Exercise following weight loss may reduce colorectal cancer risk, study finds

December 12, 2018

Rockville, Md. (December 12, 2018)--New research suggests that exercise is a key factor in reducing colorectal cancer risk after weight loss. According to the study, physical activity causes beneficial changes in the bone marrow. The study is published ahead of print in the American Journal of Physiology--Endocrinology and Metabolism.

Colorectal cancer is one of the most common cancers worldwide. Occurrence of colorectal cancer is on the rise among young adults in the U.S. Previous research has shown that obesity and lack of physical activity increases the risk of developing this type of cancer. Recent studies have found that cells in bone marrow that produce blood cells (hematopoietic cells) play a role in the development of cancerous tumors in the colon. However, less is known about how losing weight through diet and exercise affects hematopoietic cells and decreases cancer risk.

An international research team from the University of Ottawa in Canada and the University of Illinois at Urbana-Champaign studied a mouse model of colorectal cancer. The mice--all of which had cancer--were fed a high-fat diet and became obese before being placed on a typical rodent diet for the remainder of the study. After two months of weight loss while following the typical diet, half the mice were exercised daily and half remained sedentary.

The researchers found that even after weight loss, the sedentary mice had higher levels of colon and bone marrow inflammation as well as more fat tissue accumulation in the bone marrow. The lack of exercise also caused inflammation-causing changes in the hematopoietic cells. The mice that were exercised had less inflammation and tumor formation after weight loss. The rate of tumor formation in the exercise group was similar to that of control mice that were exposed to cancer cells but were never obese. "Obesity induces long-term changes in [blood cell development] and the bone marrow microenvironment that persists even when weight and body composition improved," the research team wrote.

"These findings suggest that persons at increased risk of developing [colorectal cancer], such as those with obesity, should consider including exercise training with dietary interventions to decrease [colorectal cancer] risk," the researchers wrote.
-end-
Read the full article, "Effects of obesity and exercise on colon cancer induction and hematopoiesis in mice," published ahead of print in the American Journal of Physiology--Endocrinology and Metabolism.

NOTE TO JOURNALISTS: To schedule an interview with a member of the research team, please contact the communications@the-aps.org>APS Communications Office or 301-634-7314. Find more research highlights in the APS Press Room.

Physiology is the study of how molecules, cells, tissues and organs function in health and disease. Established in 1887, the American Physiological Society (APS) was the first U.S. society in the biomedical sciences field. The Society represents more than 10,000 members and publishes 15 peer-reviewed journals with a worldwide readership.

American Physiological Society

Related Obesity Articles from Brightsurf:

11 years of data add to the evidence for using testosterone therapy to treat obesity, including as an alternative to obesity surgery
New research covering 11 years of data presented at this year's European and International Congress on Obesity (ECOICO 2020) show that, in obese men suffering from hypogonadism (low testosterone), treatment with testosterone injections lowers their weight and improves a wide range of other metabolic parameters.

Overlap between immunology of COVID-19 and obesity could explain the increased risk of death in people living with obesity, and also older patients
Data presented in a special COVID-19 session at the European and International Congress on Obesity (ECOICO 2020) suggests that there are overlaps between the immunological disturbances found in both COVID-19 disease and patients with obesity, which could explain the increased disease severity and mortality risk faced by obese patients, and also elderly patients, who are infected by the SARS-CoV-2 virus that causes COVID-19 disease.

New obesity guideline: Address root causes as foundation of obesity management
besity management should focus on outcomes that patients consider to be important, not weight loss alone, and include a holistic approach that addresses the root causes of obesity, according to a new clinical practice guideline published in CMAJ (Canadian Medical Association Journal) http://www.cmaj.ca/lookup/doi/10.1503/cmaj.191707.

Changing the debate around obesity
The UK's National Health Service (NHS) needs to do more to address the ingrained stigma and discrimination faced by people with obesity, says a leading health psychologist.

Study links longer exposure to obesity and earlier development of obesity to increased risk of type 2 diabetes
Cumulative exposure to obesity could be at least as important as actually being obese in terms of risk of developing type 2 diabetes (T2D), concludes new research published in Diabetologia (the journal of the European Association for the Study of Diabetes [EASD]).

How much do obesity and addictions overlap?
A large analysis of personality studies has found that people with obesity behave somewhat like people with addictions to alcohol or drugs.

Should obesity be recognized as a disease?
With obesity now affecting almost a third (29%) of the population in England, and expected to rise to 35% by 2030, should we now recognize it as a disease?

Is obesity associated with risk of pediatric MS?
A single-center study of 453 children in Germany with multiple sclerosis (MS) investigated the association of obesity with pediatric MS risk and with the response of first-line therapy in children with MS.

Women with obesity prior to conception are more likely to have children with obesity
A systematic review and meta-analysis identified significantly increased odds of child obesity when mothers have obesity before conception, according to a study published June 11, 2019 in the open-access journal PLOS Medicine by Nicola Heslehurst of Newcastle University in the UK, and colleagues.

Obesity medicine association announces major updates to its adult obesity algorithm
The Obesity Medicine Association (OMA) announced the immediate availability of the 2019 OMA Adult Obesity Algorithm, with new information for clinicians including the relationship between Obesity and Cardiovascular Disease, Diabetes Mellitus, Dyslipidemia, and Cancer; information on investigational Anti-Obesity Pharmacotherapy; treatments for Lipodystrophy; and Pharmacokinetics and Obesity.

Read More: Obesity News and Obesity Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.