GSA releases most comprehensive textbook on basic biology of aging to date

December 14, 2015

A new e-book published by The Gerontological Society of America (GSA) provides a primary resource for detailed overviews of the aging process across multiple organisms -- from microbes to humans. This seminal publication, "Molecular and Cellular Biology of Aging," is intended as a textbook for emerging scholars of all levels.

Its contents explore how basic aging processes relate to age-related disease, how aging and longevity are subject to both gene-gene and gene-environment interactions, and how greatly increased insight into these relationships can help scholars design rational strategies for intervention.

The lead editors are Jan Vijg, PhD, of the Albert Einstein College of Medicine; Judith Campisi, PhD, of the Buck Institute for Research on Aging and the Lawrence Berkeley National Laboratory; and Gordon J. Lithgow, PhD, of the Buck Institute for Research on Aging.

"Aging research has undergone a revolution in scientific understanding and potential for meaningful intervention in the last two decades," Campisi said. "Consequently, the field is attracting an unprecedented number of students, new postdoctoral fellows, and accomplished scientists working in other fields."

The book is broken down into ten sections -- with a total of 34 chapters authored by dozens of the world's top scholars in the biological sciences.

"This long-awaited textbook provides the first comprehensive description of modern thinking, experimental results, interpretations and controversies in this growing and fast-evolving field. The e-book format will allow frequent updates, making the textbook a unique and perpetually contemporary guide to the field," Campisi added.

The book begins with an introduction to the science of aging, with a strong focus on its relevance to aging populations and its biological foundations in the evolutionary history of life. It then discusses what is known about aging in intact (mostly model) organisms, and proceeds to focus on ever-finer components of intact organisms: the aging of specific tissues, the cellular bases of aging, age-related changes in subcellular compartments, and finally the aging of biological macromolecules, such as lipids, proteins, and DNA. The final pages offer chapters on the systems biology of aging and possible interventions. Throughout the text, the authors pay special attention to the aging-disease relationship and various theories of aging.

"While not neglecting necessary details, this book focuses on providing insights from basic principles and common characteristics of aging across species," the lead authors state in their introduction. "We firmly believe that deep insight and understanding of solid principles are essential for ultimately developing interventions that might enable us to view aging as we now view disease -- that is, as a condition amenable to treatment."
"Molecular and Cellular Biology of Aging" is available for download at

The Gerontological Society of America (GSA) is the nation's oldest and largest interdisciplinary organization devoted to research, education, and practice in the field of aging. The principal mission of the Society -- and its 5,500+ members -- is to advance the study of aging and disseminate information among scientists, decision makers, and the general public. GSA's structure also includes a policy institute, the National Academy on an Aging Society, and an educational branch, the Association for Gerontology in Higher Education.

The Gerontological Society of America

Related Aging Articles from Brightsurf:

Surprises in 'active' aging
Aging is a process that affects not only living beings.

Aging-US: 'From Causes of Aging to Death from COVID-19' by Mikhail V. Blagosklonny
Aging-US recently published ''From Causes of Aging to Death from COVID-19'' by Blagosklonny et al. which reported that COVID-19 is not deadly early in life, but mortality increases exponentially with age - which is the strongest predictor of mortality.

Understanding the effect of aging on the genome
EPFL scientists have measured the molecular footprint that aging leaves on various mouse and human tissues.

Muscle aging: Stronger for longer
With life expectancy increasing, age-related diseases are also on the rise, including sarcopenia, the loss of muscle mass due to aging.

Aging memories may not be 'worse, 'just 'different'
A study from the Department of Psychological & Brain Sciences in Arts & Sciences adds nuance to the idea that an aging memory is a poor one and finds a potential correlation between the way people process the boundaries of events and episodic memory.

A new biomarker for the aging brain
Researchers at the RIKEN Center for Biosystems Dynamics Research (BDR) in Japan have identified changes in the aging brain related to blood circulation.

Scientists invented an aging vaccine
A new way to prevent autoimmune diseases associated with aging like atherosclerosis, Alzheimer's disease, and Parkinson's disease was described in the article.

The first roadmap for ovarian aging
Infertility likely stems from age-related decline of the ovaries, but the molecular mechanisms that lead to this decline have been unclear.

Researchers discover new cause of cell aging
New research from the USC Viterbi School of Engineering could be key to our understanding of how the aging process works.

Deep Aging Clocks: The emergence of AI-based biomarkers of aging and longevity
The advent of deep biomarkers of aging, longevity and mortality presents a range of non-obvious applications.

Read More: Aging News and Aging Current Events is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to