UCSD bioinformatics researcher studies tumor genome architectures with career award

December 16, 2004

Postdoctoral researcher Benjamin Raphael is one of only eleven scientists nationwide honored by the Burroughs Wellcome Fund (BWF) for work at the intersection of computer science, mathematics, and biology. The mathematician and computer scientist from the University of California, San Diego's Jacobs School of Engineering will receive $500,000 over five years from BWF to support his research in the area of high-resolution analysis of tumor genome architectures. Raphael works in the Computer Science and Engineering (CSE) department's Bioinformatics Laboratory, led by CSE professor Pavel Pevzner.

One of five different BWF award programs, the Career Award at the Scientific Interface (CASI) is awarded by the North Carolina-based fund to support physical or computational scientists conducting biological research. Awards to this year's winners totaled $5.4 million, and the fund has invested roughly $13 million in the program since its inception in 2002. The awards are typically designed to bridge advanced postdoctoral training and the early years of faculty service. "This award is extremely important to me because it comes at a critical time in my career," said Raphael, who co-organized a conference on regulatory genomics at UCSD earlier this year, co-sponsored by the California Institute for Telecommunications and Information Technology [Cal-(IT)2] .

In a sense, Raphael says, he has come full circle. The Virginia-bred researcher majored in mathematics and biology as an undergraduate at MIT. Raphael then came to UCSD to earn his doctorate in mathematics. "Towards the end of my Ph.D. studies," he said, "I wanted to do something more applied, and bioinformatics was an exciting area." Raphael was awarded an Alfred P. Sloan Fellowship in 2002 because, he says, "the Foundation recognized the need for quantitative Ph.D.'s to work in biology."

The 30-year-old researcher works at the cutting-edge of genomic science - and health. His work began with an analysis of regulatory sites in the mouse genome that others in Pevzner's lab were analyzing for their evolutionary implications, including genome rearrangements that account for the different paths humans and rodents have taken since splitting off from a common ancestor roughly 87 million years ago. These rearrangements "happen in cancer naturally," Raphael notes, adding that "by studying the rearrangements we can identify genes that are important for tumor growth, development and malignancy, and these may serve as diagnostics of tumor stages."

Raphael's work in cancer genomics began in late 2002, when Colin Collins and Stas Volik, experimental biologists at the University of California, San Francisco (UCSF) Cancer Center, sought out Pevzner's group to do computational analysis of genome rearrangements implicated in breast cancer. "You can view the breast cancer genome as an extremely fast-evolving human genome," says Pevzner. "Now that the human genome has been sequenced, we can do the same for specific cancer cells, not just any cell in the body."

"We are up to five tumor genomes that we study, including the genomes for prostate cancer, brain tumors, and so on," Raphael adds. "We are looking at rearrangements that are common to certain cell types, and the work is accelerating because the public is putting pressure on science agencies to fund cancer research."

Raphael and Pevzner hope to team with the UCSF Cancer Center on a Tumor Genome Project. "The idea is that there is all this sequencing capacity left over from decoding the human, mouse, rat, chicken and other genomes," said Raphael. "Public funding agencies will now be under pressure to support sequencing efforts that are important medically. Sequencing tumor genomes helps us to understand better how tumors behave and progress."

Pevzner and Raphael have also held discussions about the Tumor Genome Project with UCSD Cancer Center director Dennis Carson, and Richard Kolodner, a member of UCSD's Ludwig Institute for Cancer Research. Both lent their support to BWF's awards committee on Raphael's behalf.

"Cancer in a sense is a breakdown of DNA repair, and the rearrangements that we see are unrepaired mistakes in the process of DNA replication," adds Raphael. "There are whole classes of genetic diseases that are inherited and passed down from a parent. Mutations in our DNA can be single-letter changes like those that occur in cystic fibrosis, or they can involve multiple chromosomal rearrangements such as those associated with solid tumors."

Raphael was planning to apply for a faculty position this year, but says the BWF award will afford him an easier transition. "I now have a little more freedom to do research and stay here at least one more year," he explains. "I plan to apply for a faculty appointment in 2006." His future destination is unclear: "Depending on the university, bioinformatics work is happening in the computer science department, math department, biology department, or in an interdisciplinary center." Raphael says that he favors teaching in a quantitative department but wants to maintain close ties with biological researchers.

"I think this award shows UCSD is a great environment for doing work at the intersection of biological sciences, quantitative mathematics and computer science," says Raphael. "It is an award for UCSD, not just for me."
-end-
Related Links

Burroughs Wellcome Fund www.bwfund.org
UCSD Cancer Center http://cancer.ucsd.edu
Ludwig Institute for Cancer Research at UCSD http://ludwig.ucsd.edu
Ben Raphael Website www.cs.ucsd.edu/~braphael/

"Reconstructing Tumor Amplisomes," by Ben Raphael and Pavel Pevzner, Bioinformatics, August 2004
http://bioinformatics.oupjournals.org/cgi/content/abstract/20/suppl_1/i265

University of California - San Diego

Related Breast Cancer Articles from Brightsurf:

Oncotarget: IGF2 expression in breast cancer tumors and in breast cancer cells
The Oncotarget authors propose that methylation of DVDMR represents a novel epigenetic biomarker that determines the levels of IGF2 protein expression in breast cancer.

Breast cancer: AI predicts which pre-malignant breast lesions will progress to advanced cancer
New research at Case Western Reserve University in Cleveland, Ohio, could help better determine which patients diagnosed with the pre-malignant breast cancer commonly as stage 0 are likely to progress to invasive breast cancer and therefore might benefit from additional therapy over and above surgery alone.

Partial breast irradiation effective treatment option for low-risk breast cancer
Partial breast irradiation produces similar long-term survival rates and risk for recurrence compared with whole breast irradiation for many women with low-risk, early stage breast cancer, according to new clinical data from a national clinical trial involving researchers from The Ohio State University Comprehensive Cancer Center - Arthur G.

Breast screening linked to 60 per cent lower risk of breast cancer death in first 10 years
Women who take part in breast screening have a significantly greater benefit from treatments than those who are not screened, according to a study of more than 50,000 women.

More clues revealed in link between normal breast changes and invasive breast cancer
A research team, led by investigators from Georgetown Lombardi Comprehensive Cancer Center, details how a natural and dramatic process -- changes in mammary glands to accommodate breastfeeding -- uses a molecular process believed to contribute to survival of pre-malignant breast cells.

Breast tissue tumor suppressor PTEN: A potential Achilles heel for breast cancer cells
A highly collaborative team of researchers at the Medical University of South Carolina and Ohio State University report in Nature Communications that they have identified a novel pathway for connective tissue PTEN in breast cancer cell response to radiotherapy.

Computers equal radiologists in assessing breast density and associated breast cancer risk
Automated breast-density evaluation was just as accurate in predicting women's risk of breast cancer, found and not found by mammography, as subjective evaluation done by radiologists, in a study led by researchers at UC San Francisco and Mayo Clinic.

Blood test can effectively rule out breast cancer, regardless of breast density
A new study published in PLOS ONE demonstrates that Videssa® Breast, a multi-protein biomarker blood test for breast cancer, is unaffected by breast density and can reliably rule out breast cancer in women with both dense and non-dense breast tissue.

Study shows influence of surgeons on likelihood of removal of healthy breast after breast cancer dia
Attending surgeons can have a strong influence on whether a patient undergoes contralateral prophylactic mastectomy after a diagnosis of breast cancer, according to a study published by JAMA Surgery.

Young breast cancer patients undergoing breast conserving surgery see improved prognosis
A new analysis indicates that breast cancer prognoses have improved over time in young women treated with breast conserving surgery.

Read More: Breast Cancer News and Breast Cancer Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.