Physical activity associated with lower risk of mortality in men with history of colon cancer

December 14, 2009

Increased physical activity appears to be associated with a lower risk of cancer-specific and overall death in men with a history of colorectal cancer that has not spread to other parts of the body, according to a report in the December 14/28 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.

Approximately 150,000 Americans are newly diagnosed with colon cancer each year and almost 50,000 die of the disease annually, according to background information in the article. Although physical activity is known to help prevent the development of colon cancer, few studies have examined its effect on colon cancer survivors.

Jeffrey A. Meyerhardt, M.D., M.P.H., of Dana-Farber Cancer Institute, Boston, and colleagues studied the association of physical activity with colon cancer-specific and overall death in a group of 668 men with a history of stage I, stage II and stage III nonmetastatic (cancer that has not spread) colon cancer. Participants received follow-up questionnaires every two years to report new cancer and disease diagnoses as well as any leisure-time physical activity including walking, bicycling and other aerobic exercises; yoga, stretching and other lower-intensity exercise; or other vigorous activities. Each physical activity was assigned a metabolic equivalent task (MET) score. Activities that required more energy were assigned higher MET scores.

There were 258 deaths in the group of study participants, of which 88 were due to colon cancer. "Men who were physically active after diagnosis of nonmetastatic colorectal cancer experienced a significantly decreased risk of colorectal cancer-specific death, as well as death from any cause," the authors write. "Men who engaged in more than 27 MET hours per week had more than 50 percent lower risk of colorectal cancer-specific mortality compared with inactive men. This association was consistently detected regardless of age, disease stage, body mass index, diagnosis year, tumor location and prediagnosis physical activity."

"These results provide further support that physical activity after colorectal cancer diagnosis may lower the risk of death from that disease," the authors conclude. "A randomized study among high-risk stage II and stage III colon cancer survivors that will compare the use of general education materials with a program that includes supervised physical activity sessions and behavioral support delivered over three years will soon open; the primary end point is disease-free survival. The findings from the present study further support that effort."
-end-
(Arch Intern Med. 2009;169[22]:2102-2108. Available pre-embargo to the media at www.jamamedia.org.)

Editor's Note: This study was supported by grants from the National Institutes of Health. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

The JAMA Network Journals

Related Cancer Articles from Brightsurf:

New blood cancer treatment works by selectively interfering with cancer cell signalling
University of Alberta scientists have identified the mechanism of action behind a new type of precision cancer drug for blood cancers that is set for human trials, according to research published in Nature Communications.

UCI researchers uncover cancer cell vulnerabilities; may lead to better cancer therapies
A new University of California, Irvine-led study reveals a protein responsible for genetic changes resulting in a variety of cancers, may also be the key to more effective, targeted cancer therapy.

Breast cancer treatment costs highest among young women with metastic cancer
In a fight for their lives, young women, age 18-44, spend double the amount of older women to survive metastatic breast cancer, according to a large statewide study by the University of North Carolina at Chapel Hill.

Cancer mortality continues steady decline, driven by progress against lung cancer
The cancer death rate declined by 29% from 1991 to 2017, including a 2.2% drop from 2016 to 2017, the largest single-year drop in cancer mortality ever reported.

Stress in cervical cancer patients associated with higher risk of cancer-specific mortality
Psychological stress was associated with a higher risk of cancer-specific mortality in women diagnosed with cervical cancer.

Cancer-sniffing dogs 97% accurate in identifying lung cancer, according to study in JAOA
The next step will be to further fractionate the samples based on chemical and physical properties, presenting them back to the dogs until the specific biomarkers for each cancer are identified.

Moffitt Cancer Center researchers identify one way T cell function may fail in cancer
Moffitt Cancer Center researchers have discovered a mechanism by which one type of immune cell, CD8+ T cells, can become dysfunctional, impeding its ability to seek and kill cancer cells.

More cancer survivors, fewer cancer specialists point to challenge in meeting care needs
An aging population, a growing number of cancer survivors, and a projected shortage of cancer care providers will result in a challenge in delivering the care for cancer survivors in the United States if systemic changes are not made.

New cancer vaccine platform a potential tool for efficacious targeted cancer therapy
Researchers at the University of Helsinki have discovered a solution in the form of a cancer vaccine platform for improving the efficacy of oncolytic viruses used in cancer treatment.

American Cancer Society outlines blueprint for cancer control in the 21st century
The American Cancer Society is outlining its vision for cancer control in the decades ahead in a series of articles that forms the basis of a national cancer control plan.

Read More: Cancer News and Cancer Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.