Widespread brain atrophy detected in Parkinson's disease with newly developed structural pattern

December 12, 2011

PHILADELPHIA - Atrophy in the hippocampus, the region of the brain known for memory formation and storage, is evident in Parkinson's disease (PD) patients with cognitive impairment, including early decline known as mild cognitive impairment (MCI), according to a study by researchers in the Perelman School of Medicine at the University of Pennsylvania. The study is published in the December issue of the Archives of Neurology, one of the JAMA/Archives journals.

First, using traditional imaging analyses, researchers found that Parkinson's patients with MCI had more atrophy in the hippocampus, basal ganglia, amygdala, and insula compared with Parkinson's patients with normal cognition, whereas Parkinson's patients with normal cognition showed no significant loss of brain volume compared with healthy controls. For Parkinson's patients with full-blown dementia, atrophy was present not only in the hippocampus but also the surrounding medial temporal lobe, also crucial to memory and other cognitive abilities.

Then researchers generated the first structural pattern of classifying brain atrophy associated with dementia in Parkinson's disease by analyzing the scans of PD with either dementia or normal cognition.

"When we layer different information gathered from structural MRIs and generate a structural pattern that weighs different brain regions on their ability to distinguish PD with dementia from those with normal cognition, we can see a pattern of diffuse gray matter and white matter atrophy in the brains of Parkinson's patients with cognitive decline," explains the study's lead author, Daniel Weintraub, MD, associate professor of Geriatric Psychiatry with Penn's Perelman School of Medicine and the Philadelphia Veterans Affairs Medical Center. "This complex analysis of brain imaging data suggests that it is possible to detect a wide range of brain atrophy at the initial stages of cognitive decline in patients with Parkinson's disease, which has not been reported previously."

As Parkinson's-related mild cognitive impairment (PD-MCI) is increasingly recognized as an important clinical syndrome of possible precursor of Parkinson's dementia, biomarkers with good screening or diagnostic validity can help categorize levels of cognitive impairment, may predict future cognitive decline, and may ultimately help inform treatment decisions.

The neurodegeneration that contributes to cognitive decline seen in Parkinson's, particularly in regions of the brain known to play a role in Alzheimer's disease, such as the hippocampus, is likely due to a "complex interaction of different disease pathologies," the researchers said. Approximately 80 percent of Parkinson's disease patients ultimately develop dementia.

Parkinson's patients with normal cognition showed no atrophy and had similar brain volumes to healthy controls without Parkinson's or cognitive impairment. Therefore, researchers believe that significant brain atrophy in areas subserving cognition does not occur in Parkinson's disease without a comorbid cognitive impairment.

Eighty-four Parkinson's patients from the Penn Parkinson's Disease and Movement Disorders Center and 23 healthy controls received MRIs of the brain. Of the 84 Parkinson's patients, 61 had normal cognition, 12 were classified as having mild cognitive impairment, and 11 were diagnosed with Parkinson's disease dementia.
-end-
The research team included Dr. Weintraub, Jimit Doshi, MS, Deepthi Koka, MS, Christos Davatzikos, PhD, Andrew Siderowf, MD, MSCE, John Duda, MD, David Wolk, MD, Paul Moberg, PhD, Sharon Xie, PhD, and Christopher Clark, MD, representing the Penn Udall Center for Parkinson's Research and the Perelman School of Medicine's departments of Psychiatry, Neurology, Radiology, Biostatistics and Epidemiology. Dr. Weintraub and Dr. Duda are also with Philadelphia Veterans Affairs Medical Center. Dr. Clark is with Avid Radiopharmaceuticals.

The study was funded by grants from the National Institutes of Health's National Institute of Neurological Disorders and Strokes and National Institute of Aging, as well as a grant awarded by Department of Health of the Commonwealth of Pennsylvania from the Tobacco Master Settlement Agreement.

Penn Medicine is one of the world's leading academic medical centers, dedicated to the related missions of medical education, biomedical research, and excellence in patient care. Penn Medicine consists of the Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania (founded in 1765 as the nation's first medical school) and the University of Pennsylvania Health System, which together form a $4 billion enterprise.

Penn's Perelman School of Medicine is currently ranked #2 in U.S. News & World Report's survey of research-oriented medical schools and among the top 10 schools for primary care. The School is consistently among the nation's top recipients of funding from the National Institutes of Health, with $507.6 million awarded in the 2010 fiscal year.

The University of Pennsylvania Health System's patient care facilities include: The Hospital of the University of Pennsylvania -- recognized as one of the nation's top 10 hospitals by U.S. News & World Report; Penn Presbyterian Medical Center; and Pennsylvania Hospital - the nation's first hospital, founded in 1751. Penn Medicine also includes additional patient care facilities and services throughout the Philadelphia region.

Penn Medicine is committed to improving lives and health through a variety of community-based programs and activities. In fiscal year 2010, Penn Medicine provided $788 million to benefit our community.

University of Pennsylvania School of Medicine

Related Dementia Articles from Brightsurf:

The danger of Z-drugs for dementia patients
Strong sleeping pills known as 'Z-drugs' are linked with an increased risk of falls, fractures and stroke among people with dementia, according to new research.

The long road to dementia
Alzheimer's disease develops over decades. It begins with a fatal chain reaction in which masses of misfolded beta-amyloid proteins are produced that in the end literally flood the brain.

Why people with dementia go missing
People with dementia are more likely to go missing in areas where road networks are dense, complicated and disordered - according to new research from the University of East Anglia.

PTSD may double risk of dementia
People who have experienced post-traumatic stress disorder (PTSD) are up to twice as likely to develop dementia later in life, according to a new study by UCL researchers, published in the British Journal of Psychiatry.

Dementia education
School-based dementia education could deliver much needed empathy and understanding for older generations as new research from the University of South Australia shows it can significantly improve dementia knowledge and awareness among younger generations.

Building dementia friendly churches
A project to help church communities become more 'dementia friendly' has had a significant impact across the country.

A "feeling" for dementia?
A research team led by the DZNE concludes that personal perception can be an important indicator for the early detection of Alzheimer's disease.

New biomarker for dementia diagnosis
Medical researchers in the UK and Australia have identified a new marker which could support the search for novel preventative and therapeutic treatments for dementia.

Digital solutions for dementia care
Telehealth delivery of dementia care in the home can be as effective as face-to-face home visit services if carers and recipients take advantage of the technologies available, Australian researchers say.

Despite a marked reduction in the prevalence of dementia, the number of people with dementia is set to double by 2050 according to new Alzheimer Europe report
Today, at a European Parliament lunch debate, Alzheimer Europe launched a new report presenting the findings of its collaborative analysis of recent prevalence studies and setting out updated prevalence rates for dementia in Europe.

Read More: Dementia News and Dementia Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.