Glomerular fibrosis now all the RAGE

December 12, 2001

Oldfield et al. have identified a crucial pathological role for the multifaceted receptor RAGE ? the receptor for advanced glycation end products (AGEs). AGEs form spontaneously when reducing sugars react with lysine residues on extracellular proteins. Even in healthy individuals, they accumulate inexorably during aging, but this progression is particularly swift in diabetics, reflecting the higher glucose levels in their tissues during periods of hyperglycemia. Activation of RAGE by these ligands is associated with several disorders, and Oldfield and colleagues now propose that tubulointerstitial disease, a form of diabetic nephropathy, should be added to this list. The cell-type transformation, or trans-differentiation, of normal kidney epithelial cells to collagen-secreting myofibroblasts, is thought to drive this disease process. The authors show that RAGE signaling is required to induce trans-differentiation in cultured kidney cells and rat kidney tissue, and probably also in the diabetic human kidney. In the rat system, a drug that removes sugar adducts on proteins prevents trans-differentiation. This treatment also limits the secretion of TGF-b, which appears to mediate the effects of RAGE signaling on the phenotype of kidney cells. Consistent with this model, Oldfield et al. note that another inhibitor of AGE formation has also been reported to suppress RAGE-dependent activation of TGF-b in diabetic animals.
-end-


JCI Journals

Related Aging Articles from Brightsurf:

Surprises in 'active' aging
Aging is a process that affects not only living beings.

Aging-US: 'From Causes of Aging to Death from COVID-19' by Mikhail V. Blagosklonny
Aging-US recently published ''From Causes of Aging to Death from COVID-19'' by Blagosklonny et al. which reported that COVID-19 is not deadly early in life, but mortality increases exponentially with age - which is the strongest predictor of mortality.

Understanding the effect of aging on the genome
EPFL scientists have measured the molecular footprint that aging leaves on various mouse and human tissues.

Muscle aging: Stronger for longer
With life expectancy increasing, age-related diseases are also on the rise, including sarcopenia, the loss of muscle mass due to aging.

Aging memories may not be 'worse, 'just 'different'
A study from the Department of Psychological & Brain Sciences in Arts & Sciences adds nuance to the idea that an aging memory is a poor one and finds a potential correlation between the way people process the boundaries of events and episodic memory.

A new biomarker for the aging brain
Researchers at the RIKEN Center for Biosystems Dynamics Research (BDR) in Japan have identified changes in the aging brain related to blood circulation.

Scientists invented an aging vaccine
A new way to prevent autoimmune diseases associated with aging like atherosclerosis, Alzheimer's disease, and Parkinson's disease was described in the article.

The first roadmap for ovarian aging
Infertility likely stems from age-related decline of the ovaries, but the molecular mechanisms that lead to this decline have been unclear.

Researchers discover new cause of cell aging
New research from the USC Viterbi School of Engineering could be key to our understanding of how the aging process works.

Deep Aging Clocks: The emergence of AI-based biomarkers of aging and longevity
The advent of deep biomarkers of aging, longevity and mortality presents a range of non-obvious applications.

Read More: Aging News and Aging Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.