Bacteria wouldn't opt for a swine flu shot

December 16, 2009

Bacteria inhabited our planet for more than 4 billion years before humans showed up, and they'll probably outlive us by as many eons more. That suggests they may have something to teach us.

New research from Tel Aviv University bacteria expert Prof. Eshel Ben-Jacob of the Raymond and Beverly Sackler School of Physics and Astronomy, grounded in the study of bacteria, presents compelling evidence to suggest there may be good reasons why most people should not automatically opt for the swine flu H1N1 shot.

In research published in the Proceedings of the National Academy of Sciences (PNAS), Prof. Ben Jacob uses the decision-making of bacteria, an analogue of "game theory," as a model to make his case.

"Unlike our health authorities, bacteria would never panic," he says. "Bacteria don't follow the media or watch cable news. Instead, they send chemical messages to each other -- in a colony 100 times larger than the earth's human population -- to make their decisions. And based on what we've seen in bacterial colonies, I know they would be suspicious committing to swine flu shots. They wouldn't opt for a colony wide vaccination," Prof. Ben Jacob concludes.

The prisoner's dilemma

The new research, done in collaboration with Dr. Daniel Schultz, a postdoctoral fellow at TAU, and Profs. José Onuchic and Peter Wolynes at the University of California/San Diego, not only provides a paradigm for assessing responses to health emergencies, it may also provide investors with insight into how to manage stock portfolios.

In the PNAS paper, the scientists explored how microscopic creatures living in large colonies decide their fate in adverse times under complicated and life threatening conditions. They found that bacteria communicate through chemical signals and reach decisions in sophisticated ways, using an elaborate network of genes and proteins to calculate complex possibilities, as in "game theory."

In essence, in life or death situations, bacteria employ more advanced tactics than those used to solve the classic problem known as "the prisoner's dilemma." This may account for their colony's resilience. In the classic problem, two prisoners are asked to betray each other. If one testifies against the other and the other remains silent, the betrayer goes free and the silent one (the prisoner loyal to his friend), will get 10 years in prison. If both remain silent (and cooperate with each other), they are sentenced to only one year in jail. If each one betrays the other, both will be sentenced to 5 years in jail. The temptation, of course, is to betray -- but neither prisoner can be sure what the other will say, and could risk five years in jail.

In the case of bacteria, there are not two but hundreds of billions of participants with a limited time to decide whether to deal with a stress situation by all turning into spores. Each bacterium has to decide whether it will cooperate or not. Unlike the prisoners, there is a clock ticking away. And each bacterium must quickly send out chemical messages to its peer cells about its intentions.

Bacteria "usually don't lie" about their own plans, Prof. Ben Jacob says, but the minority that do have a chance of surviving won't cheat to postpone the decision of others. The scientists' new article presents a model that decodes how bacteria use the gene-and-protein networks to calculate risks and the game theory principles they employ.

Maintaining a delicate balance

Americans uncertain about getting the H1N1 flu shot because they've heard about potentially dangerous side effects also face the prisoner's dilemma. Perhaps it's better not to get the shot, one may think, because if everybody else is vaccinated, the virus will be wiped out before it reaches me.

"The simple rule we learned from bacteria is that anybody who has to make an important decision -- especially one of life and death at times of stress -- should wait to see the trend of changes, process the risks and odds in depth, and only then decide," says Prof. Ben-Jacob.

Based on what he and his colleagues learned about bacteria, he imagines that bacteria might offer this counsel regarding the flu shot: "They might suggest that only people who have widespread and intense contact with many others, such as business travellers and teachers, should get the shot. Those who are most likely to spread the virus should be vaccinated.

"Bacteria don't take risks like we do and the results have paid off. They are super-successful, more than any creature on earth. They wouldn't abuse the stock market, and would never invest beyond their means. I am also pretty sure most would not rush to get the flu shot, if given the choice," he concludes. "They know how to keep a delicate balance."
-end-
American Friends of Tel Aviv University (www.aftau.org) supports Israel's leading and most comprehensive center of higher learning. In independent rankings, TAU's innovations and discoveries are cited more often by the global scientific community than all but 20 other universities worldwide.

Internationally recognized for the scope and groundbreaking nature of its research programs, Tel Aviv University consistently produces work with profound implications for the future.

American Friends of Tel Aviv University

Related Bacteria Articles from Brightsurf:

Siblings can also differ from one another in bacteria
A research team from the University of Tübingen and the German Center for Infection Research (DZIF) is investigating how pathogens influence the immune response of their host with genetic variation.

How bacteria fertilize soya
Soya and clover have their very own fertiliser factories in their roots, where bacteria manufacture ammonium, which is crucial for plant growth.

Bacteria might help other bacteria to tolerate antibiotics better
A new paper by the Dynamical Systems Biology lab at UPF shows that the response by bacteria to antibiotics may depend on other species of bacteria they live with, in such a way that some bacteria may make others more tolerant to antibiotics.

Two-faced bacteria
The gut microbiome, which is a collection of numerous beneficial bacteria species, is key to our overall well-being and good health.

Microcensus in bacteria
Bacillus subtilis can determine proportions of different groups within a mixed population.

Right beneath the skin we all have the same bacteria
In the dermis skin layer, the same bacteria are found across age and gender.

Bacteria must be 'stressed out' to divide
Bacterial cell division is controlled by both enzymatic activity and mechanical forces, which work together to control its timing and location, a new study from EPFL finds.

How bees live with bacteria
More than 90 percent of all bee species are not organized in colonies, but fight their way through life alone.

The bacteria building your baby
Australian researchers have laid to rest a longstanding controversy: is the womb sterile?

Hopping bacteria
Scientists have long known that key models of bacterial movement in real-world conditions are flawed.

Read More: Bacteria News and Bacteria Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.