Molecular insight into wound healing

December 14, 2001

Scientists have discovered a critical protein involved in skin inflammation. Published in Genes & Development, this study sheds new light on the molecular mechanism of wound healing and identifies a potential new drug target in the treatment of skin disorders like psoriasis.

The epidermis is the fist line of defense against injury and infection. When an injury is incurred, it is usually associated with skin inflammation. Dr. Walter Wahli and colleagues at the University of Lausanne in Basel, Switzerland have determined that the nuclear receptor protein PPARbeta (peroxisome proliferator-activated receptor beta) functions as a critical gene regulator in the cellular response to inflammation.

Upon injury, specialized epidermal cells called keratinocytes receive inflammatory signals that induce keratinocyte differentiation and migration to the site of injury, where they initiate the wound healing process. Dr. Wahli and colleagues have discovered that these inflammatory signals actually promote PPARbeta expression and the PPARbeta protein, in turn, activates the genes responsible for keratinocyte differentiation.

Dr. Wahli found that mice lacking PPARbeta are deficient in wound healing because there are an insufficient number of keratinocytes at the injury site. According to this study, PPARbeta functions by converting the inflammatory signal at the cell surface into an organized pattern of gene expression that enables keratinocytes to respond appropriately to injury.

In addition to wound healing, PPARbeta may be involved in other processes that involve inflammation-induced keratinocyte differentiation, like psoriasis. Further research will delineate the role of PPARbeta in such disorders and determine the utility of PPARbeta from a therapeutic perspective.
-end-


Cold Spring Harbor Laboratory

Related Inflammation Articles from Brightsurf:

3D printed stents that treat inflammation
POSTECH Professor Dong-Woo Cho's research team develops bioink-loaded esophageal stents for treating radiation esophagitis.

New cause of inflammation in people with HIV identified
A new study led by researchers at Boston Medical Center examined what factors could be contributing to this inflammation, and they identified the inability to control HIV RNA production from existing HIV DNA as a potential key driver of inflammation.

Maltreatment tied to higher inflammation in girls
New research by a University of Georgia scientist reveals that girls who are maltreated show higher levels of inflammation at an early age than boys who are maltreated or children who have not experienced abuse.

A protein that controls inflammation
A study by the research team of Prof. Geert van Loo (VIB-UGent Center for Inflammation Research) has unraveled a critical molecular mechanism behind autoimmune and inflammatory diseases such as rheumatoid arthritis, Crohn's disease, and psoriasis.

Inflammation in the brain linked to several forms of dementia
Inflammation in the brain may be more widely implicated in dementias than was previously thought, suggests new research from the University of Cambridge.

Social isolation could cause physical inflammation
Social isolation could be associated with increased inflammation in the body new research from the University of Surrey and Brunel University London has found.

Hydrogels control inflammation to help healing
Researchers test a sampling of synthetic, biocompatible hydrogels to see how tuning them influences the body's inflammatory response.

Why beta-blockers cause skin inflammation
Beta-blockers are often used to treat high blood pressure and other cardiovascular diseases.

The 'inflammation' of opioid use
New research correlates inflammation in the brain and gut to negative emotional state during opioid withdrawal.

Using a common anticonvulsant to counteract inflammation
The interaction between a chromosomal protein called HMGB1 and a cellular receptor called RAGE is known to trigger inflammation.

Read More: Inflammation News and Inflammation Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.