Longevity protein SIRT6 also protects against fatty liver and fatty liver disease

December 20, 2019

Fatty liver, or hepatic steatosis, which develops when the body produces too much fat or doesn't metabolize fat efficiently enough, affects around 25% of the global population. Excess fat is stored in liver cells, where it accumulates and can cause fatty liver and other diseases.

In a study just published in the journal Cell Reports, researchers reveal for the first time that SIRT6, a protein involved in regulating many biological processes such as aging, obesity, insulin resistance, inflammation and metabolism, also plays a crucial role in burning and regulating liver fat metabolism.

SIRT6 regulates fat metabolism by activating another protein called peroxisome proliferator-activated receptor alpha (PPAR-alpha). This protein promotes the burning of fat in the liver. "SIRT6 is like a juggler that balances and coordinates between metabolic processes in the body," says the study's lead author Prof. Haim Cohen, of Bar-Ilan University's Mina and Everard Goodman Faculty of Life Sciences. "By working together with PPAR-alpha, SIRT6 can actually send a message to the body to burn more fat. This cooperation is one way in which SIRT6 protects against fatty liver and fatty liver disease, as well as obesity-related damage."

Previous research by Cohen and colleagues revealed that increased SIRT6 extends lifespan. To test how the protein might also extend healthy lifespan the researchers in this study increased regular SIRT6 levels to counteract the decrease in SIRT6 found in a high fat diet and fatty liver disease. Using a computational tool developed with Prof. Ziv Bar Joseph from Carnegie Mellon University, they looked at different metabolic states, such as fasting and regular diet, and found that a greater expression of SIRT6 leads to the burning of more fat, specifically in the liver.

"Not only does SIRT6 work with PPAR-alpha to prime the body to burn more fat and coordinate fat metabolism in the liver, but it can also regulate other metabolic pathways related to fat in the liver such as cholesterol and triglycerides metabolism," says Shoshana Naiman, a doctoral student at Bar-Ilan University's Mina and Everard Goodman Faculty of Life Sciences, who co-authored the study.
-end-
The team will now attempt to identify therapeutic approaches that can target and activate SIRT6.

This research was supported by grants from the Israel Science Foundation, the U.S.-Israel Binational Science Foundation, and the Sagol Healthy Longevity Center at Bar-Ilan University.

Bar-Ilan University

Related Aging Articles from Brightsurf:

Aging-US: 'From Causes of Aging to Death from COVID-19' by Mikhail V. Blagosklonny
Aging-US recently published ''From Causes of Aging to Death from COVID-19'' by Blagosklonny et al. which reported that COVID-19 is not deadly early in life, but mortality increases exponentially with age - which is the strongest predictor of mortality.

Understanding the effect of aging on the genome
EPFL scientists have measured the molecular footprint that aging leaves on various mouse and human tissues.

Muscle aging: Stronger for longer
With life expectancy increasing, age-related diseases are also on the rise, including sarcopenia, the loss of muscle mass due to aging.

Aging memories may not be 'worse, 'just 'different'
A study from the Department of Psychological & Brain Sciences in Arts & Sciences adds nuance to the idea that an aging memory is a poor one and finds a potential correlation between the way people process the boundaries of events and episodic memory.

A new biomarker for the aging brain
Researchers at the RIKEN Center for Biosystems Dynamics Research (BDR) in Japan have identified changes in the aging brain related to blood circulation.

Scientists invented an aging vaccine
A new way to prevent autoimmune diseases associated with aging like atherosclerosis, Alzheimer's disease, and Parkinson's disease was described in the article.

The first roadmap for ovarian aging
Infertility likely stems from age-related decline of the ovaries, but the molecular mechanisms that lead to this decline have been unclear.

Researchers discover new cause of cell aging
New research from the USC Viterbi School of Engineering could be key to our understanding of how the aging process works.

Deep Aging Clocks: The emergence of AI-based biomarkers of aging and longevity
The advent of deep biomarkers of aging, longevity and mortality presents a range of non-obvious applications.

Intelligence can link to health and aging
For over 100 years, scientists have sought to understand what links a person's general intelligence, health and aging.

Read More: Aging News and Aging Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.