A new kind of micro-mobility

December 14, 2009

A new microscopic system devised by researchers in MIT's department of materials science and engineering could provide a novel method for moving tiny objects inside a microchip, and could also provide new insights into how cells and other objects are propelled around within the body.

Inside organs such as the trachea and the intestines, tiny hair-like filaments called cilia are constantly in motion, beating in unison to create currents that sweep along cells, nutrients, or other tiny particles. The new research uses a self-assembling system to mimic that kind of motion, providing a simple way to move particles around in a precisely controlled way.

Alfredo Alexander-Katz, the Toyota Career Development Assistant Professor of Materials Science and Engineering, and his doctoral student Charles Sing and other researchers, devised a system that uses tiny beads made of polymers with specks of magnetic material in them. With these beads suspended in a liquid, they applied a rotating magnetic field, which caused the beads to spontaneously form short chains which began spinning, creating currents that could then carry along surrounding particles -- even particles as much as 100 times larger than the beads themselves.

Alexander-Katz refers to the microscopic beads -- each just one micron (a millionth of a meter) in diameter -- as "micro-ants," because of their ability to move along while "carrying" objects so much larger than themselves. A paper describing the research will appear the week of Dec. 14 in the Proceedings of the National Academy of Sciences.

The new method could provide a simpler, less-expensive alternative to present microfluidic devices, a field that is still in its early stages of development. Now, such devices require precisely made channels, valves and pumps created using microchip manufacturing methods, in order to control the movement of fluids through them. But the new system could offer such precise control over the movement of liquids and the particles suspended in them that it may be possible to dispense with the channels and other plumbing altogether, controlling the movements entirely through variations in the applied magnetic field.

In short, software rather than hardware could control the chip's properties, allowing it to be instantly reconfigured through changes in the controlling software -- and approach Alexander-Katz refers to as "virtual microfluidics." This could reduce the cost and increase the flexibility of the devices, which might be used for such things as biomedical screening or the detection of trace elements for pollution monitoring or security screening. It might also provide even finer spatial control than can presently be achieved using conventional channels on chips.

Alexander-Katz says the work might also help biologists better understand the way cilia work, by providing a way to mimic their activity in the lab. "People are still trying to understand how you get synchronization in the system" of cilia in organisms. "This might be a way to test many of the theories."

He says the way the chains of beads moved is a bit like a person trying to do cartwheels while standing on an icy surface. "As they rotate, they slip a bit," he says, "but overall, they keep moving," and this imparts a directional flow to the surrounding fluid.

Ultimately, such a system might someday even be developed to use in medical diagnostics, by allowing controlled delivery of particles inside the body to specifically targeted locations, for example while the patient is in a nuclear magnetic resonance (NMR) imaging system.

Massachusetts Institute of Technology

Related Engineering Articles from Brightsurf:

Re-engineering antibodies for COVID-19
Catholic University of America researcher uses 'in silico' analysis to fast-track passive immunity

Next frontier in bacterial engineering
A new technique overcomes a serious hurdle in the field of bacterial design and engineering.

COVID-19 and the role of tissue engineering
Tissue engineering has a unique set of tools and technologies for developing preventive strategies, diagnostics, and treatments that can play an important role during the ongoing COVID-19 pandemic.

Engineering the meniscus
Damage to the meniscus is common, but there remains an unmet need for improved restorative therapies that can overcome poor healing in the avascular regions.

Artificially engineering the intestine
Short bowel syndrome is a debilitating condition with few treatment options, and these treatments have limited efficacy.

Reverse engineering the fireworks of life
An interdisciplinary team of Princeton researchers has successfully reverse engineered the components and sequence of events that lead to microtubule branching.

New method for engineering metabolic pathways
Two approaches provide a faster way to create enzymes and analyze their reactions, leading to the design of more complex molecules.

Engineering for high-speed devices
A research team from the University of Delaware has developed cutting-edge technology for photonics devices that could enable faster communications between phones and computers.

Breakthrough in blood vessel engineering
Growing functional blood vessel networks is no easy task. Previously, other groups have made networks that span millimeters in size.

Next-gen batteries possible with new engineering approach
Dramatically longer-lasting, faster-charging and safer lithium metal batteries may be possible, according to Penn State research, recently published in Nature Energy.

Read More: Engineering News and Engineering Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.