Survivors of childhood Hodgkin lymphoma face high long-term risk of solid cancers

December 17, 2018

New research refines existing evidence that survivors of childhood Hodgkin lymphoma face an elevated risk of developing various types of solid tumors many years later. In addition, certain subgroups of patients have an especially high risk. Published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the findings may help refine guidelines for cancer screening in Hodgkin lymphoma survivors.

It's known that survivors of Hodgkin lymphoma--a cancer that starts in cells called lymphocytes--during childhood have an increased risk of developing additional forms of cancer, including solid cancers, but the magnitude of this risk over the long term is unknown.

To investigate, Smita Bhatia, MD, MPH, of the University of Alabama at Birmingham, and her colleagues analyzed information on 1,136 patients who were diagnosed with Hodgkin lymphoma before age 17 years between 1955 and 1986. Over a median length of follow-up of 26.6 years, 162 individuals developed solid cancers. The researchers determined that the survivors had a 14-fold increased risk of developing cancer compared with the general population. They also noted that the cumulative incidence of any solid cancer was 26.4 percent at 40 years after a Hodgkin lymphoma diagnosis.

Risk factors for breast cancer among females were Hodgkin lymphoma diagnosis between 10 and 16 years of age and chest radiation. Males treated with chest radiation before 10 years of age were at highest risk for lung cancer. Hodgkin lymphoma survivors treated with abdominal/pelvic radiation and high-dose alkylating agents were at highest risk for colorectal cancer, and females exposed to neck radiation before 10 years of age were at highest risk for thyroid cancer. By age 50 years, the cumulative incidence of breast, lung, colorectal, and thyroid cancer was 45.3 percent, 4.2 percent, 9.5 percent, and 17.3 percent, respectively, among those at highest risk.

"This large multi-institutional, international cohort of childhood Hodgkin lymphoma allowed us to determine the risk of new solid cancers such as breast cancer, colorectal, cancer and thyroid cancer," said Dr. Bhatia. "More importantly, we were able to use host and clinical characteristics to identify subgroups of Hodgkin lymphoma survivors who were particularly vulnerable to developing these new cancers." She noted that these findings could be useful for developing screening strategies for individual survivors.

"As a physician and a childhood Hodgkin lymphoma survivor who developed radiation-related breast cancer 34 years after treatment, I cannot emphasize enough the importance of these data for the long-term care of survivors, as they not only underscore the necessity of lifelong cancer screening in that population, but also provide a stratification of risk for specific malignancies within subgroups, allowing for a more targeted approach to screening," said Allison Thompson-Graves, MD, who was not involved with the study.
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Full Citation:

"Risk of Solid Subsequent Malignant Neoplasms after Childhood Hodgkin Lymphoma - Identification of High Risk Populations to Guide Surveillance: A Report from the Late Effects Study Group." AS Holmqvist, Y Chen, J Berano Teh, C-L Sun, JM Birch, C van den Bos, L Diller, K Dilley, J Ginsberg, LT Martin, R Nagarajan, PC Nathan, JP Neglia, M Terenziani, D Tishler, AT Meadows, LL Robison, O Oberlin, and S Bhatia. CANCER; Published Online: December 17, 2018 (DOI: 10.1002/cncr.31807).

URL Upon Publication:http://doi.wiley.com/10.1002/cncr.31807

Author Contact: Tyler Greer, UAB's Director of External Public Relations, at tgreer@uab.edu or +1 205-934-2041.

About the Journal

CANCER is a peer-reviewed publication of the American Cancer Society integrating scientific information from worldwide sources for all oncologic specialties. The objective of CANCER is to provide an interdisciplinary forum for the exchange of information among oncologic disciplines concerned with the etiology, course, and treatment of human cancer. CANCER is published on behalf of the American Cancer Society by Wiley and can be accessed online at http://wileyonlinelibrary.com/journal/cancer.

Follow us on Twitter @JournalCancer

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Wiley is a global leader in research and education. Our online scientific, technical, medical, and scholarly journals, and our digital learning, assessment, certification and student-lifecycle services and solutions help universities, academic societies, businesses, governments and individuals to achieve their academic and professional goals. For more than 200 years, we have delivered consistent performance to our stakeholders. The Company's website can be accessed at http://www.wiley.com.

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