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Hormone-disrupting compound could provide new approach to malaria control

December 15, 2016

Boston, MA - A chemical that disrupts biological processes in female mosquitoes may be just as effective as insecticides in reducing the spread of malaria, according to a new study from Harvard T.H. Chan School of Public Health.

The study will be published online December 15, 2016 in PLOS Pathogens.

"As insecticide resistance is spreading, new intervention methods to control mosquitoes are urgently needed," said Flaminia Catteruccia, associate professor of immunology and infectious diseases at Harvard Chan School and co-senior author of the study. "Our study provides a new strategy based on the use of a non-toxic compound that prevents transmission of malaria parasites without killing the mosquito."

Malaria kills about 500,000 people every year. People can become infected when bitten by mosquitoes carrying the malaria parasite, Plasmodium falciparum. Typical strategies to prevent transmission involve the use of insecticide-treated bed nets and insecticide spraying, but Anopheles mosquitoes--the type that transmits P. falciparum parasites--are rapidly becoming resistant to insecticides.

In the new study, researchers treated Anopheles female mosquitoes with a synthetic chemical called DBH (dibenzoylhydrazine) to see how it would impact their biological processes. DBH mimics the action of the steroid hormone "20E" (20-hydroxyecdysone), which plays a key role in the reproductive cycle of the female mosquito.

Various aspects of the mosquitoes' life cycle were disrupted after treatment with DBH, the researchers found. The females produced and laid fewer eggs; they didn't mate successfully; and they died more rapidly than non-treated mosquitoes. The effects were greater the higher the DBH dose. DBH-treated mosquitoes were also less likely to be infected by malaria parasites.

Using DBH in either bed nets or in sprays was equally effective, the researchers found. They also noted that DBH compounds are not toxic to mammals, which would make them ideally suited for use in bed nets, where low toxicity is essential.

"The study demonstrates the importance of basic research on mosquito biology for developing new tools against malaria," said Caroline Buckee, co-senior author and assistant professor of epidemiology at Harvard Chan School.
Co-lead authors of the study were Harvard Chan School researchers Lauren Childs, Francisco Cai, and Evdoxia Kakani. Other Harvard Chan authors included Sara Mitchell, Doug Paton, and Paolo Gabrieli.

The study was partially supported by the Bill & Melinda Gates Foundation (Grant ID: OPP1140143).

"Disrupting mosquito reproduction and parasite development for malaria control," Lauren M. Childs, Francisco Y. Cai, Evdoxia G. Kakani, Sara N. Mitchell, Doug Paton, Paolo Gabrieli, Caroline O. Buckee, Flaminia Catteruccia, PLOS Pathogens, online December 15, 2016, doi: 10.1371/journal.ppat.1006060

Visit the Harvard Chan School website for the latest news, press releases, and multimedia offerings.

Harvard T.H. Chan School of Public Health brings together dedicated experts from many disciplines to educate new generations of global health leaders and produce powerful ideas that improve the lives and health of people everywhere. As a community of leading scientists, educators, and students, we work together to take innovative ideas from the laboratory to people's lives--not only making scientific breakthroughs, but also working to change individual behaviors, public policies, and health care practices. Each year, more than 400 faculty members at Harvard Chan School teach 1,000-plus full-time students from around the world and train thousands more through online and executive education courses. Founded in 1913 as the Harvard-MIT School of Health Officers, the School is recognized as America's oldest professional training program in public health.

Harvard T.H. Chan School of Public Health

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