator (including intubation) are not as high risk as has been assumed.

The authors say: "This analysis highlights both the relative safety of anaesthetists and intensivists from occupational harm from SARS-CoV-2 and the increased risks for others working on the wards, both in clinical and non-clinical roles."

They conclude: "It is our opinion that those working in anaesthesia and critical care should continue with current practices to maintain their own safety and that of their working environment. A more challenging question is whether some of the procedures that appear to keep anaesthetists and intensivists safe such as high level protective respirators should be extended to general practice and the wards where other healthcare workers are more at risk."

Dr Mike Nathanson, President of the Association of Anaesthetists, said: "The whole profession was saddened to hear of the tragic death of Dr Krishnan Subramanian. It is reassuring to see that, to date, we have lost no further anaesthestists or intensivists to COVID-19 despite their involvement on the front line of battling this pandemic. The death of each healthcare worker has been in our minds, however. This analysis reminds us of the risks, and of factors that may explain why anaesthetists and intensivists appear to have so far largely escaped the worst of this illness. We are not complacent, and we will continue to work for the wellbeing of the anaesthetists and intensivists we represent."


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