Nav: Home

GSA releases most comprehensive textbook on basic biology of aging to date

December 14, 2015

A new e-book published by The Gerontological Society of America (GSA) provides a primary resource for detailed overviews of the aging process across multiple organisms -- from microbes to humans. This seminal publication, "Molecular and Cellular Biology of Aging," is intended as a textbook for emerging scholars of all levels.

Its contents explore how basic aging processes relate to age-related disease, how aging and longevity are subject to both gene-gene and gene-environment interactions, and how greatly increased insight into these relationships can help scholars design rational strategies for intervention.

The lead editors are Jan Vijg, PhD, of the Albert Einstein College of Medicine; Judith Campisi, PhD, of the Buck Institute for Research on Aging and the Lawrence Berkeley National Laboratory; and Gordon J. Lithgow, PhD, of the Buck Institute for Research on Aging.

"Aging research has undergone a revolution in scientific understanding and potential for meaningful intervention in the last two decades," Campisi said. "Consequently, the field is attracting an unprecedented number of students, new postdoctoral fellows, and accomplished scientists working in other fields."

The book is broken down into ten sections -- with a total of 34 chapters authored by dozens of the world's top scholars in the biological sciences.

"This long-awaited textbook provides the first comprehensive description of modern thinking, experimental results, interpretations and controversies in this growing and fast-evolving field. The e-book format will allow frequent updates, making the textbook a unique and perpetually contemporary guide to the field," Campisi added.

The book begins with an introduction to the science of aging, with a strong focus on its relevance to aging populations and its biological foundations in the evolutionary history of life. It then discusses what is known about aging in intact (mostly model) organisms, and proceeds to focus on ever-finer components of intact organisms: the aging of specific tissues, the cellular bases of aging, age-related changes in subcellular compartments, and finally the aging of biological macromolecules, such as lipids, proteins, and DNA. The final pages offer chapters on the systems biology of aging and possible interventions. Throughout the text, the authors pay special attention to the aging-disease relationship and various theories of aging.

"While not neglecting necessary details, this book focuses on providing insights from basic principles and common characteristics of aging across species," the lead authors state in their introduction. "We firmly believe that deep insight and understanding of solid principles are essential for ultimately developing interventions that might enable us to view aging as we now view disease -- that is, as a condition amenable to treatment."
"Molecular and Cellular Biology of Aging" is available for download at

The Gerontological Society of America (GSA) is the nation's oldest and largest interdisciplinary organization devoted to research, education, and practice in the field of aging. The principal mission of the Society -- and its 5,500+ members -- is to advance the study of aging and disseminate information among scientists, decision makers, and the general public. GSA's structure also includes a policy institute, the National Academy on an Aging Society, and an educational branch, the Association for Gerontology in Higher Education.

The Gerontological Society of America

Related Aging Articles:

The first roadmap for ovarian aging
Infertility likely stems from age-related decline of the ovaries, but the molecular mechanisms that lead to this decline have been unclear.
Researchers discover new cause of cell aging
New research from the USC Viterbi School of Engineering could be key to our understanding of how the aging process works.
Deep Aging Clocks: The emergence of AI-based biomarkers of aging and longevity
The advent of deep biomarkers of aging, longevity and mortality presents a range of non-obvious applications.
Intelligence can link to health and aging
For over 100 years, scientists have sought to understand what links a person's general intelligence, health and aging.
Putting the brakes on aging
Salk Institute researchers have developed a new gene therapy to help decelerate the aging process.
New insights into the aging brain
A group of scientists at the Gladstone Institutes investigated why the choroid plexus contains so much more klotho than other brain regions.
We all want 'healthy aging,' but what is it, really? New report looks for answers
Led by Paul Mulhausen, MD, MHS, FACP, AGSF, colleagues from the American Geriatrics Society (AGS) set looking critically at what 'healthy aging' really means.
New insight into aging
Researchers at the Montreal Neurological Institute and Hospital (The Neuro) of McGill University examined the effects of aging on neuroplasticity in the primary auditory cortex, the part of the brain that processes auditory information.
Aging may be as old as life itself
Aging has had a bad rap since it has long been considered a consequence of biology's concentrated effort on enhancing survival through reproductivity.
A new link between cancer and aging
Human lung cancer cells resist dying by controlling parts of the aging process, according to findings published online May 10th in the Journal of Biological Chemistry.
More Aging News and Aging Current Events

Trending Science News

Current Coronavirus (COVID-19) News

Top Science Podcasts

We have hand picked the top science podcasts of 2020.
Now Playing: TED Radio Hour

There's so much we've yet to explore–from outer space to the deep ocean to our own brains. This hour, Manoush goes on a journey through those uncharted places, led by TED Science Curator David Biello.
Now Playing: Science for the People

#556 The Power of Friendship
It's 2020 and times are tough. Maybe some of us are learning about social distancing the hard way. Maybe we just are all a little anxious. No matter what, we could probably use a friend. But what is a friend, exactly? And why do we need them so much? This week host Bethany Brookshire speaks with Lydia Denworth, author of the new book "Friendship: The Evolution, Biology, and Extraordinary Power of Life's Fundamental Bond". This episode is hosted by Bethany Brookshire, science writer from Science News.
Now Playing: Radiolab

Dispatch 1: Numbers
In a recent Radiolab group huddle, with coronavirus unraveling around us, the team found themselves grappling with all the numbers connected to COVID-19. Our new found 6 foot bubbles of personal space. Three percent mortality rate (or 1, or 2, or 4). 7,000 cases (now, much much more). So in the wake of that meeting, we reflect on the onslaught of numbers - what they reveal, and what they hide.  Support Radiolab today at