Brigham and Women's Hospital receives a $140 million NIH grant to fund the AIDS Clinical Trial Group

December 16, 2013

Boston, MA-- The National Institute of Allergy and Infectious Diseases (NIAID) has awarded two seven-year grants to Brigham and Women's Hospital (BWH) to fund the AIDS Clinical Trial Group (ACTG) Network. The grants support the ACTG's Leadership and Operations Center (LOC) and Laboratory Center (LC). The funding totals $20 million annually or $140 million over seven years.

"The work accomplished by the ACTG over the last quarter century has had a profound impact on the wellbeing of persons living with HIV/AIDS, tuberculosis and viral hepatitis," said Daniel Kuritzkes, MD, chief of the Division of Infectious Diseases at BWH, principal investigator and chair of the ACTG.. "Results of ACTG trials have helped establish the paradigm for the management of HIV disease and form the basis of current treatment guidelines in the US and internationally. This progress has resulted in dramatic reductions in AIDS mortality across the globe. These accomplishments have been accelerated by an innovative alliance of academic, government and industry scientists, clinicians, regulatory agencies and community advocates. We are delighted that NIAID has provided us the opportunity to continue this important work over the next seven years."

The ACTG is an international consortium of clinical research sites conducting clinical trials in HIV-infected adults to test novel therapeutic interventions focused on HIV-associated inflammation and resulting end-organ disease, tuberculosis, viral hepatitis and HIV cure.

The continued funding underscores how Ed Perlmutter, 65, an ACTG study participant, feels about the importance of this work. Perlmutter joined the ACTG in 2006 when he was diagnosed with HIV.

"The first study I participated in helped to determine what antiretroviral drugs worked best in my patient population. I knew, after that study ended, that I directly helped other people with HIV determine what drugs would be best for them," he explained.

The ACTG has had many achievements over the years, some highlights include: enrolling more than 25,000 participants into 85 clinical trials in the US and in resource-limited settings around the world, developing a laboratory infrastructure to conduct clinical trials of TB and multidrug-resistant (MDR) TB in resource-limited settings, conducting trials comparing various antiretroviral drug regimens that form the cornerstones of current guidelines and standards of clinical management of HIV-1 infection, proving that early initiation of antiretroviral therapy (ART) in patients starting treatment for tuberculosis improves survival in patients with advanced AIDS, and many more.

Approximately 50 Clinical Research Sites (CRS) domestically and internationally will receive additional funding from NIAID to conduct trials designed and implemented by the ACTG investigators and collaborators from around the world. The international CRSs are located primarily in resource-limited settings, including the Caribbean, South America, Africa and Asia.
For more information about the ACTG visit

The AIDS Clinical Trials Group (ACTG) Network's Leadership and Operations Center (LOC) and Laboratory Center (LC) are based at Brigham and Women's Hospital in Boston. The ACTG Network's mission is to develop and conduct scientifically rigorous translational research and clinical trials to (1) investigate the viral and immune pathogenesis of HIV-1 infection and its complications; (2) evaluate novel drugs and strategies for treating HIV-1 infection; (3) evaluate interventions and strategies to treat and prevent HIV-related co-infections and co-morbidity, and; (4) publish and disseminate results to improve care, and reduce or eliminate morbidity and mortality associated with HIV-1 infection and its complications. The Network has 60 research sites around the world.

Brigham and Women's Hospital (BWH) is a 793-bed nonprofit teaching affiliate of Harvard Medical School and a founding member of Partners HealthCare. BWH has more than 3.5 million annual patient visits, is the largest birthing center in New England and employs nearly 15,000 people. The Brigham's medical preeminence dates back to 1832, and today that rich history in clinical care is coupled with its national leadership in patient care, quality improvement and patient safety initiatives, and its dedication to research, innovation, community engagement and educating and training the next generation of health care professionals. Through investigation and discovery conducted at its Biomedical Research Institute (BRI), BWH is an international leader in basic, clinical and translational research on human diseases, more than 1,000 physician-investigators and renowned biomedical scientists and faculty supported by nearly $650 million in funding. For the last 25 years, BWH ranked second in research funding from the National Institutes of Health (NIH) among independent hospitals. BWH continually pushes the boundaries of medicine, including building on its legacy in transplantation by performing a partial face transplant in 2009 and the nation's first full face transplant in 2011. BWH is also home to major landmark epidemiologic population studies, including the Nurses' and Physicians' Health Studies and the Women's Health Initiative. For more information and resources, please visit BWH's online newsroom.

Brigham and Women's Hospital

Related Tuberculosis Articles from Brightsurf:

Scientists find new way to kill tuberculosis
Scientists have discovered a new way of killing the bacteria that cause tuberculosis (TB), using a toxin produced by the germ itself.

Blocking the iron transport could stop tuberculosis
The bacteria that cause tuberculosis need iron to survive. Researchers at the University of Zurich have now solved the first detailed structure of the transport protein responsible for the iron supply.

Tuberculosis: New insights into the pathogen
Researchers at the University of W├╝rzburg and the Spanish Cancer Research Centre have gained new insights into the pathogen that causes tuberculosis.

Unmasking the hidden burden of tuberculosis in Mozambique
The real burden of tuberculosis is probably higher than estimated, according to a study on samples from autopsies performed in a Mozambican hospital.

HIV/tuberculosis co-infection: Tunneling towards better diagnosis
1.2 million people in the world are co-infected by the bacteria which causes tuberculosis and AIDS.

Reducing the burden of tuberculosis treatment
A research team led by MIT has developed a device that can lodge in the stomach and deliver antibiotics to treat tuberculosis, which they hope will make it easier to cure more patients and reduce health care costs.

Tuberculosis: Commandeering a bacterial 'suicide' mechanism
The bacteria responsible for tuberculosis can be killed by a toxin they produce unless it is neutralized by an antidote protein.

A copper bullet for tuberculosis
Tuberculosis is a sneaky disease, and the number one cause of death from infectious disease worldwide.

How damaging immune cells develop during tuberculosis
Insights into how harmful white blood cells form during tuberculosis infection point to novel targets for pharmacological interventions, according to a study published in the open-access journal PLOS Pathogens by Valentina Guerrini and Maria Laura Gennaro of Rutgers New Jersey Medical School, and colleagues.

How many people die from tuberculosis every year?
The estimates for global tuberculosis deaths by the World Health Organisation (WHO) and the Institute for Health Metrics and Evaluation (IHME) differ considerably for a dozen countries, according to a study led by ISGlobal.

Read More: Tuberculosis News and Tuberculosis Current Events is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to