Doctors should reduce penicillin use for women in labor, study shows

December 12, 2001

COLUMBUS, Ohio - Nearly a quarter of the estimated 4 million women who give birth each year in the United States receive an antibiotic during labor in order to protect their infants from developing a serious infection.

But these women may be getting five times the necessary dose of medication, say Ohio State University researchers.

"Physicians may be using too much penicillin," said researcher David Colombo. "There is a shortage of this type of penicillin - the kind that is given intravenously. Also, we worry that the overuse of antibiotics overall will lead to the increased resistance of harmful bacteria to these drugs."

Penicillin is the most common antibiotic given to a woman at risk of transferring the bacteria group B Streptococcus (GBS) to her newborn. Penicillin protects the baby against GBS, which can cause sepsis, a sometimes-fatal blood infection.

The Centers for Disease Control and Prevention recommend that these women get about 3 grams of penicillin (5 million units) when labor begins, followed by 1.5 grams (2.5 million units) every four hours until delivery. But a dose of about 0.5 grams (1 million units) given initially and again every four hours until delivery may give the same protective effect, said Colombo, an assistant professor of obstetrics and gynecology at Ohio State.

The study appears in a recent issue of the American Journal of Obstetrics and Gynecology.

Fifteen healthy pregnant women in their third trimester of pregnancy, but who were not yet in labor, were given one 0.5-gram dose of intravenous penicillin. The researchers wanted to analyze the concentration of penicillin in each woman's blood, so they took blood samples via a catheter at one, five, 15 and 30 minutes after the initial dose and then once every 30 minutes for a total of four hours.

They found that this lower dosage of penicillin is excreted from the body at the same rate as does the 3- and 1.5-gram doses, suggesting that a lower dosage of penicillin provides levels sufficient enough to protect a newborn from infection caused by GBS.

"The baby is really the one who is being treated," said Colombo. "We can give the 0.5 gram doses of penicillin to mothers in labor and get the same beneficial results as we do with the larger doses."

Babies born prematurely (before 37 weeks - 40 weeks is considered a full-term pregnancy) are at particularly high risk for GBS-induced infection. All mothers who give birth prematurely are given penicillin or ampicillin (another form of penicillin) during labor, Colombo said.

Babies carried full-term and born to mothers with high levels of GBS in the vaginal and colon areas are also at risk of developing an infection. In addition, newborns are at risk if their mothers' amniotic membranes have been ruptured for 18 hours or longer (that is, if her water has broken); if the mother has a fever at the time of delivery; or if she gave birth to a previously infected child.

"We test all pregnant women at 36 weeks, and treat them during labor if the culture comes back positive," Colombo said. "One in three women have group B strep in their system. It can't be eradicated - it lives in the colon."
-end-
This research was supported by a grant from the general clinical research center at Ohio State.

Colombo conducted the study with Jeffrey Johnson, Debra Gardner and Cynthia Shellhaas, all of Ohio State's College of Medicine and Public Health, division of maternal-fetal medicine; and Eunsun Cho and Patty Fan-Havard, both in the College of Pharmacy at Ohio State.

Contact: David Colombo, 614-293-4652; Colombo.4@osu.edu
Written by Holly Wagner, 614-292-8310; Wagner.235@osu.edu


Ohio State University

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