NJIT computer scientist audits government, hospital terms seeking errors

December 19, 2006

Some men seek rare antiques, others hunt wild boar. New Jersey Institute of Technology (NJIT) computer scientist Yehoshua Perl, PhD, creates elegant logical structures to track down errant or misplaced medical terms. The errors creep into documents and databases developed by corporations, government agencies, hospitals and academic institutions that design, maintain and use terminologies throughout a variety of systems.

"People are human and, unfortunately, errors creep into these terminologies," said Perl. "It is our job as research auditors to devise techniques to help editors and terminology curators to find these errors. I like to say that an auditor 'smells' out where there might be a problem. We develop techniques to 'smell' the errors."

Perl's research is funded by a three-year $1.43-million grant from the National Library of Medicine (NLM), a branch of the National Institutes of Health.

Why bother cleaning up ambiguous and redundant categories in medical terminologies? "Many errors may never cause a problem," said Perl. "However, some will. Take penicillin. Drug manufacturers refer to it with different names. If all these titles are not fed correctly into the pharmacy information system, the computers won't consistently flag the drug as penicillin. Even worse, a doctor then might prescribe the drug, the computer won't indicate that it's a penicillin derivative and inadvertently the physician has given drug to someone allergic to it."

The NLM is responsible for auditing the Unified Medical Language System (UMLS), a terminological knowledge base of 1.3 million concepts taken from 100 specialized medical terminologies and coding systems. The NLM has been responsible for the veracity of UMLS terminology since1986.

"The NLM needs this work done because there has been much confusion in clinical information systems," said Perl. "Each professional insists on expressing something his way. Physicians, surgeons and even laboratory technicians use different terms for the same concept. When people communicate with each other, they are capable of inferring meanings from contexts. But using computers to understand or communicate clinical and pharmacological information needs well-defined terms."

Perl's obsession with errors began with a grant in 1995 from the National Institute of Standards and Technology for the Object Oriented Healthcare Vocabulary Repository. Perl developed tools for managing clinical terms used in hospitals. Perl studied the Medical Entities Dictionary which contained 46,000 terms and 500,000 relationships between them. The researchers developed a compact schema organizing the terms into 90 classes. This schema exposed errors in the dictionary which were then corrected.

Today Perl and his auditing team don't examine just one dictionary or coding system, but create methodologies to root out problems in all of them. Their methodology is a game of logic. Seated at computers, the auditors search through a given system and reorganize material, partitioning it into smaller groups of similar concepts. The files are then re-edited and brought down in size into smaller and more elegantly organized and easier-to-understand files. This organization differs from the organization used in the design stage. The latter system also permits a fresh view.

Perl's auditors then scrutinize the smaller files of similar concepts in an outline spread across a computer screen. Their task is to look for errors which are more likely to be noticed, because common sense dictates that errant or missing items are easier to notice in broader-based groupings. The Journal of the American Medical Informatics Association outlined the team's research methodology this month in "Auditing as Part of the Terminology Design Life Cycle" (November/December 2006). Using colorful charts, the article explained how and why data should be organized and then used the same data to illustrate examples of the auditing process.

As a test case, researchers scrutinized the National Cancer Institute Thesaurus (a source terminology of UMLS). Concepts immediately emerged needing re-classification. For example, inhaling was listed as part of respiration. But the concept should have appeared under lung. Missing altogether was the inverse concept of exhaling.
Perl has authored more than120 papers in international journals and conferences. His research interests are medical terminologies, object-oriented databases and knowledge representation, design and analysis of algorithms, sorting networks, graph theory, and data compression. He received his PhD in computer science from the Weizmann Institute of Science, Israel. In 1996, NJIT awarded him the highest research honor, the Harlan Perlis Research Award.

NJIT researchers working with Perl include James Geller, PhD, professor; Barry Cohen, PhD, assistant professor; NJIT former doctoral students Michael Halper, PhD, of Kean University and Haunying Gu, PhD, of University of Medicine and Dentistry of New Jersey. Both researchers were former students of Perl and Geller

NJIT, New Jersey's science and technology university, at the edge in knowledge, enrolls more than 8,000 students in bachelor's, master's and doctoral degrees in 92 degree programs offered by six colleges: Newark College of Engineering, New Jersey School of Architecture, College of Science and Liberal Arts, School of Management, Albert Dorman Honors College and College of Computing Sciences. NJIT is renowned for expertise in architecture, applied mathematics, wireless communications and networking, solar physics, advanced engineered particulate materials, nanotechnology, neural engineering and e-learning. In 2006, Princeton Review named NJIT among the nation's top 25 campuses for technology and top 150 for best value. U.S. News & World Report's 2007 Annual Guide to America's Best Colleges ranked NJIT in the top tier of national research universities.

New Jersey Institute of Technology
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