New study shows link between perfluorinated compounds and diabetes

December 12, 2013

Perfluorinated compounds are environmental toxins that are found in fire extinguishing foam and water-repellent textiles and, for example. In a new study, a research team led from Uppsala University has seen links between high levels of perfluorinated compounds in the blood and diabetes.

The research group at Uppsala University has previously shown associations between high levels of environmental toxins, such as PCB, pesticides, and phthalates and diabetes. In the new study they have investigated whether elevated levels of another type of environmental toxin, so-called perfluorinated compounds, are related to diabetes. Perfluorinated compounds are used in a wide variety of industrial and consumer products, including fire fighting foam, non-stick cookware, and grease and water-repellent materials such as food contact material, ski wax and GoreTex , for example.

In a group of more than a thousand 70-year-old men and women from Uppsala, levels of seven different perfluorinated compounds were measured in the blood and related to whether the individuals had diabetes (114 persons) or not. These seven perfluorinated compounds was detectable in virtually all individuals in the study.

We saw that high levels, especially of one of the perfluorinated compounds, perfluorononanoic acid (PFNA), were linked to diabetes. Perfluorooctanoic acid (PFOA) was also associated with diabetes in this group. We also saw that PFOA was linked to disrupted secretion of insulin from the pancreas, explains Monica Lind, associate professor at the Division of Occupational and Environmental Medicine at Uppsala University.

The study raises the question of whether high levels of certain perfluorinated compounds, which were found in all individuals in this study, are linked to the development of diabetes.
-end-
The study is part of the so-called PIVUS study at Uppsala University.

For more information, please contact Lars Lind, professor at the Department of Medical Sciences, mobile: +46 (0)73-050 28 78, lars.lind@medsci.uu.se or Monica Lind, associate professor of environmental medicine, mobile: +46 (0)70-320 30 66, monica.lind@medsci.uu.se

L. Lind, B. Zethelius, S. Salihovic, B. van Bavel, P. M. Lind (2013) Circulating levels of perfluoroalkyl substances and prevalent diabetes in the elderly, Diabetologia

Read the article in Diabetologia: http://www.diabetologia-journal.org/files/Lind.pdf

Uppsala University

Related Diabetes Articles from Brightsurf:

New diabetes medication reduced heart event risk in those with diabetes and kidney disease
Sotagliflozin - a type of medication known as an SGLT2 inhibitor primarily prescribed for Type 2 diabetes - reduces the risk of adverse cardiovascular events for patients with diabetes and kidney disease.

Diabetes drug boosts survival in patients with type 2 diabetes and COVID-19 pneumonia
Sitagliptin, a drug to lower blood sugar in type 2 diabetes, also improves survival in diabetic patients hospitalized with COVID-19, suggests a multicenter observational study in Italy.

Making sense of diabetes
Throughout her 38-year nursing career, Laurel Despins has progressed from a bedside nurse to a clinical nurse specialist and has worked in medical, surgical and cardiac intensive care units.

Helping teens with type 1 diabetes improve diabetes control with MyDiaText
Adolescence is a difficult period of development, made more complex for those with Type 1 diabetes mellitus (T1DM).

Diabetes-in-a-dish model uncovers new insights into the cause of type 2 diabetes
Researchers have developed a novel 'disease-in-a-dish' model to study the basic molecular factors that lead to the development of type 2 diabetes, uncovering the potential existence of major signaling defects both inside and outside of the classical insulin signaling cascade, and providing new perspectives on the mechanisms behind insulin resistance in type 2 diabetes and possibly opportunities for the development of novel therapeutics for the disease.

Tele-diabetes to manage new-onset diabetes during COVID-19 pandemic
Two new case studies highlight the use of tele-diabetes to manage new-onset type 1 diabetes in an adult and an infant during the COVID-19 pandemic.

Genetic profile may predict type 2 diabetes risk among women with gestational diabetes
Women who go on to develop type 2 diabetes after having gestational, or pregnancy-related, diabetes are more likely to have particular genetic profiles, suggests an analysis by researchers at the National Institutes of Health and other institutions.

Maternal gestational diabetes linked to diabetes in children
Children and youth of mothers who had gestational diabetes during pregnancy are at increased risk of diabetes themselves, according to new research published in CMAJ (Canadian Medical Association Journal).

Two diabetes medications don't slow progression of type 2 diabetes in youth
In youth with impaired glucose tolerance or recent-onset type 2 diabetes, neither initial treatment with long-acting insulin followed by the drug metformin, nor metformin alone preserved the body's ability to make insulin, according to results published online June 25 in Diabetes Care.

People with diabetes visit the dentist less frequently despite link between diabetes, oral health
Adults with diabetes are less likely to visit the dentist than people with prediabetes or without diabetes, finds a new study led by researchers at NYU Rory Meyers College of Nursing and East Carolina University's Brody School of Medicine.

Read More: Diabetes News and Diabetes Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.