Boston University researcher awarded 2 NIH grants

December 20, 2011

(Boston) - Patricia F. Coogan, ScD, an associate professor of epidemiology at Boston University's Slone Epidemiology Center (SEC), recently was awarded funding for two grants from the National Institutes of Health. The first is a five-year grant from the National Institute of Environmental Health Sciences that will study air pollution and risk of incident hypertension and diabetes in African American women. The second award is for a three-year study on the psychosocial factors and the risk of incident asthma in African American women, funded by the National Heart, Lung and Blood Institute.

Using data from the SEC's Black Women's Health Study (BWHS), Coogan and her colleagues will estimate long-term participant exposure to traffic-related pollutions as indicated by PM2.5 and the nitrogen oxides (markers of traffic-related pollution). The study will be the first investigation of the effect of air pollution on incidence of hypertension, the first large-scale investigation of its effect on diabetes incidence, and the first study of air pollution effects specifically in African American women.

According to Coogan the hypotheses are of critical public health importance given the high and growing prevalence of hypertension and diabetes in the U.S., the disparity between incidence rates among African American and white women, and the ubiquity of exposure to air pollution. "Positive findings will inform public policy on air quality regulation, provide insight into a novel pathway whereby air pollution causes cardiovascular events, and illuminate causes of racial disparities in hypertension and diabetes incidence," said Coogan.

In the second study, Coogan again will use data from the BWHS to prospectively estimate the influence of experiences of racism, violence during childhood and adolescence, depressive symptoms and neighborhood characteristics including socioeconomic status and racial segregation, on asthma incidence. This is the first prospective study to consider the effects of these psychosocial exposures on the incidence of adult asthma in African American women.

"Psychosocial factors may be of particular importance in asthma incidence in black women because the prevalence of experiences of violence, racism, depression, and living in disadvantaged neighborhoods are higher than in white women. If such experiences increase the risk of adult onset asthma, they may contribute to the racial disparity in asthma morbidity," explained Coogan. She believes positive results may direct intervention efforts to address stressors and may motivate further mechanistic studies of how chronic stress leads to asthma.
-end-
The BWHS is the largest follow-up study of African-American women yet undertaken; 59,000 black women, ages 21-69, from all areas of the U.S. who enrolled in the study in 1995 have been followed since then. In addition to diabetes, hypertension and asthma, other conditions of particular interest are lupus erythematosus, uterine fibroids, sarcoidosis and preterm birth.

Boston University Medical Center

Related Diabetes Articles from Brightsurf:

New diabetes medication reduced heart event risk in those with diabetes and kidney disease
Sotagliflozin - a type of medication known as an SGLT2 inhibitor primarily prescribed for Type 2 diabetes - reduces the risk of adverse cardiovascular events for patients with diabetes and kidney disease.

Diabetes drug boosts survival in patients with type 2 diabetes and COVID-19 pneumonia
Sitagliptin, a drug to lower blood sugar in type 2 diabetes, also improves survival in diabetic patients hospitalized with COVID-19, suggests a multicenter observational study in Italy.

Making sense of diabetes
Throughout her 38-year nursing career, Laurel Despins has progressed from a bedside nurse to a clinical nurse specialist and has worked in medical, surgical and cardiac intensive care units.

Helping teens with type 1 diabetes improve diabetes control with MyDiaText
Adolescence is a difficult period of development, made more complex for those with Type 1 diabetes mellitus (T1DM).

Diabetes-in-a-dish model uncovers new insights into the cause of type 2 diabetes
Researchers have developed a novel 'disease-in-a-dish' model to study the basic molecular factors that lead to the development of type 2 diabetes, uncovering the potential existence of major signaling defects both inside and outside of the classical insulin signaling cascade, and providing new perspectives on the mechanisms behind insulin resistance in type 2 diabetes and possibly opportunities for the development of novel therapeutics for the disease.

Tele-diabetes to manage new-onset diabetes during COVID-19 pandemic
Two new case studies highlight the use of tele-diabetes to manage new-onset type 1 diabetes in an adult and an infant during the COVID-19 pandemic.

Genetic profile may predict type 2 diabetes risk among women with gestational diabetes
Women who go on to develop type 2 diabetes after having gestational, or pregnancy-related, diabetes are more likely to have particular genetic profiles, suggests an analysis by researchers at the National Institutes of Health and other institutions.

Maternal gestational diabetes linked to diabetes in children
Children and youth of mothers who had gestational diabetes during pregnancy are at increased risk of diabetes themselves, according to new research published in CMAJ (Canadian Medical Association Journal).

Two diabetes medications don't slow progression of type 2 diabetes in youth
In youth with impaired glucose tolerance or recent-onset type 2 diabetes, neither initial treatment with long-acting insulin followed by the drug metformin, nor metformin alone preserved the body's ability to make insulin, according to results published online June 25 in Diabetes Care.

People with diabetes visit the dentist less frequently despite link between diabetes, oral health
Adults with diabetes are less likely to visit the dentist than people with prediabetes or without diabetes, finds a new study led by researchers at NYU Rory Meyers College of Nursing and East Carolina University's Brody School of Medicine.

Read More: Diabetes News and Diabetes Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.