Weight loss through diet changes can improve sleep at any body weight, says Penn study

December 16, 2015

For Immediate Release

PHILADELPHIA -- Weight loss due to dietary changes can improve sleepiness at any weight, says a study published by researchers from the Perelman School of Medicine at the University of Pennsylvania this month in the journal Sleep. The findings offer new insights into how weight fluctuations impact numerous aspects of sleep independent of body weight.

Previous studies have linked obesity with persistent sleepiness, lack of energy during the day, and poor sleep quality, all of which can be successfully combatted with weight loss treatment. But until now, researchers have known little about the link between excessive weight, poor dietary habits, and sleep/wake abnormalities.

Nearly 185 million adults and 24 million children in the United States are overweight or obese. In Philadelphia, an estimated 68 percent of adults are overweight or obese. Beyond impaired cognitive function, poor sleep is associated with a host of chronic health problems including depression, obesity, and hypertension. Additionally, the Centers for Disease Control and Prevention estimates that 50 to 70 million U.S. adults experience sleep or wakefulness disorders.

In the current research, obesity was studied using diet-induced obese mice. Half the mice were randomly chosen to receive regular chow (RC) while the other mice were fed a high-fat diet (HFD, more than three times higher in fat content) for eight weeks. At the end of that period, some of the mice were switched to the alternative diet for one week, causing newly-fed HFD mice to gain weight and newly-fed RC mice to lose weight, while the rest of the mice continued to consume their current diet.

After the ninth week, mice maintained on HFD weighed 30 percent more, slept more than one hour longer per day, and suffered from increased wake fragmentation (frequently slipping into sleep) compared to mice maintained on RC. The "diet switch" groups, however, had similar body weight at week nine, but completely different sleep/wake profiles when compared to each other.

"Our findings suggest body weight is a less important factor than changes in weight for regulating sleepiness," said the study's lead author, Isaac Perron, a PhD student in Neuroscience at the University of Pennsylvania. "Diet-induced obese mice that ate a regular chow diet for only one week showed the same sleep/wake profile as mice that ate a regular chow diet for nine weeks."

The findings have implications for the lean population as well, since mice consuming the low-fat diet for eight weeks followed by only one week of HFD had similar sleep as those eating a HFD for nine weeks.

"The diet consumed during the final week was key to driving the sleep effects, independent of the starting body weight," said Perron. "If you're overweight and often feel tired, you may not need to lose all the weight to improve sleep, but rather just beginning to lose that excess weight may improve your sleep abnormalities and wake impairments."

As individuals pursue these dietary changes, they may start to feel more awake during the day and be motivated to live a healthier lifestyle.

"This study has mapped a completely novel food and sleep interaction," said co-author Sigrid Veasey, MD, DABSM, a professor in the division of Sleep Medicine and a member of Penn's Center for Sleep and Circadian Neurobiology.

"That changing to a healthier diet can acutely improve alertness and sleep, is extremely important and certainly an interaction to now test in humans."

Allan I. Pack, also from Penn, is a co-author on the study.
-end-
The work was funded by the T32 Sleep Training Grant (HL07953) and Research Program Project Grant (P01-AG017628).

Penn Medicine is one of the world's leading academic medical centers, dedicated to the related missions of medical education, biomedical research, and excellence in patient care. Penn Medicine consists of the Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania (founded in 1765 as the nation's first medical school) and the University of Pennsylvania Health System, which together form a $5.3 billion enterprise.

The Perelman School of Medicine has been ranked among the top five medical schools in the United States for the past 17 years, according to U.S. News & World Report's survey of research-oriented medical schools. The School is consistently among the nation's top recipients of funding from the National Institutes of Health, with $409 million awarded in the 2014 fiscal year.

The University of Pennsylvania Health System's patient care facilities include: The Hospital of the University of Pennsylvania -- recognized as one of the nation's top "Honor Roll" hospitals by U.S. News & World Report; Penn Presbyterian Medical Center; Chester County Hospital; Penn Wissahickon Hospice; and Pennsylvania Hospital -- the nation's first hospital, founded in 1751. Additional affiliated inpatient care facilities and services throughout the Philadelphia region include Chestnut Hill Hospital and Good Shepherd Penn Partners, a partnership between Good Shepherd Rehabilitation Network and Penn Medicine.

Penn Medicine is committed to improving lives and health through a variety of community-based programs and activities. In fiscal year 2014, Penn Medicine provided $771 million to benefit our community.

University of Pennsylvania School of Medicine

Related Obesity Articles from Brightsurf:

11 years of data add to the evidence for using testosterone therapy to treat obesity, including as an alternative to obesity surgery
New research covering 11 years of data presented at this year's European and International Congress on Obesity (ECOICO 2020) show that, in obese men suffering from hypogonadism (low testosterone), treatment with testosterone injections lowers their weight and improves a wide range of other metabolic parameters.

Overlap between immunology of COVID-19 and obesity could explain the increased risk of death in people living with obesity, and also older patients
Data presented in a special COVID-19 session at the European and International Congress on Obesity (ECOICO 2020) suggests that there are overlaps between the immunological disturbances found in both COVID-19 disease and patients with obesity, which could explain the increased disease severity and mortality risk faced by obese patients, and also elderly patients, who are infected by the SARS-CoV-2 virus that causes COVID-19 disease.

New obesity guideline: Address root causes as foundation of obesity management
besity management should focus on outcomes that patients consider to be important, not weight loss alone, and include a holistic approach that addresses the root causes of obesity, according to a new clinical practice guideline published in CMAJ (Canadian Medical Association Journal) http://www.cmaj.ca/lookup/doi/10.1503/cmaj.191707.

Changing the debate around obesity
The UK's National Health Service (NHS) needs to do more to address the ingrained stigma and discrimination faced by people with obesity, says a leading health psychologist.

Study links longer exposure to obesity and earlier development of obesity to increased risk of type 2 diabetes
Cumulative exposure to obesity could be at least as important as actually being obese in terms of risk of developing type 2 diabetes (T2D), concludes new research published in Diabetologia (the journal of the European Association for the Study of Diabetes [EASD]).

How much do obesity and addictions overlap?
A large analysis of personality studies has found that people with obesity behave somewhat like people with addictions to alcohol or drugs.

Should obesity be recognized as a disease?
With obesity now affecting almost a third (29%) of the population in England, and expected to rise to 35% by 2030, should we now recognize it as a disease?

Is obesity associated with risk of pediatric MS?
A single-center study of 453 children in Germany with multiple sclerosis (MS) investigated the association of obesity with pediatric MS risk and with the response of first-line therapy in children with MS.

Women with obesity prior to conception are more likely to have children with obesity
A systematic review and meta-analysis identified significantly increased odds of child obesity when mothers have obesity before conception, according to a study published June 11, 2019 in the open-access journal PLOS Medicine by Nicola Heslehurst of Newcastle University in the UK, and colleagues.

Obesity medicine association announces major updates to its adult obesity algorithm
The Obesity Medicine Association (OMA) announced the immediate availability of the 2019 OMA Adult Obesity Algorithm, with new information for clinicians including the relationship between Obesity and Cardiovascular Disease, Diabetes Mellitus, Dyslipidemia, and Cancer; information on investigational Anti-Obesity Pharmacotherapy; treatments for Lipodystrophy; and Pharmacokinetics and Obesity.

Read More: Obesity News and Obesity Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.