'Paper of the year' winner announced

December 18, 2003

Results of a search for the most important biomedical research papers of the past year are announced in this week's issue of THE LANCET. The Lancet's 24-member International Advisory Board put forward the nominations-which could be from any source, not just THE LANCET. The winning paper, chosen by the journal's editors, is:

Noah A Rosenberg (Program in Molecular and Computational Biology, University of Southern California) and colleagues' article Genetic structure of human populations, published in Science on Dec 20, 2002.

The nominator of this paper commented: "The paper by Rosenberg et al has two messages of utmost importance: one general biological, even humanistic, and one methodological. The general biological lesson is that the overwhelming source of human genetic variation is between individuals and not between ethnic groups. In the paper this becomes even clearer by the finding that there are no absolute genetic differences between ethnic groups: the differences that exist are in relative frequencies only. The methodological lesson is that for genetic risk assessment it follows that investigators can use standard epidemiological study designs, provided self-reported ethnic background is taken into account: for such risk assessment one should not worry about 'genetic admixture'. The most enlightening aspect of the paper, however, is the insight that it gives in the 'Genetic structure of human populations'-the very title of the paper."

Noah A Rosenberg said: "In working on this project, we were very fortunate to have had access to an excellent collection of genetic samples from around the world. Our work is only an initial step towards understanding the relationship between population ancestry and genetic disease. We hope that future collaborations can link anthropology and genetics to make advances in medicine." (quote by e-mail; does not appear in published paper).

Other nominated papers included the identification of the SARS coronavirus (Lancet), a vaccine trial of the human papilloma virus (New England Journal of Medicine), and the Million Women Study highlighting the increased risk of breast cancer from combination hormone replacement therapy (Lancet).

Lancet Editor Richard Horton comments: "No existing prize in science or medicine recognises the vital importance of multi-disciplinary collaboration - this is a fatal flaw in, for example, the Nobel awards. With this prize, we aim to salute truly first-class advances in thinking or practice which would otherwise go unnoticed by the contemporary establishment of science".
Contact: Lancet Press Office, 32 Jamestown Road, London NW1 7BY, UK;
T) 44-207-424-4949/4249;
E) pressoffice@lancet.com

For a copy of Dr Rosenberg's winning paper please contact: Christina Smith, Communications Officer, Science magazine, Office of Public Programs, American Association for the Advancement of Science, 1200 New York Avenue, NW, Washington, DC 20005, USA;
T) 202-326-7088;
E) ccsmith@aaas.org

Dr Noah A Rosenberg, c/o University of Southern California News Service;
T) 213-740-2215;
F) 213-740-7600;
E) uscnews@usc.edu


Related Medicine Articles from Brightsurf:

An ultrasonic projector for medicine
A chip-based technology that modulates intensive sound pressure profiles with high resolution opens up new possibilities for ultrasound therapy.

A new discovery in regenerative medicine
An international collaboration involving Monash University and Duke-NUS researchers have made an unexpected world-first stem cell discovery that may lead to new treatments for placenta complications during pregnancy.

How dinosaur research can help medicine
The intervertebral discs connect the vertebrae and give the spine its mobility.

Graduates of family medicine residencies are likely to enter and remain in family medicine
This study provides an overview of the characteristics of physicians who completed family medicine residency training from 1994 to 2017.

Nuclear medicine and COVID-19: New content from The Journal of Nuclear Medicine
In one of five new COVID-19-related articles and commentaries published in the June issue of The Journal of Nuclear Medicine, Johnese Spisso discusses how the UCLA Hospital System has dealt with the pandemic.

Moving beyond 'defensive medicine'
Study shows removing liability concerns slightly increases C-section procedures during childbirth.

NUS Medicine researchers can reprogramme cells to original state for regenerative medicine
Scientists from NUS Medicine have found a way to induce totipotency in embryonic cells that have already matured into pluripotency.

Protein injections in medicine
One day, medical compounds could be introduced into cells with the help of bacterial toxins.

Study reveals complementary medicine use remains hidden to conventional medicine providers
Research reveals that 1 in 3 complementary medicine (CM) users do not disclose their CM use to their medical providers, posing significant direct and indirect risks of adverse effects and harm due to unsafe concurrent use of CM and conventional medicine use.

Study of traditional medicine finds high use in Sub-Saharan Africa despite modern medicine
Researchers who have undertaken the first systematic review of into the use of traditional, complementary and alternative medicines (TCAM) in Sub-Saharan Africa found its use is significant and not just because of a lack of resources or access to 'conventional medicine'.

Read More: Medicine News and Medicine Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.