Exploring future preventive strategies for patients at imminent risk of hip fracture

December 19, 2016

Hip fractures are of great concern as they are the most severe type of fracture in osteoporotic patients, associated with premature death, and commonly leading to long-term physical disability, impaired capacity to perform daily activities and live independently, and reduced quality of life. In the Western world, the lifetime risk for hip fracture in women over the age of 50 years is 18-23% and by 2050, the worldwide annual number of hip fractures is expected to reach 4.5 to 6.3 million, reflecting the continuous ageing of the population.

Prevention of hip fracture is currently based on pharmacological intervention together with regular physical activity, prevention of falls, and correction of nutritional deficiencies, including vitamin D repletion. However, the efficacy of the various measures to reduce hip fractures is at most 50% and may need months or years before becoming effective. Additional challenges include the high treatment gap (even among those who have already suffered a hip fracture) and that 50% or more of patients who are on pharmacological treatment discontinue it within a year. Clearly there are unmet needs for patients at imminent risk of hip fractures that need to be addressed, including exploring potential new approaches.

A new review authored by a European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO)/International Osteoporosis Foundation (IOF) working group has looked at the presently available approaches for prevention of hip fracture and at potential future approaches to address unmet needs in very high-risk patients.

The panel discussions concluded: Professor René Rizzoli, lead author and Chair of the ESCEO Scientific Advisory Board said: "Given the very serious, indeed life-threatening, repercussions of hip fractures, we must do all we can to find effective strategies for prevention, including in the frail elderly. Notwithstanding the many challenges involved, the presently untapped potential of preventive surgical interventions for patients at imminent risk of hip fracture deserves further investigation by researchers in the field."
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Reference:

Ferrari, S., Reginster, JY., Brandi, M.L. et al. Unmet needs and current and future approaches for osteoporotic patients at high risk of hip fracture. Arch Osteoporos (2016) 11: 37. doi:10.1007/s11657-016-0292-1 https://link.springer.com/article/10.1007/s11657-016-0292-1

Archives of Osteoporosis:

Archives of Osteoporosis is an international multidisciplinary journal which is a joint initiative of the International Osteoporosis Foundation and the National Osteoporosis Foundation of the USA. The journal highlights the specificities of different regions around the world concerning epidemiology, reference values for bone density and bone metabolism, as well as clinical aspects of osteoporosis and other bone diseases. https://link.springer.com/journal/11657

Note: IOF members receive free access to this journal via the IOF website. https://www.iofbonehealth.org/become-member

About IOF:

The International Osteoporosis Foundation (IOF) is the world's largest nongovernmental organization dedicated to the prevention, diagnosis and treatment of osteoporosis and related musculoskeletal diseases. IOF members, including committees of scientific researchers as well as 234 patient, medical and research societies in 99 locations, work together to make fracture prevention and healthy mobility a worldwide heath care priority. http://www.iofbonehealth.org / http://www.facebook.com/iofbonehealth@iofbonehealth

International Osteoporosis Foundation

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