Treatment with SN reduces injury to the brain following stroke

December 13, 2007

Stroke is the term used to describe deteriorating brain function due to either the leaking of blood vessels (hemorrhage) or oxygen deprivation (ischemia) in the brain. Secretoneurin (SN) is a neural protein with various roles in the normal functioning of the brain and nervous system. For example, SN increases blood vessel formation in mouse corneas, and its production is increased following transient brain ischemia in gerbils. In a new study, a team of researchers from the Academia Sinica, Republic of China, and the China Medical University, Republic of China, have revealed a neuroprotective role for SN in a rat model of stroke.

SN production by rats was found to be increased in neuronal and endothelial brain cells following the induction of ischemia in the brain. In vitro, SN treatment improved the survival of primary brain cell cultures subjected to oxygen/glucose deprivation. Cell rescue was dependent on SN-induced expression of proteins that prevent a form of cell death called apoptosis. Furthermore, when rats with ischemia-induced stroke were injected with SN, they exhibited reduced cerebral tissue death, improved motor performance, and enhanced brain function. In addition, stem cell targeting to the brain and subsequent blood vessel formation were also incited by SN injection in these animals. From these results, the authors suggest that SN holds promise as a powerful small-molecule drug in the treatment of stroke.
TITLE: Secretoneurin promotes neuroprotection and neuronal plasticity via the Jak2/Stat3 pathway in murine models of stroke


Hung Li
Academia Sinica, Nankang, Taipei, Republic of China.
Phone: 886-2-2788-0460; Fax: 886-2-2782-6085; E-mail:

Woei-Cherng Shyu
China Medical University and Hospital, Taichung, Taiwan, Republic of China.
Phone: 886-4-2205-2121 ext. 6034; Fax: 886-4-2208-0666; E-mail:

View the PDF of this article at:

JCI Journals

Related Stroke Articles from Brightsurf:

Stroke alarm clock may streamline and accelerate time-sensitive acute stroke care
An interactive, digital alarm clock may speed emergency stroke care, starting at hospital arrival and through each step of the time-sensitive treatment process.

Stroke patients with COVID-19 have increased inflammation, stroke severity and death
Stroke patients who also have COVID-19 showed increased systemic inflammation, a more serious stroke severity and a much higher rate of death, compared to stroke patients who did not have COVID-19, according a retrospective, observational, cross-sectional study of 60 ischemic stroke patients admitted to UAB Hospital between late March and early May 2020.

'Time is vision' after a stroke
University of Rochester researchers studied stroke patients who experienced vision loss and found that the patients retained some visual abilities immediately after the stroke but these abilities diminished gradually and eventually disappeared permanently after approximately six months.

More stroke awareness, better eating habits may help reduce stroke risk for young adult African-Americans
Young African-Americans are experiencing higher rates of stroke because of health conditions such as high blood pressure, diabetes and obesity, yet their perception of their stroke risk is low.

How to help patients recover after a stroke
The existing approach to brain stimulation for rehabilitation after a stroke does not take into account the diversity of lesions and the individual characteristics of patients' brains.

Kids with headache after stroke might be at risk for another stroke
A new study has found a high incidence of headaches in pediatric stroke survivors and identified a possible association between post-stroke headache and stroke recurrence.

High stroke impact in low- and middle-income countries examined at 11th World Stroke Congress
Less wealthy countries struggle to meet greater need with far fewer resources.

Marijuana use might lead to higher risk of stroke, World Stroke Congress to be told
A five-year study of hospital statistics from the United States shows that the incidence of stroke has risen steadily among marijuana users even though the overall rate of stroke remained constant over the same period.

We need to talk about sexuality after stroke
Stroke survivors and their partners are not adequately supported to deal with changes to their relationships, self-identity, gender roles and intimacy following stroke, according to new research from the University of Sydney.

Standardized stroke protocol can ensure ELVO stroke patients are treated within 60 minutes
A new study shows that developing a standardized stroke protocol of having neurointerventional teams meet suspected emergent large vessel occlusion (ELVO) stroke patients upon their arrival at the hospital achieves a median door-to-recanalization time of less than 60 minutes.

Read More: Stroke News and Stroke Current Events is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to