Nav: Home

Jneurosci: Highlights from the Dec. 14 issue

December 14, 2016

Check out these newsworthy studies from the Dec. 14, 2016, issue of JNeurosci. Media interested in obtaining the full text of the studies should contact media@sfn.org.

Working Memory Decline Linked to Loss of Specific Receptor in Rats

Working memory, the ability to hold a piece of information in mind for a short time, is essential to general cognitive ability and often deteriorates as we get older. Previous studies implicate receptors for the neurotransmitter glutamate in working memory function. In a new study in rats, researchers find glutamate receptors containing a specific protein subunit are required for working memory, with the loss of these receptors linked to working memory impairments. The results suggest therapies to precisely target these receptors may help improve working memory in older adults.

Corresponding author: Jennifer Bizon, bizonj@ufl.edu

Two-Way Communication Between Brain and Blood Vessels

An increase in brain activity triggers an increase in blood flow, ensuring a steady supply of oxygen and energy to the brain. In a new study using brain tissue from mice and rats, researchers find the communication between the brain and blood vessels is a two-way street during normal, resting conditions. Increases in blood pressure constrict blood vessels and diminish the baseline rate of neural firing, while decreases in blood pressure increase neural firing. The researchers propose this is a neuroprotective strategy, enabling neurons to adjust their baseline activity so they don't exhaust energy supplies.

Corresponding author: Jessica Filosa, jfilosa@augusta.edu

Receptor Targeted to Treat Insulin Resistance Also Involved in Stress Response

Pioglitazone, a drug used to treat type 2 diabetes, attenuates insulin resistance by binding to specific cellular receptors. Recent evidence indicates these receptors -- called peroxisome proliferator-activated receptor gamma, or PPAR-gamma -- may help regulate immune function in the central nervous system. In a new study, researchers find the receptors also play a role in the stress response: stimulating the receptors with pioglitazone reduced stress-induced anxiety in mice. The results suggest treatments stimulating PPAR-gamma may be beneficial for stress and anxiety disorders.

Corresponding author: Roberto Ciccocioppo, roberto.ciccocioppo@unicam.it
-end-
The Journal of Neuroscience is published by the Society for Neuroscience, an organization of nearly 38,000 basic scientists and clinicians who study the brain and nervous system.

Society for Neuroscience

Related Diabetes Articles:

Tele-diabetes to manage new-onset diabetes during COVID-19 pandemic
Two new case studies highlight the use of tele-diabetes to manage new-onset type 1 diabetes in an adult and an infant during the COVID-19 pandemic.
Genetic profile may predict type 2 diabetes risk among women with gestational diabetes
Women who go on to develop type 2 diabetes after having gestational, or pregnancy-related, diabetes are more likely to have particular genetic profiles, suggests an analysis by researchers at the National Institutes of Health and other institutions.
Maternal gestational diabetes linked to diabetes in children
Children and youth of mothers who had gestational diabetes during pregnancy are at increased risk of diabetes themselves, according to new research published in CMAJ (Canadian Medical Association Journal).
Two diabetes medications don't slow progression of type 2 diabetes in youth
In youth with impaired glucose tolerance or recent-onset type 2 diabetes, neither initial treatment with long-acting insulin followed by the drug metformin, nor metformin alone preserved the body's ability to make insulin, according to results published online June 25 in Diabetes Care.
People with diabetes visit the dentist less frequently despite link between diabetes, oral health
Adults with diabetes are less likely to visit the dentist than people with prediabetes or without diabetes, finds a new study led by researchers at NYU Rory Meyers College of Nursing and East Carolina University's Brody School of Medicine.
Diabetes, but not diabetes drug, linked to poor pregnancy outcomes
New research indicates that pregnant women with pre-gestational diabetes who take metformin are at a higher risk for adverse pregnancy outcomes -- such as major birth defects and pregnancy loss -- than the general population, but their increased risk is not due to metformin but diabetes.
New oral diabetes drug shows promise in phase 3 trial for patients with type 1 diabetes
A University of Colorado Anschutz Medical Campus study finds sotagliflozin helps control glucose and reduces the need for insulin in patients with type 1 diabetes.
Can continuous glucose monitoring improve diabetes control in patients with type 1 diabetes who inject insulin
Two studies in the Jan. 24/31 issue of JAMA find that use of a sensor implanted under the skin that continuously monitors glucose levels resulted in improved levels in patients with type 1 diabetes who inject insulin multiple times a day, compared to conventional treatment.
Complications of type 2 diabetes affect quality of life, care can lead to diabetes burnout
T2D Lifestyle, a national survey by Health Union of more than 400 individuals experiencing type 2 diabetes (T2D), reveals that patients not only struggle with commonly understood complications, but also numerous lesser known ones that people do not associate with diabetes.
A better way to predict diabetes
An international team of researchers has discovered a simple, accurate new way to predict which women with gestational diabetes will develop type 2 diabetes after delivery.
More Diabetes News and Diabetes Current Events

Trending Science News

Current Coronavirus (COVID-19) News

Top Science Podcasts

We have hand picked the top science podcasts of 2020.
Now Playing: TED Radio Hour

Climate Mindset
In the past few months, human beings have come together to fight a global threat. This hour, TED speakers explore how our response can be the catalyst to fight another global crisis: climate change. Guests include political strategist Tom Rivett-Carnac, diplomat Christiana Figueres, climate justice activist Xiye Bastida, and writer, illustrator, and artist Oliver Jeffers.
Now Playing: Science for the People

#562 Superbug to Bedside
By now we're all good and scared about antibiotic resistance, one of the many things coming to get us all. But there's good news, sort of. News antibiotics are coming out! How do they get tested? What does that kind of a trial look like and how does it happen? Host Bethany Brookeshire talks with Matt McCarthy, author of "Superbugs: The Race to Stop an Epidemic", about the ins and outs of testing a new antibiotic in the hospital.
Now Playing: Radiolab

Speedy Beet
There are few musical moments more well-worn than the first four notes of Beethoven's Fifth Symphony. But in this short, we find out that Beethoven might have made a last-ditch effort to keep his music from ever feeling familiar, to keep pushing his listeners to a kind of psychological limit. Big thanks to our Brooklyn Philharmonic musicians: Deborah Buck and Suzy Perelman on violin, Arash Amini on cello, and Ah Ling Neu on viola. And check out The First Four Notes, Matthew Guerrieri's book on Beethoven's Fifth. Support Radiolab today at Radiolab.org/donate.